Aliases for GFOD1 Gene

Aliases for GFOD1 Gene

  • Glucose-Fructose Oxidoreductase Domain Containing 1 2 3 5
  • Glucose-Fructose Oxidoreductase Domain-Containing Protein 1 3 4
  • C6orf114 3 4
  • Chromosome 6 Open Reading Frame 114 2
  • EC 1.-.-.- 4
  • ADG-90 3

External Ids for GFOD1 Gene

Previous HGNC Symbols for GFOD1 Gene

  • C6orf114

Previous GeneCards Identifiers for GFOD1 Gene

  • GC06M013426
  • GC06M013471

Summaries for GFOD1 Gene

GeneCards Summary for GFOD1 Gene

GFOD1 (Glucose-Fructose Oxidoreductase Domain Containing 1) is a Protein Coding gene. Diseases associated with GFOD1 include Attention Deficit-Hyperactivity Disorder. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is GFOD2.

Additional gene information for GFOD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GFOD1 Gene

Genomics for GFOD1 Gene

GeneHancer (GH) Regulatory Elements for GFOD1 Gene

Promoters and enhancers for GFOD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J013483 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 511.6 +1.5 1524 5.3 SIN3A NRF1 POLR2G USF1 NCOR1 ZFX ZNF10 EP300 ZIC2 POLR2A GFOD1 GFOD1-AS1 lnc-SIRT5-6 SIRT5 RF00017-5278
GH06J013489 Promoter/Enhancer 0.7 Ensembl dbSUPER 500.7 -1.4 -1438 0.2 RXRA HNF4A SP1 GFOD1 lnc-SIRT5-6 piR-57133-507
GH06J013473 Promoter/Enhancer 0.7 EPDnew dbSUPER 500.4 +15.6 15579 0.1 ZNF143 ZNF766 lnc-TBC1D7-8 GFOD1 SIRT5 RF00017-5278
GH06J013394 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 30 +91.7 91661 6.8 ZSCAN5C GTF2E2 PHB2 ZNF10 ZBTB5 ZIC2 ZBTB11 HES1 MYC CTBP1 lnc-PHACTR1-2 lnc-PHACTR1-3 GFOD1 GFOD1-AS1 SIRT5 NOL7 TBC1D7 piR-38352-459
GH06J013424 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 28.7 +57.1 57079 11.2 CTCF SIN3A SP1 EP300 RELA RCOR1 RAD21 TRIM22 POLR2A RBM25 GFOD1 TBC1D7 GFOD1-AS1 SIRT5 RANBP9 lnc-SIRT5-3 piR-33804-040
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GFOD1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GFOD1

Top Transcription factor binding sites by QIAGEN in the GFOD1 gene promoter:
  • AP-4
  • HNF-3beta
  • HOXA9
  • HOXA9B
  • Ik-2
  • Meis-1
  • Meis-1b
  • NRSF form 1
  • NRSF form 2
  • Pax-5

Genomic Locations for GFOD1 Gene

Genomic Locations for GFOD1 Gene
129,833 bases
Minus strand
129,833 bases
Minus strand

Genomic View for GFOD1 Gene

Genes around GFOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GFOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GFOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GFOD1 Gene

Proteins for GFOD1 Gene

  • Protein details for GFOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glucose-fructose oxidoreductase domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A8E4L6
    • Q5T058
    • Q96JD4
    • Q9H5K2

    Protein attributes for GFOD1 Gene

    390 amino acids
    Molecular mass:
    43158 Da
    Quaternary structure:
    No Data Available
    • [Isoform 3]: Dubious isoform.

    Alternative splice isoforms for GFOD1 Gene


neXtProt entry for GFOD1 Gene

Post-translational modifications for GFOD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GFOD1 Gene

No data available for DME Specific Peptides for GFOD1 Gene

Domains & Families for GFOD1 Gene

Gene Families for GFOD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for GFOD1 Gene

  • Oxidoreductase, N-terminal

Suggested Antigen Peptide Sequences for GFOD1 Gene

GenScript: Design optimal peptide antigens:
  • Glucose-fructose oxidoreductase domain-containing protein 1 (GFOD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Gfo/Idh/MocA family.
  • Belongs to the Gfo/Idh/MocA family.
genes like me logo Genes that share domains with GFOD1: view

Function for GFOD1 Gene

Enzyme Numbers (IUBMB) for GFOD1 Gene

Phenotypes From GWAS Catalog for GFOD1 Gene

Gene Ontology (GO) - Molecular Function for GFOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GFOD1: view
genes like me logo Genes that share phenotypes with GFOD1: view

Animal Models for GFOD1 Gene

MGI Knock Outs for GFOD1:
  • Gfod1 Gfod1<tm1b(KOMP)Mbp>

Animal Model Products

  • Taconic Biosciences Mouse Models for GFOD1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GFOD1

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GFOD1 Gene

Localization for GFOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GFOD1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GFOD1 gene
Compartment Confidence
extracellular 3
nucleus 3
cytosol 3
plasma membrane 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GFOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GFOD1: view

Pathways & Interactions for GFOD1 Gene

PathCards logo

SuperPathways for GFOD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GFOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with GFOD1: view

No data available for Pathways by source and SIGNOR curated interactions for GFOD1 Gene

Drugs & Compounds for GFOD1 Gene

No Compound Related Data Available

Transcripts for GFOD1 Gene

mRNA/cDNA for GFOD1 Gene

18 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GFOD1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GFOD1 Gene

No ASD Table

Relevant External Links for GFOD1 Gene

GeneLoc Exon Structure for

Expression for GFOD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GFOD1 Gene

Protein differential expression in normal tissues from HIPED for GFOD1 Gene

This gene is overexpressed in Fetal gut (33.3), Placenta (6.9), and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GFOD1 Gene

Protein tissue co-expression partners for GFOD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GFOD1

SOURCE GeneReport for Unigene cluster for GFOD1 Gene:


Evidence on tissue expression from TISSUES for GFOD1 Gene

  • Nervous system(4.6)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with GFOD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GFOD1 Gene

Orthologs for GFOD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GFOD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GFOD1 31 30
  • 99.54 (n)
(Monodelphis domestica)
Mammalia GFOD1 31
  • 96 (a)
(Canis familiaris)
Mammalia GFOD1 31
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia GFOD1 31
  • 94 (a)
(Rattus norvegicus)
Mammalia Gfod1 30
  • 90.77 (n)
(Mus musculus)
Mammalia Gfod1 17 31 30
  • 90.68 (n)
(Bos Taurus)
Mammalia GFOD1 30
  • 86.15 (n)
(Gallus gallus)
Aves GFOD1 31 30
  • 82.74 (n)
(Anolis carolinensis)
Reptilia GFOD1 31
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gfod1 30
  • 75.81 (n)
(Danio rerio)
Actinopterygii GFOD1 31
  • 85 (a)
si:ch211-276f18.2 30
  • 75.3 (n)
Dr.12253 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008097 30
  • 58.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17712 31 30
  • 56.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.291 31
  • 41 (a)
Cin.14263 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14263 30
Species where no ortholog for GFOD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GFOD1 Gene

Gene Tree for GFOD1 (if available)
Gene Tree for GFOD1 (if available)
Evolutionary constrained regions (ECRs) for GFOD1: view image

Paralogs for GFOD1 Gene

Paralogs for GFOD1 Gene

(1) SIMAP similar genes for GFOD1 Gene using alignment to 2 proteins:

  • S4R302_HUMAN
genes like me logo Genes that share paralogs with GFOD1: view

Variants for GFOD1 Gene

Additional dbSNP identifiers (rs#s) for GFOD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GFOD1 Gene

Variant ID Type Subtype PubMed ID
esv1029682 CNV insertion 17803354
esv2731605 CNV deletion 23290073
esv3308926 CNV mobile element insertion 20981092
esv3354997 CNV duplication 20981092
esv3390454 CNV insertion 20981092
esv3608126 CNV loss 21293372
nsv1033620 CNV gain 25217958
nsv1074381 CNV deletion 25765185
nsv462640 CNV gain 19166990
nsv470802 CNV gain 18288195
nsv520921 CNV loss 19592680
nsv600994 CNV gain 21841781

Variation tolerance for GFOD1 Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GFOD1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GFOD1 Gene

Disorders for GFOD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GFOD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • adhd
- elite association - COSMIC cancer census association via MalaCards
Search GFOD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GFOD1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GFOD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GFOD1 Gene

Publications for GFOD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PMID: 18821565) Lasky-Su J … Faraone SV (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 54

Products for GFOD1 Gene

Sources for GFOD1 Gene