Aliases for GFER Gene
External Ids for GFER Gene
Previous GeneCards Identifiers for GFER Gene
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GFER Gene
GFER (Growth Factor, Augmenter Of Liver Regeneration) is a Protein Coding gene. Diseases associated with GFER include Myopathy, Mitochondrial Progressive, With Congenital Cataract And Developmental Delay and Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay. Among its related pathways are Mitochondrial protein import and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include growth factor activity and protein disulfide oxidoreductase activity.
UniProtKB/Swiss-Prot Summary for GFER Gene
[Isoform 1]: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.
[Isoform 2]: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.