Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the glycerophosphodiester phosphodiesterase family of enzymes that catalyze the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol. The encoded protein is localized to the cytoplasm and concentrates near the perinuclear region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
GDPD1 (Glycerophosphodiester Phosphodiesterase Domain Containing 1) is a Protein Coding gene. Among its related pathways are Acyl chain remodelling of PE and PI Metabolism. Gene Ontology (GO) annotations related to this gene include phosphoric diester hydrolase activity and glycerophosphodiester phosphodiesterase activity. An important paralog of this gene is GDPD3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004622 | lysophospholipase activity | IMP | 25596343 |
GO:0008081 | phosphoric diester hydrolase activity | IEA,IBA | 21873635 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA,HDA | 19946888 |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0048471 | perinuclear region of cytoplasm | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PI Metabolism |
.63
|
|
2 | Metabolism |
.40
|
|
3 | Acyl chain remodelling of PE | ||
4 | Glycerophospholipid biosynthesis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006644 | phospholipid metabolic process | IBA | 21873635 |
GO:0046475 | glycerophospholipid catabolic process | IBA | 21873635 |
GO:0070291 | N-acylethanolamine metabolic process | IMP | 25596343 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GDPD1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GDPD1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GDPD1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gdpd1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | GDPD1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gdpd1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GDPD1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GDPD1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GDPD1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gdpd1 30 |
|
||
Str.20315 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | gdpd1 30 31 |
|
OneToOne | |
wufk14g09 30 |
|
||||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PGC1 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3270n100 | CNV | gain | 25217958 |
dgv3271n100 | CNV | gain | 25217958 |
esv2758699 | CNV | gain | 17122850 |
esv3573764 | CNV | gain | 25503493 |
esv3640903 | CNV | loss | 21293372 |
nsv1057152 | CNV | gain | 25217958 |
nsv1062736 | CNV | gain | 25217958 |
nsv1065063 | CNV | gain | 25217958 |
nsv1065442 | CNV | gain | 25217958 |
nsv1109093 | CNV | deletion | 24896259 |
nsv1138561 | CNV | deletion | 24896259 |
nsv575802 | CNV | loss | 21841781 |
nsv575803 | CNV | gain | 21841781 |
nsv575804 | CNV | gain | 21841781 |
nsv828070 | CNV | loss | 20364138 |
nsv833500 | CNV | loss | 17160897 |
No disorders were found for GDPD1 Gene.