Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants... See more...
Aliases for GEMIN8 Gene
Aliases for GEMIN8 Gene
External Ids for GEMIN8 Gene
- HGNC: 26044
- Entrez Gene: 54960
- Ensembl: ENSG00000046647
- OMIM: 300962
- UniProtKB: Q9NWZ8
Previous HGNC Symbols for GEMIN8 Gene
- FAM51A1
Previous GeneCards Identifiers for GEMIN8 Gene
- GC0XM013937
- GC0XM014024
- GC0XM011782
Summaries for GEMIN8 Gene
-
The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
GeneCards Summary for GEMIN8 Gene
GEMIN8 (Gem Nuclear Organelle Associated Protein 8) is a Protein Coding gene. Diseases associated with GEMIN8 include Duodenal Obstruction and Spinal Muscular Atrophy. Among its related pathways are Transport of the SLBP independent Mature mRNA and Gene Expression.
UniProtKB/Swiss-Prot Summary for GEMIN8 Gene
-
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Additional gene information for GEMIN8 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GEMIN8 Gene
Genomics for GEMIN8 Gene
GeneHancer (GH) Regulatory Elements for GEMIN8 Gene
Promoters and enhancers for GEMIN8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GEMIN8 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GEMIN8
- Top Transcription factor binding sites by QIAGEN in the GEMIN8 gene promoter:
-
- AML1a
- C/EBPalpha
- GATA-1
- Msx-1
- Nkx3-1
- Nkx3-1 v1
- Nkx6-1
- Pbx1a
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for GEMIN8 Gene
Genomic Locations for GEMIN8 Gene
- chrX:14,002,124-14,029,916
- (GRCh38/hg38)
- Size:
- 27,793 bases
- Orientation:
- Minus strand
- chrX:14,024,845-14,048,035
- (GRCh37/hg19)
- Size:
- 23,191 bases
- Orientation:
- Minus strand
Genomic View for GEMIN8 Gene
Genes around GEMIN8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.2 by HGNC
- Xp22.2 by Entrez Gene
- Xp22.2 by Ensembl
GEMIN8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GEMIN8 Gene
Proteins for GEMIN8 Gene
-
Protein details for GEMIN8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NWZ8-GEMI8_HUMAN
- Recommended name:
- Gem-associated protein 8
- Protein Accession:
- Q9NWZ8
- C4AMC4
- Q2LJ66
- Q6ZV27
Protein attributes for GEMIN8 Gene
- Size:
- 242 amino acids
- Molecular mass:
- 28637 Da
- Quaternary structure:
-
- Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with SMN1 and with the GEMIN6-GEMIN7 heterodimer, mediating their interaction.
- SequenceCaution:
-
- Sequence=BAC86038.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for GEMIN8 Gene
Post-translational modifications for GEMIN8 Gene
Other Protein References for GEMIN8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GEMIN8 Antibody
-
Custom Antibody ServicesOriGene Antibodies for GEMIN8
- CF805788
- CF805831
- CF805832
- CF805833
- CF805834
- CF805835
- CF805836
- CF805837
- CF805967
- CF805968
- TA805788
- TA805788S
- TA805831
- TA805831S
- TA805832
- TA805832S
- TA805833
- TA805833S
- TA805834
- TA805834S
- TA805835
- TA805835S
- TA805836
- TA805836S
- TA805837
- TA805837S
- TA805967
- TA805967S
- TA805968
- TA805968S
- UM800077
- UM800077CF
- UM870077
- Novus Biologicals Antibodies for GEMIN8
-
Abcam antibodies for GEMIN8
- Invitrogen Antibodies for GEMIN8 (AFLGC-GEMIN8)
-
Biorbyt antibodies for GEMIN8
-
Santa Cruz Biotechnology (SCBT) Antibodies for GEMIN8
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for GEMIN8
- Origene Custom Protein Services for GEMIN8
-
Abcam proteins for GEMIN8
No data available for DME Specific Peptides for GEMIN8 Gene
Domains & Families for GEMIN8 Gene
Gene Families for GEMIN8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for GEMIN8 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein FAM51A1 (GEMI8_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GEMIN8 Gene
Function for GEMIN8 Gene
Molecular function for GEMIN8 Gene
- UniProtKB/Swiss-Prot Function:
- The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17023415 |
Phenotypes for GEMIN8 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GEMIN8 - Select products 50% OFF >
- * GEMIN8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * GEMIN8 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for GEMIN8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GEMIN8
- genomics-online: gRNA clones - Search for available GEMIN8 gRNA products
- Overview of 141 available GEMIN8 gene related products
-
Recommended
-
Santa Cruz Biotechnology (SCBT) CRISPR for GEMIN8
miRNA for GEMIN8 Gene
- miRTarBase miRNAs that target GEMIN8
-
- hsa-mir-5589-5p (MIRT688114)
- hsa-mir-4731-5p (MIRT688115)
- hsa-mir-6778-3p (MIRT688116)
- hsa-mir-7107-5p (MIRT688117)
- hsa-mir-1234-3p (MIRT688118)
- hsa-mir-186-3p (MIRT688119)
- hsa-mir-520h (MIRT688120)
- hsa-mir-520g-3p (MIRT688121)
- hsa-mir-512-3p (MIRT688122)
- hsa-mir-520e (MIRT688123)
- hsa-mir-520d-3p (MIRT688124)
- hsa-mir-520c-3p (MIRT688125)
- hsa-mir-520b (MIRT688126)
- hsa-mir-520a-3p (MIRT688127)
- hsa-mir-373-3p (MIRT688128)
- hsa-mir-372-3p (MIRT688129)
- hsa-mir-302e (MIRT688130)
- hsa-mir-302d-3p (MIRT688131)
- hsa-mir-302c-3p (MIRT688132)
- hsa-mir-302b-3p (MIRT688133)
- hsa-mir-302a-3p (MIRT688134)
- hsa-mir-93-5p (MIRT688135)
- hsa-mir-526b-3p (MIRT688136)
- hsa-mir-519d-3p (MIRT688137)
- hsa-mir-20b-5p (MIRT688138)
- hsa-mir-20a-5p (MIRT688139)
- hsa-mir-17-5p (MIRT688140)
- hsa-mir-106b-5p (MIRT688141)
- hsa-mir-106a-5p (MIRT688142)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GEMIN8
- Browse OriGene Inhibitory RNA Products For GEMIN8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GEMIN8
- genomics-online: shRNA clones - Search for available GEMIN8 shRNA products
- Overview of 141 available GEMIN8 gene related products
-
Recommended
Clone Products
- Applied Biological Materials (abm): Clones for GEMIN8 - Select products 50% OFF >
- * GEMIN8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * GEMIN8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- RC200165
- RC204795
- RC213444
- RG200165
- RG204795
- RG213444
- MR202283
- MG202283
- RR204723
- RC200165L3
- RC200165L3V
- RC200165L4
- RC200165L4V
- RC204795L3
- RC204795L3V
- RC204795L4
- RC204795L4V
- RC213444L3
- RC213444L3V
- RC213444L4
- RC213444L4V
- MR202283L3
- MR202283L3V
- MR202283L4
- MR202283L4V
- RR204723L3
- RR204723L3V
- RR204723L4
- RR204723L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GEMIN8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GEMIN8
- genomics-online: cdna clones - Search for available GEMIN8 CDNA products
- Overview of 141 available GEMIN8 gene related products
-
Recommended
- orf clones - Search for available GEMIN8 ORF products
- Overview of 141 available GEMIN8 gene related products
-
Recommended
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GEMIN8 Gene
Localization for GEMIN8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GEMIN8 Gene
- Nucleus, gem. Cytoplasm. Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| peroxisome | 0 |
- Cytosol (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 16434402 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 17023415 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0032797 | SMN complex | IEA,IDA | 16434402 |
Pathways & Interactions for GEMIN8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of the SLBP independent Mature mRNA |
.55
|
|
| 2 | RNA transport | ||
| 3 | Gene Expression |
.48
|
|
Pathways by source for GEMIN8 Gene
3 Reactome pathways for GEMIN8 Gene
1 KEGG pathway for GEMIN8 Gene
Interacting Proteins for GEMIN8 Gene
Selected Interacting proteins:
Q9NWZ8-GEMI8_HUMAN
ENSP00000369895
for GEMIN8 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for GEMIN8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000387 | spliceosomal snRNP assembly | TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | IEA | -- |
| GO:0051170 | import into nucleus | TAS | -- |
No data available for SIGNOR curated interactions for GEMIN8 Gene
Transcripts for GEMIN8 Gene
mRNA/cDNA for GEMIN8 Gene
- 3 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000332885 868 bps (ENST00000332885.7)
- ENST00000380523 1682 bps (ENST00000380523.8)
- ENST00000398355 1119 bps (ENST00000398355.7)
- ENST00000460203 839 bps (ENST00000460203.1)
- ENST00000477386 724 bps (ENST00000477386.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GEMIN8 - Select products 50% OFF >
- * GEMIN8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * GEMIN8 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for GEMIN8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GEMIN8
- genomics-online: gRNA clones - Search for available GEMIN8 gRNA products
- Overview of 141 available GEMIN8 gene related products
-
Recommended
-
Santa Cruz Biotechnology (SCBT) CRISPR for GEMIN8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GEMIN8
- Browse OriGene Inhibitory RNA Products For GEMIN8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GEMIN8
- genomics-online: shRNA clones - Search for available GEMIN8 shRNA products
- Overview of 141 available GEMIN8 gene related products
-
Recommended
Clone Products
- Applied Biological Materials (abm): Clones for GEMIN8 - Select products 50% OFF >
- * GEMIN8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * GEMIN8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- RC200165
- RC204795
- RC213444
- RG200165
- RG204795
- RG213444
- MR202283
- MG202283
- RR204723
- RC200165L3
- RC200165L3V
- RC200165L4
- RC200165L4V
- RC204795L3
- RC204795L3V
- RC204795L4
- RC204795L4V
- RC213444L3
- RC213444L3V
- RC213444L4
- RC213444L4V
- MR202283L3
- MR202283L3V
- MR202283L4
- MR202283L4V
- RR204723L3
- RR204723L3V
- RR204723L4
- RR204723L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GEMIN8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GEMIN8
- genomics-online: cdna clones - Search for available GEMIN8 CDNA products
- Overview of 141 available GEMIN8 gene related products
-
Recommended
- orf clones - Search for available GEMIN8 ORF products
- Overview of 141 available GEMIN8 gene related products
-
Recommended
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||
| SP9: |
Relevant External Links for GEMIN8 Gene
- GeneLoc Exon Structure for
- GEMIN8
Expression for GEMIN8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
This gene is overexpressed in Bone (57.9) and Pancreas (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GEMIN8 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GEMIN8
SOURCE GeneReport for Unigene cluster for GEMIN8 Gene:
Hs.592237Evidence on tissue expression from TISSUES for GEMIN8 Gene
- Nervous system(4.4)
- Intestine(4.2)
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs for GEMIN8
-
OriGene qPCR primer pairs and template standards for GEMIN8
- genomics-online: primer clones - Search for available GEMIN8 Primer products
- Overview of 141 available GEMIN8 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GEMIN8 Gene
Orthologs for GEMIN8 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GEMIN8 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GEMIN8 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Gemin8 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Gemin8 17 31 30 |
|
||
| cow (Bos Taurus) |
Mammalia | GEMIN8 31 30 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GEMIN8 31 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GEMIN8 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GEMIN8 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GEMIN8 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gemin8 30 |
|
||
| Str.521 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.4507 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gemin8 31 30 |
|
OneToOne | |
| wufd13g07 30 |
|
- Species where no ortholog for GEMIN8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for GEMIN8 Gene
- ENSEMBL:
- Gene Tree for GEMIN8 (if available)
- TreeFam:
- Gene Tree for GEMIN8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GEMIN8: view image
Paralogs for GEMIN8 Gene
Pseudogenes.org Pseudogenes for GEMIN8 Gene
No data available for Paralogs for GEMIN8 Gene
Variants for GEMIN8 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GEMIN8 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs3747421 | - | p.Glu195Val |
Residual Variation Intolerance Score:
57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.05;
50.48% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GEMIN8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GEMIN8
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GEMIN8 Gene
Disorders for GEMIN8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| duodenal obstruction |
|
|
| spinal muscular atrophy |
|
|
| amyotrophic lateral sclerosis 1 |
|
|
Search GEMIN8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GEMIN8
No data available for UniProtKB/Swiss-Prot and Genatlas for GEMIN8 Gene
Publications for GEMIN8 Gene
- Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly. (PMID: 16434402) Carissimi C … Pellizzoni L (The Journal of biological chemistry 2006) 2 3 4 54
- An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PMID: 18984161) Chari A … Fischer U (Cell 2008) 3 4 54
- Gemin8 is required for the architecture and function of the survival motor neuron complex. (PMID: 17023415) Carissimi C … Pellizzoni L (The Journal of biological chemistry 2006) 3 4 54
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
ExternalLinks
Products for GEMIN8 Gene
- Custom Antibody ServicesOriGene Antibodies for GEMIN8
- CF805788
- CF805831
- CF805832
- CF805833
- CF805834
- CF805835
- CF805836
- CF805837
- CF805967
- CF805968
- TA805788
- TA805788S
- TA805831
- TA805831S
- TA805832
- TA805832S
- TA805833
- TA805833S
- TA805834
- TA805834S
- TA805835
- TA805835S
- TA805836
- TA805836S
- TA805837
- TA805837S
- TA805967
- TA805967S
- TA805968
- TA805968S
- UM800077
- UM800077CF
- UM870077
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for GEMIN8
- Origene Custom Protein Services for GEMIN8
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GEMIN8
- Browse OriGene Inhibitory RNA Products For GEMIN8
- OriGene qPCR primer pairs for GEMIN8
- OriGene qPCR primer pairs and template standards for GEMIN8
- OriGene CRISPR knockouts for GEMIN8
- RC200165
- RC204795
- RC213444
- RG200165
- RG204795
- RG213444
- MR202283
- MG202283
- RR204723
- RC200165L3
- RC200165L3V
- RC200165L4
- RC200165L4V
- RC204795L3
- RC204795L3V
- RC204795L4
- RC204795L4V
- RC213444L3
- RC213444L3V
- RC213444L4
- RC213444L4V
- MR202283L3
- MR202283L3V
- MR202283L4
- MR202283L4V
- RR204723L3
- RR204723L3V
- RR204723L4
- RR204723L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GEMIN8
- Sino Biological Human cDNA Clone for GEMIN8
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GEMIN8
- Novus Biologicals proteins and lysates for GEMIN8
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for GEMIN8
- Abcam proteins for GEMIN8
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for GEMIN8 (AFLGC-GEMIN8)
- antibodies-online: Show 18 available GEMIN8 Antibodies ranked by validation data
- Compare Top GEMIN8 Antibodies
- antibodies-online: Search results for available GEMIN8 related products ranked by validation data
- antibodies-online: Show 7 available GEMIN8 Proteins ranked by validation data
- Compare Top GEMIN8 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for GEMIN8
- Search Santa Cruz Biotechnology (SCBT) for GEMIN8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GEMIN8
- genomics-online: cdna clones - Search for available GEMIN8 CDNA products
- Overview of 141 available GEMIN8 gene related products
- Recommended
- orf clones - Search for available GEMIN8 ORF products
- Overview of 141 available GEMIN8 gene related products
- Recommended
- genomics-online: gRNA clones - Search for available GEMIN8 gRNA products
- Overview of 141 available GEMIN8 gene related products
- Recommended
- genomics-online: primer clones - Search for available GEMIN8 Primer products
- Overview of 141 available GEMIN8 gene related products
- Recommended
- genomics-online: shRNA clones - Search for available GEMIN8 shRNA products
- Overview of 141 available GEMIN8 gene related products
- Recommended
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GEMIN8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GEMIN8
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GEMIN8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GEMIN8
- Biorbyt antibodies for GEMIN8
Sources for GEMIN8 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource