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Aliases for GDPGP1 Gene

Aliases for GDPGP1 Gene

  • GDP-D-Glucose Phosphorylase 1 2 3 5
  • C15orf58 3 4
  • GDP-D-Glucose Phosphorylase C15orf58 3
  • Chromosome 15 Open Reading Frame 58 2
  • EC 2.7.7.78 4
  • VTC2 3

External Ids for GDPGP1 Gene

Previous HGNC Symbols for GDPGP1 Gene

  • C15orf58

Previous GeneCards Identifiers for GDPGP1 Gene

  • GC15P090778

Summaries for GDPGP1 Gene

GeneCards Summary for GDPGP1 Gene

GDPGP1 (GDP-D-Glucose Phosphorylase 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleotide binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is ENSG00000284626.

UniProtKB/Swiss-Prot for GDPGP1 Gene

  • Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

Additional gene information for GDPGP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDPGP1 Gene

Genomics for GDPGP1 Gene

GeneHancer (GH) Regulatory Elements for GDPGP1 Gene

Promoters and enhancers for GDPGP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I090229 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.5 -1503 6.1 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CIB1 ENSG00000284626 GDPGP1 PIR48569 ENSG00000259212 ENSG00000259314 UNC45A POLG FANCI TICRR
GH15I090263 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.3 +31.9 31941 3.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF766 CIB1 ENSG00000275674 NGRN ENSG00000228998 TTLL13P ARPIN RPL36AP43 NIFKP5 GDPGP1 GABARAPL3
GH15I090094 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10 -133.7 -133673 11.2 HDGF PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A IRF4 YY1 ZNF207 ZNF143 IDH2 ENSG00000259314 UNC45A POLG LOC100631255 ENSG00000259212 FANCI NGRN GDPGP1 IDH2-DT
GH15I090157 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -70.3 -70266 12.2 CLOCK MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 UNC45A CIB1 ENSG00000259314 POLG RCCD1 SEMA4B LOC100631255 RPL36AP43 GDPGP1 NGRN
GH15I090361 Enhancer 1.3 Ensembl ENCODE dbSUPER 15.2 +129.5 129526 4.1 ATF1 BRCA1 RAD21 ZBTB40 RFX5 ZNF766 ZNF143 RCOR1 FOS RUNX3 GC15M090347 IQGAP1 GDPGP1 NGRN CRTC3 ZNF774 CIB1 PEX11A GC15P090381
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GDPGP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GDPGP1 Gene

Genomic Locations for GDPGP1 Gene
chr15:90,233,808-90,245,811
(GRCh38/hg38)
Size:
12,004 bases
Orientation:
Plus strand
chr15:90,777,040-90,785,315
(GRCh37/hg19)

Genomic View for GDPGP1 Gene

Genes around GDPGP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDPGP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDPGP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDPGP1 Gene

Proteins for GDPGP1 Gene

  • Protein details for GDPGP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNW5-GDPP1_HUMAN
    Recommended name:
    GDP-D-glucose phosphorylase 1
    Protein Accession:
    Q6ZNW5

    Protein attributes for GDPGP1 Gene

    Size:
    385 amino acids
    Molecular mass:
    42362 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The orthologs in A.thaliana are GDP-L-galactose phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

neXtProt entry for GDPGP1 Gene

Post-translational modifications for GDPGP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GDPGP1 Gene

No data available for DME Specific Peptides for GDPGP1 Gene

Domains & Families for GDPGP1 Gene

Gene Families for GDPGP1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GDPGP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GDPGP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZNW5

UniProtKB/Swiss-Prot:

GDPP1_HUMAN :
  • Belongs to the GDPGP1 family.
Family:
  • Belongs to the GDPGP1 family.
genes like me logo Genes that share domains with GDPGP1: view

Function for GDPGP1 Gene

Molecular function for GDPGP1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2 uM for GDP-D-glucose (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; KM=12 uM for GDP-L-galactose (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; KM=42 uM for GDP-D-mannose (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; KM=2.9 mM for inorganic phosphate (at 31 degrees Celsius) {ECO:0000269 PubMed:21507950}; Note=kcat is 26 s(-1) at 31 degrees Celsius. The catalytic efficiency for GDP-D-glucose is 35-fold higher than for GDP-L- galactose.;
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP.
UniProtKB/Swiss-Prot Function:
Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

Enzyme Numbers (IUBMB) for GDPGP1 Gene

Gene Ontology (GO) - Molecular Function for GDPGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GDPGP1: view
genes like me logo Genes that share phenotypes with GDPGP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GDPGP1 Gene

Localization for GDPGP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDPGP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GDPGP1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GDPGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS,IBA --
genes like me logo Genes that share ontologies with GDPGP1: view

Pathways & Interactions for GDPGP1 Gene

SuperPathways for GDPGP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GDPGP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process IMP 21507950
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with GDPGP1: view

No data available for Pathways by source and SIGNOR curated interactions for GDPGP1 Gene

Drugs & Compounds for GDPGP1 Gene

(3) Drugs for GDPGP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Glucose 1-phosphate Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0

(1) Additional Compounds for GDPGP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-glucose
  • GDP-alpha-D-Glucose
  • GDP-alpha-delta-Glucose
  • GDPG
  • Guanosine 5-pyrophosphate
  • Guanosine diphosphoglucose
5750-57-2
genes like me logo Genes that share compounds with GDPGP1: view

Transcripts for GDPGP1 Gene

mRNA/cDNA for GDPGP1 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GDPGP1 Gene

GDP-D-glucose phosphorylase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GDPGP1 Gene

No ASD Table

Relevant External Links for GDPGP1 Gene

GeneLoc Exon Structure for
GDPGP1
ECgene alternative splicing isoforms for
GDPGP1

Expression for GDPGP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GDPGP1 Gene

Protein differential expression in normal tissues from HIPED for GDPGP1 Gene

This gene is overexpressed in Spleen (11.8), Salivary gland (9.0), Stomach (7.9), and Skin (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GDPGP1 Gene



Protein tissue co-expression partners for GDPGP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GDPGP1 Gene:

GDPGP1

SOURCE GeneReport for Unigene cluster for GDPGP1 Gene:

Hs.304673
genes like me logo Genes that share expression patterns with GDPGP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GDPGP1 Gene

Orthologs for GDPGP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GDPGP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GDPGP1 33 34
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia GDPGP1 33 34
  • 85.19 (n)
cow
(Bos Taurus)
Mammalia GDPGP1 33 34
  • 84.16 (n)
rat
(Rattus norvegicus)
Mammalia Gdpgp1 33
  • 80.64 (n)
mouse
(Mus musculus)
Mammalia Gdpgp1 33 16 34
  • 79.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GDPGP1 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858151 33
  • 59.88 (n)
GDPGP1 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gdpgp1 33
  • 54.42 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:153343 33
  • 55.16 (n)
GDPGP1 34
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000740 33
  • 48.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3552 33 34
  • 45.3 (n)
worm
(Caenorhabditis elegans)
Secernentea mcp-1 33 34
  • 41.75 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons VTC5 33
  • 44.37 (n)
rice
(Oryza sativa)
Liliopsida Os12g0190000 33
  • 47.1 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
OneToOne
Species where no ortholog for GDPGP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GDPGP1 Gene

ENSEMBL:
Gene Tree for GDPGP1 (if available)
TreeFam:
Gene Tree for GDPGP1 (if available)

Paralogs for GDPGP1 Gene

Paralogs for GDPGP1 Gene

(1) SIMAP similar genes for GDPGP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GDPGP1: view

Variants for GDPGP1 Gene

Sequence variations from dbSNP and Humsavar for GDPGP1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000076565 -- 90,233,564(+) C/G upstream_transcript_variant
rs1000472786 -- 90,234,979(+) A/G intron_variant
rs1000868902 -- 90,234,174(+) G/C upstream_transcript_variant
rs1000884319 -- 90,237,821(+) A/C intron_variant
rs1000915361 -- 90,238,042(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GDPGP1 Gene

Variant ID Type Subtype PubMed ID
dgv112e55 CNV gain 17911159
esv2760054 CNV gain 17122850
esv3637214 CNV gain 21293372
nsv1052652 CNV gain 25217958
nsv442384 CNV gain 18776908
nsv817707 CNV gain 17921354
nsv833087 CNV loss 17160897

Variation tolerance for GDPGP1 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.77; 83.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GDPGP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GDPGP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDPGP1 Gene

Disorders for GDPGP1 Gene

Additional Disease Information for GDPGP1

No disorders were found for GDPGP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GDPGP1 Gene

Publications for GDPGP1 Gene

  1. A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. (PMID: 21507950) Adler LN … Linster CL (The Journal of biological chemistry 2011) 2 3 4 58
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for GDPGP1 Gene

Sources for GDPGP1 Gene

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