Aliases for GEMIN8 Gene
Aliases for GEMIN8 Gene
External Ids for GEMIN8 Gene
- HGNC: 26044
- Entrez Gene: 54960
- Ensembl: ENSG00000046647
- OMIM: 300962
- UniProtKB: Q9NWZ8
Previous HGNC Symbols for GEMIN8 Gene
- FAM51A1
Previous GeneCards Identifiers for GEMIN8 Gene
- GC0XM013937
- GC0XM011782
Summaries for GEMIN8 Gene
-
The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
GeneCards Summary for GEMIN8 Gene
GEMIN8 (Gem Nuclear Organelle Associated Protein 8) is a Protein Coding gene. Diseases associated with GEMIN8 include Spinal Muscular Atrophy. Among its related pathways are Transport of the SLBP independent Mature mRNA and RNA transport.
UniProtKB/Swiss-Prot for GEMIN8 Gene
-
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Additional gene information for GEMIN8 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GEMIN8 Gene
Genomics for GEMIN8 Gene
GeneHancer (GH) Regulatory Elements for GEMIN8 Gene
Promoters and enhancers for GEMIN8 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XJ014027 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 693.1 | +1.1 | 1066 | 4.1 | PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 POLR2B | GEMIN8 GPM6B LOC105373138 | |
| GH0XJ013936 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE dbSUPER | 21.6 | +91.3 | 91342 | 3.5 | KLF17 FEZF1 KLF14 ZNF335 GLIS2 ZNF213 SCRT2 EGR2 SP3 ZNF362 | GPM6B GEMIN8 GC0XM013757 | |
| GH0XJ013647 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE | 22.6 | +382.0 | 381996 | 1.8 | PKNOX1 SMAD1 FOXA2 ARNT POLR2B ZNF766 FOS ZNF662 ZNF592 MEF2D | GEMIN8 TCEANC RAB9A RN7SKP20 | |
| GH0XJ014032 | Enhancer | 0.8 | Ensembl ENCODE | 41.4 | -2.9 | -2907 | 1.2 | CTCF ZNF654 ZNF10 TRIM22 MZF1 REST ZNF501 RAD21 YY1 ARID2 | GEMIN8 GC0XP014112 | |
| GH0XJ013902 | Enhancer | 0.5 | dbSUPER | 20.2 | +126.8 | 126804 | 2.1 | GLIS1 ZNF140 MZF1 PRDM10 ZNF600 ZIC2 | GEMIN8 OFD1 GPM6B GC0XM013757 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GEMIN8 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GEMIN8 gene promoter:
-
- GATA-1
- PPAR-gamma2
- PPAR-gamma1
- Msx-1
- AML1a
- Nkx6-1
- Pbx1a
- C/EBPalpha
- Nkx3-1
- Nkx3-1 v1
Regulatory Element Products
Genomic Locations for GEMIN8 Gene
Genomic Locations for GEMIN8 Gene
- chrX:14,002,124-14,029,916
- (GRCh38/hg38)
- Size:
- 27,793 bases
- Orientation:
- Minus strand
- chrX:14,024,845-14,048,035
- (GRCh37/hg19)
- Size:
- 23,191 bases
- Orientation:
- Minus strand
Genomic View for GEMIN8 Gene
Genes around GEMIN8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.2 by Entrez Gene
- Xp22.2 by HGNC
- Xp22.2 by Ensembl
GEMIN8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GEMIN8 Gene
Proteins for GEMIN8 Gene
-
Protein details for GEMIN8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NWZ8-GEMI8_HUMAN
- Recommended name:
- Gem-associated protein 8
- Protein Accession:
- Q9NWZ8
- C4AMC4
- Q2LJ66
- Q6ZV27
Protein attributes for GEMIN8 Gene
- Size:
- 242 amino acids
- Molecular mass:
- 28637 Da
- Quaternary structure:
-
- Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with SMN1 and with the GEMIN6-GEMIN7 heterodimer, mediating their interaction.
- SequenceCaution:
-
- Sequence=BAC86038.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for GEMIN8 Gene
Post-translational modifications for GEMIN8 Gene
Other Protein References for GEMIN8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GEMIN8
-
Abcam antibodies for GEMIN8
- Invitrogen Antibodies for GEMIN8
- Search GeneTex for Antibodies for GEMIN8
-
Santa Cruz Biotechnology (SCBT) Antibodies for GEMIN8
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for GEMIN8
- Origene Custom Protein Services for GEMIN8
- Search GeneTex for Proteins for GEMIN8
-
Abcam proteins for GEMIN8
Assay Products
No data available for DME Specific Peptides for GEMIN8 Gene
Domains & Families for GEMIN8 Gene
Gene Families for GEMIN8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for GEMIN8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for GEMIN8 Gene
Function for GEMIN8 Gene
Molecular function for GEMIN8 Gene
- UniProtKB/Swiss-Prot Function:
- The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17023415 |
Phenotypes for GEMIN8 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GEMIN8
-
CRISPR Products
-
OriGene CRISPR knockouts for GEMIN8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GEMIN8
- genomics-online: gRNA clones - Search results for 125 available GEMIN8 gene related products
- Overview of 125 available GEMIN8 gene related products
- Applied Biological Materials CRISPR for GEMIN8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GEMIN8
- GenScript: Design CRISPR guide RNA sequences for GEMIN8
miRNA for GEMIN8 Gene
- miRTarBase miRNAs that target GEMIN8
-
- hsa-mir-5589-5p (MIRT688114)
- hsa-mir-4731-5p (MIRT688115)
- hsa-mir-6778-3p (MIRT688116)
- hsa-mir-7107-5p (MIRT688117)
- hsa-mir-1234-3p (MIRT688118)
- hsa-mir-186-3p (MIRT688119)
- hsa-mir-520h (MIRT688120)
- hsa-mir-520g-3p (MIRT688121)
- hsa-mir-512-3p (MIRT688122)
- hsa-mir-520e (MIRT688123)
- hsa-mir-520d-3p (MIRT688124)
- hsa-mir-520c-3p (MIRT688125)
- hsa-mir-520b (MIRT688126)
- hsa-mir-520a-3p (MIRT688127)
- hsa-mir-373-3p (MIRT688128)
- hsa-mir-372-3p (MIRT688129)
- hsa-mir-302e (MIRT688130)
- hsa-mir-302d-3p (MIRT688131)
- hsa-mir-302c-3p (MIRT688132)
- hsa-mir-302b-3p (MIRT688133)
- hsa-mir-302a-3p (MIRT688134)
- hsa-mir-93-5p (MIRT688135)
- hsa-mir-526b-3p (MIRT688136)
- hsa-mir-519d-3p (MIRT688137)
- hsa-mir-20b-5p (MIRT688138)
- hsa-mir-20a-5p (MIRT688139)
- hsa-mir-17-5p (MIRT688140)
- hsa-mir-106b-5p (MIRT688141)
- hsa-mir-106a-5p (MIRT688142)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GEMIN8
- Browse OriGene Inhibitory RNA Products For GEMIN8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GEMIN8
- genomics-online: shRNA clones - Search results for 125 available GEMIN8 gene related products
- Overview of 125 available GEMIN8 gene related products
Clone Products
-
OriGene ORF clones in human for GEMIN8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GEMIN8
- VectorBuilder custom plasmid, inducible vectors for GEMIN8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GEMIN8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GEMIN8
- Applied Biological Materials Clones for GEMIN8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GEMIN8 Gene
Localization for GEMIN8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GEMIN8 Gene
- Nucleus, gem. Cytoplasm. Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| peroxisome | 1 |
- Cytosol (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 16434402 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 17023415 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0032797 | SMN complex | IDA,IEA | 16434402 |
Pathways & Interactions for GEMIN8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of the SLBP independent Mature mRNA |
.55
|
|
| 2 | RNA transport | ||
| 3 | Gene Expression |
.48
|
|
Pathways by source for GEMIN8 Gene
3 Reactome pathways for GEMIN8 Gene
1 KEGG pathway for GEMIN8 Gene
Interacting Proteins for GEMIN8 Gene
Selected Interacting proteins:
ENSP00000369895
Q9NWZ8-GEMI8_HUMAN
for GEMIN8 Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for GEMIN8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000387 | spliceosomal snRNP assembly | TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | IEA | -- |
| GO:0051170 | import into nucleus | TAS | -- |
No data available for SIGNOR curated interactions for GEMIN8 Gene
Transcripts for GEMIN8 Gene
mRNA/cDNA for GEMIN8 Gene
- (6) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (119) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000380523 1682 bps (uc004cwb.4)
- ENST00000398355 1119 bps (uc004cwd.4)
- ENST00000332885 868 bps (uc064ybq.1)
- ENST00000460203 839 bps (uc064ybr.1)
- ENST00000477386 724 bps (uc064ybs.1)
Unigene Clusters for GEMIN8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GEMIN8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GEMIN8
- genomics-online: gRNA clones - Search results for 125 available GEMIN8 gene related products
- Overview of 125 available GEMIN8 gene related products
- Applied Biological Materials CRISPR for GEMIN8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GEMIN8
- GenScript: Design CRISPR guide RNA sequences for GEMIN8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GEMIN8
- Browse OriGene Inhibitory RNA Products For GEMIN8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GEMIN8
- genomics-online: shRNA clones - Search results for 125 available GEMIN8 gene related products
- Overview of 125 available GEMIN8 gene related products
Clone Products
-
OriGene ORF clones in human for GEMIN8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GEMIN8
- VectorBuilder custom plasmid, inducible vectors for GEMIN8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GEMIN8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GEMIN8
- Applied Biological Materials Clones for GEMIN8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for GEMIN8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
This gene is overexpressed in Bone (57.9) and Pancreas (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GEMIN8 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GEMIN8 Gene:
GEMIN8SOURCE GeneReport for Unigene cluster for GEMIN8 Gene:
Hs.592237Evidence on tissue expression from TISSUES for GEMIN8 Gene
- Nervous system(4.4)
- Intestine(4.2)
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for GEMIN8
-
OriGene qPCR primer pairs for GEMIN8
- genomics-online: primer clones - Search results for 125 available GEMIN8 gene related products
- Overview of 125 available GEMIN8 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GEMIN8 Gene
Orthologs for GEMIN8 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GEMIN8 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GEMIN8 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Gemin8 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Gemin8 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | GEMIN8 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GEMIN8 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GEMIN8 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GEMIN8 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GEMIN8 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gemin8 33 |
|
||
| Str.521 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.4507 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gemin8 34 33 |
|
OneToOne | |
| wufd13g07 33 |
|
- Species where no ortholog for GEMIN8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for GEMIN8 Gene
- ENSEMBL:
- Gene Tree for GEMIN8 (if available)
- TreeFam:
- Gene Tree for GEMIN8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GEMIN8: view image
Paralogs for GEMIN8 Gene
Pseudogenes.org Pseudogenes for GEMIN8 Gene
No data available for Paralogs for GEMIN8 Gene
Variants for GEMIN8 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000008808 | -- | 14,025,345(-) | A/C | intron_variant | |
| rs1000024501 | -- | 14,015,445(-) | G/C | intron_variant | |
| rs1000088241 | -- | 14,013,512(-) | T/C | intron_variant | |
| rs1000196480 | -- | 14,006,939(-) | G/A | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
| rs1000521588 | -- | 14,016,024(-) | T/C | intron_variant |
Residual Variation Intolerance Score:
57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.05;
50.48% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GEMIN8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GEMIN8
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GEMIN8 Gene
Disorders for GEMIN8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinal muscular atrophy |
|
|
Search GEMIN8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GEMIN8
No data available for UniProtKB/Swiss-Prot and Genatlas for GEMIN8 Gene
Publications for GEMIN8 Gene
- Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly. (PMID: 16434402) Carissimi C … Pellizzoni L (The Journal of biological chemistry 2006) 2 3 4 58
- An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PMID: 18984161) Chari A … Fischer U (Cell 2008) 3 4 58
- Gemin8 is required for the architecture and function of the survival motor neuron complex. (PMID: 17023415) Carissimi C … Pellizzoni L (The Journal of biological chemistry 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for GEMIN8 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for GEMIN8
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for GEMIN8
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- OriGene qPCR primer pairs and template standards for GEMIN8
- OriGene qPCR primer pairs for GEMIN8
- OriGene CRISPR knockouts for GEMIN8
- OriGene ORF clones in human for GEMIN8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GEMIN8
- GenScript: Next-day shipping of latest version cDNA ORF clones for GEMIN8 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for GEMIN8
- GenScript Custom Assay Services for GEMIN8
- GenScript Custom overexpressing Cell Line Services for GEMIN8
- GenScript: Design CRISPR guide RNA sequences for GEMIN8
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for GEMIN8
- Sino Biological Human cDNA Clone for GEMIN8
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GEMIN8
- Novus Biologicals lysates and proteins for GEMIN8
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for GEMIN8
- Abcam proteins for GEMIN8
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cyagen custom Knockout/knockin (KOKI) mouse models for GEMIN8
- VectorBuilder custom plasmid, inducible vectors for GEMIN8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GEMIN8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 46 available GEMIN8 Antibodies ranked by validation data
- Compare Top GEMIN8 Antibodies
- antibodies-online: Search results for available GEMIN8 related products ranked by validation data
- antibodies-online: Search results for 7 available GEMIN8 Proteins ranked by validation data
- Compare Top GEMIN8 Proteins
- Search GeneTex for Antibodies for GEMIN8
- Search GeneTex for Proteins for GEMIN8
- Santa Cruz Biotechnology (SCBT) Antibodies for GEMIN8
- Search Santa Cruz Biotechnology (SCBT) for GEMIN8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GEMIN8
- genomics-online: cdna clones - Search results for 125 available GEMIN8 gene related products
- Overview of 125 available GEMIN8 gene related products
- orf clones - Search results for 125 available GEMIN8 gene related products
- Overview of 125 available GEMIN8 gene related products
- genomics-online: gRNA clones - Search results for 125 available GEMIN8 gene related products
- Overview of 125 available GEMIN8 gene related products
- genomics-online: primer clones - Search results for 125 available GEMIN8 gene related products
- Overview of 125 available GEMIN8 gene related products
- genomics-online: shRNA clones - Search results for 125 available GEMIN8 gene related products
- Overview of 125 available GEMIN8 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GEMIN8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GEMIN8
- GeneCopoeia miRNA 3'UTR Target clone products for GEMIN8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GEMIN8
Sources for GEMIN8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt