Aliases for GDPD4 Gene

Aliases for GDPD4 Gene

  • Glycerophosphodiester Phosphodiesterase Domain Containing 4 2 3 5
  • Glycerophosphodiester Phosphodiesterase Domain-Containing Protein 4 3 4
  • Glycerophosphodiester Phosphodiesterase 6 3 4
  • UgpQ 3 4
  • GDE6 3 4
  • GDPD Domain Containing Protein 3
  • EC 3.1.-.- 4
  • UGPQ 4

External Ids for GDPD4 Gene

Previous GeneCards Identifiers for GDPD4 Gene

  • GC11M076606
  • GC11M076927
  • GC11M073225

Summaries for GDPD4 Gene

GeneCards Summary for GDPD4 Gene

GDPD4 (Glycerophosphodiester Phosphodiesterase Domain Containing 4) is a Protein Coding gene. Diseases associated with GDPD4 include Salivary Gland Disease. Gene Ontology (GO) annotations related to this gene include phosphoric diester hydrolase activity and glycerophosphodiester phosphodiesterase activity. An important paralog of this gene is GDPD5.

Additional gene information for GDPD4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GDPD4 Gene

Genomics for GDPD4 Gene

GeneHancer (GH) Regulatory Elements for GDPD4 Gene

Promoters and enhancers for GDPD4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J077298 Enhancer 1.1 Ensembl ENCODE 521.4 +1.8 1810 1.8 AFF1 TARDBP RFX1 CUX1 TOE1 CTBP1 HINFP TBX3 ZSCAN9 CREB1 GDPD4 TOMM20P1 lnc-GDPD4-3 piR-48348-008 CAPN5
GH11J077304 Enhancer 0.4 Ensembl 509.2 +0.6 598 0.2 FOXA2 FOSL2 ID3 GDPD4 TOMM20P1 lnc-GDPD4-3
GH11J077301 Promoter 0.3 EPDnew 500.7 0.0 -7 0.1 GDPD4 TOMM20P1 lnc-GDPD4-3 lnc-MYO7A-2
GH11J077410 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 24.5 -109.8 -109761 3.3 PHF8 POLR2A ZBTB26 CTCF SAP30 HDAC2 ZNF341 OSR2 DEK MYC PAK1 lnc-GDPD4-7 GDPD4 AQP11 lnc-GDPD4-6
GH11J077469 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 15.3 -171.1 -171065 7.4 HNRNPK ZBTB40 ZNF217 EP300 CTCF ZSCAN5C MYC USF1 PHF8 JUND PAK1 ENSG00000268635 RSF1 GDPD4 ENSG00000241782 ENSG00000254459 AQP11 MYO7A lnc-PAK1-1 lnc-GDPD4-7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GDPD4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GDPD4

Top Transcription factor binding sites by QIAGEN in the GDPD4 gene promoter:
  • AML1a
  • C/EBPalpha
  • COMP1
  • FOXO4
  • HFH-1
  • HSF1 (long)
  • HSF1short
  • NCX
  • Pbx1a
  • STAT3

Genomic Locations for GDPD4 Gene

Genomic Locations for GDPD4 Gene
85,142 bases
Minus strand
85,130 bases
Minus strand

Genomic View for GDPD4 Gene

Genes around GDPD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDPD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDPD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDPD4 Gene

Proteins for GDPD4 Gene

  • Protein details for GDPD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycerophosphodiester phosphodiesterase domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q7Z5B0

    Protein attributes for GDPD4 Gene

    623 amino acids
    Molecular mass:
    71996 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GDPD4 Gene


neXtProt entry for GDPD4 Gene

Post-translational modifications for GDPD4 Gene

  • Glycosylation at Asn308 and Asn397
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GDPD4 Gene

Domains & Families for GDPD4 Gene

Gene Families for GDPD4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GDPD4 Gene

  • Glycerophosphoryl diester phosphodiesterase

Suggested Antigen Peptide Sequences for GDPD4 Gene

GenScript: Design optimal peptide antigens:
  • UgpQ (GDPD4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycerophosphoryl diester phosphodiesterase family.
  • Belongs to the glycerophosphoryl diester phosphodiesterase family.
genes like me logo Genes that share domains with GDPD4: view

Function for GDPD4 Gene

Enzyme Numbers (IUBMB) for GDPD4 Gene

Phenotypes From GWAS Catalog for GDPD4 Gene

Gene Ontology (GO) - Molecular Function for GDPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GDPD4: view
genes like me logo Genes that share phenotypes with GDPD4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GDPD4

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GDPD4 Gene

Localization for GDPD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDPD4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GDPD4 gene
Compartment Confidence
plasma membrane 3
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GDPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GDPD4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GDPD4 Gene

Pathways & Interactions for GDPD4 Gene

PathCards logo

SuperPathways for GDPD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GDPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with GDPD4: view

No data available for Pathways by source and SIGNOR curated interactions for GDPD4 Gene

Drugs & Compounds for GDPD4 Gene

No Compound Related Data Available

Transcripts for GDPD4 Gene

mRNA/cDNA for GDPD4 Gene

3 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GDPD4

Alternative Splicing Database (ASD) splice patterns (SP) for GDPD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - -
SP2: -

Relevant External Links for GDPD4 Gene

GeneLoc Exon Structure for

Expression for GDPD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GDPD4 Gene

mRNA differential expression in normal tissues according to GTEx for GDPD4 Gene

This gene is overexpressed in Testis (x32.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GDPD4 Gene

Protein tissue co-expression partners for GDPD4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GDPD4

SOURCE GeneReport for Unigene cluster for GDPD4 Gene:

genes like me logo Genes that share expression patterns with GDPD4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GDPD4 Gene

Orthologs for GDPD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GDPD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GDPD4 31 30
  • 96.6 (n)
(Canis familiaris)
Mammalia GDPD4 31 30
  • 81.18 (n)
(Mus musculus)
Mammalia Gdpd4 17 31 30
  • 76.79 (n)
(Rattus norvegicus)
Mammalia Gdpd4 30
  • 76.34 (n)
(Bos Taurus)
Mammalia LOC524642 30
  • 75.68 (n)
-- 31
  • 62 (a)
-- 31
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia GDPD4 31
  • 33 (a)
(Monodelphis domestica)
Mammalia GDPD4 31
  • 31 (a)
(Gallus gallus)
Aves GDPD4 31 30
  • 59.44 (n)
(Anolis carolinensis)
Reptilia GDPD4 31
  • 38 (a)
(Danio rerio)
Actinopterygii GDPD4 (1 of 3) 31
  • 38 (a)
gdpd4a 31
  • 38 (a)
GDPD4 (3 of 3) 31
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
Species where no ortholog for GDPD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GDPD4 Gene

Gene Tree for GDPD4 (if available)
Gene Tree for GDPD4 (if available)
Evolutionary constrained regions (ECRs) for GDPD4: view image

Paralogs for GDPD4 Gene

Paralogs for GDPD4 Gene

(2) SIMAP similar genes for GDPD4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GDPD4: view

Variants for GDPD4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GDPD4 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11237145 - p.Ile390Val
rs11237146 - p.His383Tyr
rs2729772 - p.Lys220Arg
VAR_064764 - p.Asn396Lys

Additional dbSNP identifiers (rs#s) for GDPD4 Gene

Structural Variations from Database of Genomic Variants (DGV) for GDPD4 Gene

Variant ID Type Subtype PubMed ID
dgv1231n100 CNV gain 25217958
esv2762917 CNV loss 21179565
esv3305947 CNV mobile element insertion 20981092
esv3309251 CNV mobile element insertion 20981092
esv3338332 CNV insertion 20981092
esv3339902 CNV insertion 20981092
esv3378982 CNV insertion 20981092
esv3626879 CNV gain 21293372
esv3626880 CNV loss 21293372
nsv1049476 CNV gain 25217958
nsv509434 CNV insertion 20534489

Variation tolerance for GDPD4 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.39; 97.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GDPD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDPD4 Gene

Disorders for GDPD4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GDPD4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
salivary gland disease
  • non-neoplastic salivary gland disease
- elite association - COSMIC cancer census association via MalaCards
Search GDPD4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GDPD4

genes like me logo Genes that share disorders with GDPD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GDPD4 Gene

Publications for GDPD4 Gene

  1. Exome sequencing in Thai patients with familial obesity. (PMID: 27421018) Kaewsutthi S … Tungtrongchitr R (Genetics and molecular research : GMR 2016) 3 54
  2. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I … Futreal PA (Nature 2011) 4 54
  3. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PMID: 17903298) Meigs JB … Dupuis J (BMC medical genetics 2007) 41 54
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54

Products for GDPD4 Gene

Sources for GDPD4 Gene