Aliases for GFM2 Gene
External Ids for GFM2 Gene
Previous GeneCards Identifiers for GFM2 Gene
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
GeneCards Summary for GFM2 Gene
GFM2 (G Elongation Factor Mitochondrial 2) is a Protein Coding gene. Diseases associated with GFM2 include Combined Oxidative Phosphorylation Deficiency 39 and Mitochondrial Disorders. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include GTP binding and translation elongation factor activity. An important paralog of this gene is GFM1.
UniProtKB/Swiss-Prot Summary for GFM2 Gene
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.