Aliases for GFRA3 Gene
External Ids for GFRA3 Gene
Previous GeneCards Identifiers for GFRA3 Gene
The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]
GeneCards Summary for GFRA3 Gene
GFRA3 (GDNF Family Receptor Alpha 3) is a Protein Coding gene. Diseases associated with GFRA3 include Postsurgical Hypothyroidism. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and axon guidance receptor activity. An important paralog of this gene is GFRA1.
UniProtKB/Swiss-Prot Summary for GFRA3 Gene
Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.