Aliases for GET4 Gene

Aliases for GET4 Gene

  • Guided Entry Of Tail-Anchored Proteins Factor 4 2 3 5
  • Transmembrane Domain Recognition Complex 35 KDa Subunit 3 4
  • Transmembrane Domain Recognition Complex, 35kDa 2 3
  • Golgi To ER Traffic Protein 4 Homolog 3 4
  • Golgi To ER Traffic Protein 4 2 3
  • Conserved Edge Protein 2 3
  • C7orf20 3 4
  • TRC35 3 4
  • CEE 3 4
  • Golgi To ER Traffic Protein 4 Homolog (S. Cerevisiae) 2
  • Chromosome 7 Open Reading Frame 20 2
  • Conserved Edge Expressed Protein 3
  • Conserved Edge-Expressed Protein 4
  • CGI-20 Protein 2
  • H_NH1244M04.5 3
  • CGI-20 3

External Ids for GET4 Gene

Previous HGNC Symbols for GET4 Gene

  • C7orf20

Previous GeneCards Identifiers for GET4 Gene

  • GC07P000916

Summaries for GET4 Gene

GeneCards Summary for GET4 Gene

GET4 (Guided Entry Of Tail-Anchored Proteins Factor 4) is a Protein Coding gene. Diseases associated with GET4 include Louping Ill and Postmenopausal Atrophic Vaginitis.

UniProtKB/Swiss-Prot Summary for GET4 Gene

  • As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).

Gene Wiki entry for GET4 Gene

Additional gene information for GET4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GET4 Gene

Genomics for GET4 Gene

GeneHancer (GH) Regulatory Elements for GET4 Gene

Promoters and enhancers for GET4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J000871 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -0.7 -714 7.7 FOXK2 ZNF217 EP300 CTCF SIN3A TCF12 MYC POLR2G USF1 SP1 GET4 DNAAF5 SUN1 ENSG00000273230 PSMG3-AS1 PRKAR1B ENSG00000229043 CYP2W1 ENSG00000242474 ENSG00000273151
GH07J000892 Promoter/Enhancer 0.8 EPDnew dbSUPER 500.4 +15.8 15847 0.1 ZFHX2 EGR2 RBFOX2 ZNF157 lnc-CYP2W1-2 GET4 ADAP1 ENSG00000225146 GPR146 C7orf50 ENSG00000273151 SUN1 RF00017-5953
GH07J000893 Promoter/Enhancer 0.7 EPDnew dbSUPER 500.4 +17.3 17305 0.1 AGO2 POLR2A lnc-CYP2W1-2 GET4 ADAP1 ENSG00000225146 GPR146 C7orf50 lnc-COX19-3 SUN1 RF00017-5953
GH07J000897 Promoter 0.6 EPDnew 500.4 +19.2 19194 0.1 POLR2G AGO2 RBM22 RBM39 POLR2A RBFOX2 GET4 lnc-CYP2W1-2 lnc-COX19-3 SUN1 RF00017-5953
GH07J000895 Promoter 0.6 EPDnew 500.4 +18.8 18809 0.1 POLR2G AGO2 RBM22 RBFOX2 GET4 lnc-CYP2W1-2 lnc-COX19-3 SUN1 RF00017-5953
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GET4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GET4

Genomic Locations for GET4 Gene

Genomic Locations for GET4 Gene
chr7:876,554-896,436
(GRCh38/hg38)
Size:
19,883 bases
Orientation:
Plus strand
chr7:916,189-936,073
(GRCh37/hg19)
Size:
19,885 bases
Orientation:
Plus strand

Genomic View for GET4 Gene

Genes around GET4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GET4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GET4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GET4 Gene

Proteins for GET4 Gene

  • Protein details for GET4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5D6-GET4_HUMAN
    Recommended name:
    Golgi to ER traffic protein 4 homolog
    Protein Accession:
    Q7L5D6
    Secondary Accessions:
    • A4D2Q1
    • B3KNC7
    • Q9UFC9
    • Q9Y309

    Protein attributes for GET4 Gene

    Size:
    327 amino acids
    Molecular mass:
    36504 Da
    Quaternary structure:
    • Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35 (PubMed:20676083, PubMed:25535373). Interacts with BAG6; the interaction is direct and localizes BAG6 to the cytosol (PubMed:21636303, PubMed:29042515, PubMed:25535373).

    Three dimensional structures from OCA and Proteopedia for GET4 Gene

    Alternative splice isoforms for GET4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GET4 Gene

Post-translational modifications for GET4 Gene

  • Ubiquitinated by RNF12, leading to proteasomal degradation. When unassembled from BAG6; ubiquitinylation is modulated by BAG6 quality control role and effectuated by RNF126.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GET4 Gene

No data available for DME Specific Peptides for GET4 Gene

Domains & Families for GET4 Gene

Gene Families for GET4 Gene

Protein Domains for GET4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GET4 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane domain recognition complex 35 kDa subunit (GET4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7L5D6

UniProtKB/Swiss-Prot:

GET4_HUMAN :
  • Belongs to the GET4 family.
Family:
  • Belongs to the GET4 family.
genes like me logo Genes that share domains with GET4: view

Function for GET4 Gene

Molecular function for GET4 Gene

UniProtKB/Swiss-Prot Function:
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).

Phenotypes From GWAS Catalog for GET4 Gene

Gene Ontology (GO) - Molecular Function for GET4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0051087 chaperone binding IPI 25535373
genes like me logo Genes that share ontologies with GET4: view
genes like me logo Genes that share phenotypes with GET4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GET4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GET4 Gene

Localization for GET4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GET4 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GET4 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GET4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 21636303
GO:0005829 cytosol IEA,IDA 20676083
GO:0071818 BAT3 complex IBA,IDA 20676083
genes like me logo Genes that share ontologies with GET4: view

Pathways & Interactions for GET4 Gene

PathCards logo

SuperPathways for GET4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GET4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045048 protein insertion into ER membrane IEA --
GO:0051220 cytoplasmic sequestering of protein IMP 21636303
GO:0071816 tail-anchored membrane protein insertion into ER membrane IMP 20676083
GO:1904378 maintenance of unfolded protein involved in ERAD pathway IMP 21636303
genes like me logo Genes that share ontologies with GET4: view

No data available for Pathways by source and SIGNOR curated interactions for GET4 Gene

Drugs & Compounds for GET4 Gene

No Compound Related Data Available

Transcripts for GET4 Gene

mRNA/cDNA for GET4 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GET4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GET4 Gene

No ASD Table

Relevant External Links for GET4 Gene

GeneLoc Exon Structure for
GET4

Expression for GET4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GET4 Gene

Protein differential expression in normal tissues from HIPED for GET4 Gene

This gene is overexpressed in Bone (24.0) and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GET4 Gene



Protein tissue co-expression partners for GET4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GET4

SOURCE GeneReport for Unigene cluster for GET4 Gene:

Hs.107387

Evidence on tissue expression from TISSUES for GET4 Gene

  • Nervous system(4)
  • Eye(2.6)
  • Blood(2.3)
  • Liver(2)
genes like me logo Genes that share expression patterns with GET4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GET4 Gene

Orthologs for GET4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GET4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GET4 31 30
  • 99.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GET4 31 30
  • 89.83 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GET4 31
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GET4 31 30
  • 87.74 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Get4 30
  • 86.83 (n)
mouse
(Mus musculus)
Mammalia Get4 17 31 30
  • 86.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GET4 31
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves GET4 31 30
  • 75.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GET4 31
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia get4 30
  • 74.71 (n)
Str.1674 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.26196 30
zebrafish
(Danio rerio)
Actinopterygii get4 31 30
  • 75.13 (n)
OneToOne
wufd15h01 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000119 30
  • 57.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9853 31 30
  • 52.43 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cee-1 31
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GET4 33 31 30
  • 40.79 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20295g 30
  • 39.32 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G63220 30
  • 44.08 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01190 30
  • 43.5 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes get4 30
  • 43.07 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2033 31
  • 38 (a)
OneToOne
Species where no ortholog for GET4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GET4 Gene

ENSEMBL:
Gene Tree for GET4 (if available)
TreeFam:
Gene Tree for GET4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GET4: view image

Paralogs for GET4 Gene

No data available for Paralogs for GET4 Gene

Variants for GET4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GET4 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
710436 Benign: not provided 892,416(+) C/T SYNONYMOUS_VARIANT
714406 Benign: not provided 892,365(+) G/A SYNONYMOUS_VARIANT
752117 Likely Benign: not provided 893,920(+) C/T SYNONYMOUS_VARIANT
785870 Benign: not provided 892,317(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for GET4 Gene

Structural Variations from Database of Genomic Variants (DGV) for GET4 Gene

Variant ID Type Subtype PubMed ID
dgv11111n54 CNV loss 21841781
esv1624512 CNV deletion 17803354
esv1790011 CNV deletion 17803354
esv24184 CNV gain+loss 19812545
esv25170 CNV loss 19812545
esv2733671 CNV deletion 23290073
esv2733673 CNV deletion 23290073
esv2733674 CNV deletion 23290073
esv2733675 CNV deletion 23290073
esv3571557 CNV loss 25503493
nsv1122151 CNV deletion 24896259
nsv1144159 CNV deletion 24896259
nsv464244 CNV loss 19166990
nsv464245 CNV gain 19166990
nsv473647 CNV novel sequence insertion 20440878
nsv509182 CNV insertion 20534489
nsv5611 CNV insertion 18451855
nsv605698 CNV loss 21841781
nsv605699 CNV loss 21841781
nsv605700 CNV gain 21841781
nsv605701 CNV gain 21841781
nsv605702 CNV loss 21841781
nsv950784 CNV deletion 24416366

Variation tolerance for GET4 Gene

Residual Variation Intolerance Score: 7.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GET4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GET4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GET4 Gene

Disorders for GET4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GET4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
louping ill
postmenopausal atrophic vaginitis
  • atrophic vaginitis
whim syndrome
  • whims
- elite association - COSMIC cancer census association via MalaCards
Search GET4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GET4

genes like me logo Genes that share disorders with GET4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GET4 Gene

Publications for GET4 Gene

  1. A ribosome-associating factor chaperones tail-anchored membrane proteins. (PMID: 20676083) Mariappan M … Hegde RS (Nature 2010) 2 3 4 54
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 54
  3. Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35. (PMID: 29042515) Mock JY … Clemons WM (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 4 54
  4. Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain. (PMID: 25535373) Mock JY … Clemons WM (Proceedings of the National Academy of Sciences of the United States of America 2015) 3 4 54
  5. A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. (PMID: 21636303) Wang Q … Ye Y (Molecular cell 2011) 3 4 54

Products for GET4 Gene

Sources for GET4 Gene