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Aliases for GFOD2 Gene

Aliases for GFOD2 Gene

  • Glucose-Fructose Oxidoreductase Domain Containing 2 2 3 5
  • EC 1.-.-.- 4

External Ids for GFOD2 Gene

Previous GeneCards Identifiers for GFOD2 Gene

  • GC16M066266
  • GC16M053581

Summaries for GFOD2 Gene

GeneCards Summary for GFOD2 Gene

GFOD2 (Glucose-Fructose Oxidoreductase Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is GFOD1.

UniProtKB/Swiss-Prot for GFOD2 Gene

  • Promotes matrix assembly.

Additional gene information for GFOD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GFOD2 Gene

Genomics for GFOD2 Gene

GeneHancer (GH) Regulatory Elements for GFOD2 Gene

Promoters and enhancers for GFOD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I067718 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 555.5 +0.0 35 2.7 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 GFOD2 RANBP10 TSNAXIP1 ACD PARD6A TMEM208 EDC4 DUS2 PIR36768
GH16I067714 Promoter 0.6 EPDnew 550.4 +5.2 5178 0.1 CEBPB GFOD2 C16orf86 ENKD1 ACD PARD6A THAP11 EDC4 CENPT CARMIL2 RIPOR1
GH16I067672 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.5 +45.7 45691 2.9 NFIB ARID4B MZF1 ZNF2 IRF4 RAD21 ZBTB40 YY1 ARID2 ZNF143 PIR62194 PRMT7 GFOD2 HSD11B2 PIR36768
GH16I067772 Enhancer 1 Ensembl ENCODE 11.8 -54.3 -54310 1.6 FOXA2 RAD21 YY1 TCF12 ZNF766 SCRT2 RXRA ZEB2 REST NR2F2 DUS2 GFOD2 TSNAXIP1 RANBP10 THAP11 CENPT PARD6A ACD EDC4 CARMIL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GFOD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GFOD2 gene promoter:

Genomic Locations for GFOD2 Gene

Genomic Locations for GFOD2 Gene
44,891 bases
Minus strand

Genomic View for GFOD2 Gene

Genes around GFOD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GFOD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GFOD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GFOD2 Gene

Proteins for GFOD2 Gene

  • Protein details for GFOD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glucose-fructose oxidoreductase domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q69YL9
    • Q6UXX6
    • Q7L648
    • Q8TE86
    • Q9BQ07
    • R4GNG5

    Protein attributes for GFOD2 Gene

    385 amino acids
    Molecular mass:
    42255 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ88536.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GFOD2 Gene


neXtProt entry for GFOD2 Gene

Post-translational modifications for GFOD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GFOD2 Gene

Domains & Families for GFOD2 Gene

Gene Families for GFOD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for GFOD2 Gene

Suggested Antigen Peptide Sequences for GFOD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Gfo/Idh/MocA family.
  • Belongs to the Gfo/Idh/MocA family.
genes like me logo Genes that share domains with GFOD2: view

Function for GFOD2 Gene

Molecular function for GFOD2 Gene

UniProtKB/Swiss-Prot Function:
Promotes matrix assembly.

Enzyme Numbers (IUBMB) for GFOD2 Gene

Phenotypes From GWAS Catalog for GFOD2 Gene

Gene Ontology (GO) - Molecular Function for GFOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GFOD2: view
genes like me logo Genes that share phenotypes with GFOD2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GFOD2

miRNA for GFOD2 Gene

miRTarBase miRNAs that target GFOD2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GFOD2 Gene

Localization for GFOD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GFOD2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GFOD2 gene
Compartment Confidence
extracellular 3
nucleus 3
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GFOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
genes like me logo Genes that share ontologies with GFOD2: view

Pathways & Interactions for GFOD2 Gene

SuperPathways for GFOD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GFOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with GFOD2: view

No data available for Pathways by source and SIGNOR curated interactions for GFOD2 Gene

Drugs & Compounds for GFOD2 Gene

No Compound Related Data Available

Transcripts for GFOD2 Gene

Unigene Clusters for GFOD2 Gene

Glucose-fructose oxidoreductase domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GFOD2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3: - - - -
SP5: -

Relevant External Links for GFOD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GFOD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GFOD2 Gene

Protein differential expression in normal tissues from HIPED for GFOD2 Gene

This gene is overexpressed in Placenta (33.8), Plasma (26.1), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GFOD2 Gene

Protein tissue co-expression partners for GFOD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GFOD2 Gene:


SOURCE GeneReport for Unigene cluster for GFOD2 Gene:


Evidence on tissue expression from TISSUES for GFOD2 Gene

  • Lung(4.2)
  • Skin(4.2)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with GFOD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GFOD2 Gene

Orthologs for GFOD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GFOD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GFOD2 33 34
  • 99.13 (n)
(Bos Taurus)
Mammalia GFOD2 33 34
  • 91 (n)
(Canis familiaris)
Mammalia GFOD2 33 34
  • 90.22 (n)
(Rattus norvegicus)
Mammalia Gfod2 33
  • 87.53 (n)
(Mus musculus)
Mammalia Gfod2 33 16 34
  • 87.45 (n)
(Monodelphis domestica)
Mammalia GFOD2 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia GFOD2 34
  • 85 (a)
(Gallus gallus)
Aves GFOD2 33 34
  • 78.21 (n)
(Anolis carolinensis)
Reptilia GFOD2 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gfod2 33
  • 68.67 (n)
Str.15899 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53910 33
(Danio rerio)
Actinopterygii gfod2 33 34
  • 63.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17712 34
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.291 34
  • 37 (a)
Species where no ortholog for GFOD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GFOD2 Gene

Gene Tree for GFOD2 (if available)
Gene Tree for GFOD2 (if available)

Paralogs for GFOD2 Gene

Paralogs for GFOD2 Gene

(1) SIMAP similar genes for GFOD2 Gene using alignment to 2 proteins: Pseudogenes for GFOD2 Gene

genes like me logo Genes that share paralogs with GFOD2: view

Variants for GFOD2 Gene

Sequence variations from dbSNP and Humsavar for GFOD2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000038653 -- 67,676,963(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000084362 -- 67,686,406(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000172703 -- 67,683,007(-) C/A 3_prime_UTR_variant, intron_variant
rs1000259123 -- 67,693,455(-) A/G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000324324 -- 67,706,235(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GFOD2 Gene

Variant ID Type Subtype PubMed ID
nsv1842 CNV insertion 18451855
nsv475320 CNV novel sequence insertion 20440878
nsv479975 CNV novel sequence insertion 20440878
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv952046 CNV deletion 24416366

Variation tolerance for GFOD2 Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GFOD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GFOD2 Gene

Disorders for GFOD2 Gene

Additional Disease Information for GFOD2

No disorders were found for GFOD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GFOD2 Gene

Publications for GFOD2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PMID: 20864672) Waterworth DM … Sandhu MS (Arteriosclerosis, thrombosis, and vascular biology 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for GFOD2 Gene

Sources for GFOD2 Gene

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