Aliases for GFM1 Gene
External Ids for GFM1 Gene
Previous GeneCards Identifiers for GFM1 Gene
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. [provided by RefSeq, Jul 2008]
GeneCards Summary for GFM1 Gene
GFM1 (G Elongation Factor Mitochondrial 1) is a Protein Coding gene. Diseases associated with GFM1 include Combined Oxidative Phosphorylation Deficiency 1 and Combined Oxidative Phosphorylation Deficiency. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is GFM2.
UniProtKB/Swiss-Prot Summary for GFM1 Gene
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.