Aliases for GET4 Gene

Aliases for GET4 Gene

  • Guided Entry Of Tail-Anchored Proteins Factor 4 2 3 5
  • Transmembrane Domain Recognition Complex 35 KDa Subunit 3 4
  • Transmembrane Domain Recognition Complex, 35kDa 2 3
  • Golgi To ER Traffic Protein 4 Homolog 3 4
  • Golgi To ER Traffic Protein 4 2 3
  • Conserved Edge Protein 2 3
  • C7orf20 3 4
  • TRC35 3 4
  • CEE 3 4
  • Golgi To ER Traffic Protein 4 Homolog (S. Cerevisiae) 2
  • Chromosome 7 Open Reading Frame 20 2
  • Conserved Edge Expressed Protein 3
  • Conserved Edge-Expressed Protein 4
  • CGI-20 Protein 2
  • H_NH1244M04.5 3
  • CGI-20 3

External Ids for GET4 Gene

Previous HGNC Symbols for GET4 Gene

  • C7orf20

Previous GeneCards Identifiers for GET4 Gene

  • GC07P000916

Summaries for GET4 Gene

GeneCards Summary for GET4 Gene

GET4 (Guided Entry Of Tail-Anchored Proteins Factor 4) is a Protein Coding gene. Diseases associated with GET4 include Louping Ill and Postmenopausal Atrophic Vaginitis.

UniProtKB/Swiss-Prot Summary for GET4 Gene

  • As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).

Gene Wiki entry for GET4 Gene

Additional gene information for GET4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GET4 Gene

Genomics for GET4 Gene

GeneHancer (GH) Regulatory Elements for GET4 Gene

Promoters and enhancers for GET4 Gene