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GDPD3 (Glycerophosphodiester Phosphodiesterase Domain Containing 3) is a Protein Coding gene. Diseases associated with GDPD3 include Myopathy, Distal, 3 and Schizophrenia 3. Among its related pathways are Acyl chain remodelling of PE and PI Metabolism. Gene Ontology (GO) annotations related to this gene include phosphoric diester hydrolase activity and glycerophosphodiester phosphodiesterase activity. An important paralog of this gene is GDPD1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004622 | lysophospholipase activity | IBA | 21873635 |
GO:0008081 | phosphoric diester hydrolase activity | IBA | 21873635 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | IEA,ISS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PI Metabolism |
.63
|
|
2 | Metabolism |
.40
|
|
3 | Acyl chain remodelling of PE | ||
4 | Glycerophospholipid biosynthesis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006644 | phospholipid metabolic process | IEA,IBA | 21873635 |
GO:0034638 | phosphatidylcholine catabolic process | IEA | -- |
GO:0046475 | glycerophospholipid catabolic process | IBA | 21873635 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GDPD3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GDPD3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GDPD3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gdpd3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gdpd3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | GDPD3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GDPD3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100125107 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | gdpd3b 30 31 |
|
OneToMany | |
gdpd3a 31 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs8061772 | Benign: not specified | 30,108,204(-) | C/A | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2758642 | CNV | gain | 17122850 |
nsv1131237 | CNV | deletion | 24896259 |
nsv1160384 | CNV | duplication | 26073780 |
nsv833187 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
myopathy, distal, 3 |
|
|
schizophrenia 3 |
|
|