This gene encodes a member of the glycerophosphodiester phosphodiesterase family of enzymes that catalyze the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol. The encoded protein is localized to the cytoplasm and concentrates near the perinuclear region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] See more...
Aliases for GDPD1 Gene
Aliases for GDPD1 Gene
External Ids for GDPD1 Gene
- HGNC: 20883
- Entrez Gene: 284161
- Ensembl: ENSG00000153982
- OMIM: 616317
- UniProtKB: Q8N9F7
Previous GeneCards Identifiers for GDPD1 Gene
- GC00U909461
- GC17P054653
- GC17P057297
- GC17P052657
Summaries for GDPD1 Gene
-
This gene encodes a member of the glycerophosphodiester phosphodiesterase family of enzymes that catalyze the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol. The encoded protein is localized to the cytoplasm and concentrates near the perinuclear region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
GeneCards Summary for GDPD1 Gene
GDPD1 (Glycerophosphodiester Phosphodiesterase Domain Containing 1) is a Protein Coding gene. Among its related pathways are PI Metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include phosphoric diester hydrolase activity and glycerophosphodiester phosphodiesterase activity. An important paralog of this gene is GDPD3.
UniProtKB/Swiss-Prot Summary for GDPD1 Gene
-
Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine.
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GDPD1 Gene
Genomics for GDPD1 Gene
GeneHancer (GH) Regulatory Elements for GDPD1 Gene
Promoters and enhancers for GDPD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GDPD1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GDPD1 gene promoter:
-
- AP-2gamma
- ATF6
- Bach1
- HNF-1
- HNF-1A
- HOXA9B
- LyF-1
- Nkx2-2
- RSRFC4
- STAT3
Genomic Locations for GDPD1 Gene
Genomic Locations for GDPD1 Gene
- chr17:59,220,467-59,275,970
- (GRCh38/hg38)
- Size:
- 55,504 bases
- Orientation:
- Plus strand
- chr17:57,297,828-57,353,331
- (GRCh37/hg19)
- Size:
- 55,504 bases
- Orientation:
- Plus strand
Genomic View for GDPD1 Gene
Genes around GDPD1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q22 by HGNC
- 17q22 by Entrez Gene
- 17q22 by Ensembl
GDPD1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GDPD1 Gene
Proteins for GDPD1 Gene
-
Protein details for GDPD1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N9F7-GDPD1_HUMAN
- Recommended name:
- Lysophospholipase D GDPD1
- Protein Accession:
- Q8N9F7
- A8W735
- Q56VR1
- Q8N4E3
Protein attributes for GDPD1 Gene
- Size:
- 314 amino acids
- Molecular mass:
- 36167 Da
- Quaternary structure:
- No Data Available
Protein Expression for GDPD1 Gene
Post-translational modifications for GDPD1 Gene
Other Protein References for GDPD1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GDPD1
- Invitrogen Antibodies for GDPD1 (AFLGC-GDPD1)
Protein Products
-
OriGene Purified Proteins for GDPD1
- Search Origene for MassSpec and Protein Over-expression Lysates for GDPD1
- Origene Custom Protein Services for GDPD1
- antibodies-online: Show 6 available GDPD1 Proteins ranked by validation data
- Compare Top GDPD1 Proteins
-
Quality Products:
No data available for DME Specific Peptides for GDPD1 Gene
Domains & Families for GDPD1 Gene
Gene Families for GDPD1 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for GDPD1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GDPD1 Gene
- GenScript: Design optimal peptide antigens:
-
- Glycerophosphodiester phosphodiesterase 4 (GDPD1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8N9F7UniProtKB/Swiss-Prot:
GDPD1_HUMAN :- Belongs to the glycerophosphoryl diester phosphodiesterase family.
- Family:
-
- Belongs to the glycerophosphoryl diester phosphodiesterase family.
Function for GDPD1 Gene
Molecular function for GDPD1 Gene
- UniProtKB/Swiss-Prot Function:
- Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+); Xref=Rhea:RHEA:15965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57603, ChEBI:CHEBI:58014, ChEBI:CHEBI:76168; EC=3.1.4.39; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphate + H(+) + N-acylethanolamine; Xref=Rhea:RHEA:53164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:52640, ChEBI:CHEBI:57970, ChEBI:CHEBI:85216; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+); Xref=Rhea:RHEA:39003, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57603, ChEBI:CHEBI:57970, ChEBI:CHEBI:64381; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H(+) + N-acylethanolamine; Xref=Rhea:RHEA:53176, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:52640, ChEBI:CHEBI:77283, ChEBI:CHEBI:140403; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:38995, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57970, ChEBI:CHEBI:58168; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:39927, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30909, ChEBI:CHEBI:58014; Evidence=. ;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:38975, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57518, ChEBI:CHEBI:72998; Evidence=. ;.
Enzyme Numbers (IUBMB) for GDPD1 Gene
Phenotypes From GWAS Catalog for GDPD1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004622 | lysophospholipase activity | IMP | 25596343 |
| GO:0008081 | phosphoric diester hydrolase activity | IEA,IBA | 21873635 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity | IEA | -- |
Phenotypes for GDPD1 Gene
Animal Model Products
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CRISPR Products
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- * GDPD1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for GDPD1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GDPD1
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- Overview of 144 available GDPD1 gene related products
-
Recommended
-
Santa Cruz Biotechnology (SCBT) CRISPR for GDPD1
miRNA for GDPD1 Gene
- miRTarBase miRNAs that target GDPD1
-
- hsa-mir-335-5p (MIRT016859)
- hsa-mir-3149 (MIRT518552)
- hsa-mir-4776-3p (MIRT518553)
- hsa-mir-6855-5p (MIRT518554)
- hsa-mir-3170 (MIRT518555)
- hsa-mir-4659b-5p (MIRT518556)
- hsa-mir-4659a-5p (MIRT518557)
- hsa-mir-5590-5p (MIRT518558)
- hsa-mir-19b-2-5p (MIRT518559)
- hsa-mir-19b-1-5p (MIRT518560)
- hsa-mir-19a-5p (MIRT518561)
- hsa-mir-6832-5p (MIRT518562)
- hsa-mir-4451 (MIRT518563)
- hsa-mir-379-5p (MIRT518564)
- hsa-mir-3529-5p (MIRT518565)
- hsa-mir-4650-3p (MIRT518566)
- hsa-mir-193b-5p (MIRT518567)
- hsa-mir-1273f (MIRT518568)
- hsa-mir-6890-5p (MIRT518569)
- hsa-mir-3658 (MIRT531333)
- hsa-mir-4477a (MIRT531334)
- hsa-mir-3653-3p (MIRT531335)
- hsa-mir-4307 (MIRT531336)
- hsa-mir-8084 (MIRT531337)
- hsa-mir-3613-3p (MIRT611713)
- hsa-mir-548c-3p (MIRT611714)
- hsa-mir-4666a-5p (MIRT615916)
- hsa-mir-6778-3p (MIRT668143)
- hsa-mir-4707-3p (MIRT668144)
- hsa-mir-4454 (MIRT668145)
- hsa-mir-2116-3p (MIRT668146)
- hsa-mir-7107-5p (MIRT668147)
- hsa-mir-1234-3p (MIRT668148)
- hsa-mir-153-5p (MIRT783901)
miRNA Products
Inhibitory RNA Products
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- * GDPD1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * GDPD1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG204495
- MR204495
- MR204495L3
- MR204495L3V
- MR204495L4
- MR204495L4V
- RC223431
- RC223431L3
- RC223431L3V
- RC223431L4
- RC223431L4V
- RC228223
- RC228223L3
- RC228223L3V
- RC228223L4
- RC228223L4V
- RC228806
- RC228806L3
- RC228806L3V
- RC228806L4
- RC228806L4V
- RG223431
- RG228223
- RG228806
- RR209828
- RR209828L1
- RR209828L1V
- RR209828L2
- RR209828L2V
- RR209828L3
- RR209828L3V
- RR209828L4
- RR209828L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GDPD1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GDPD1
- genomics-online: cdna clones - Search for available GDPD1 CDNA products
- Overview of 144 available GDPD1 gene related products
-
Recommended
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- Overview of 144 available GDPD1 gene related products
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Recommended
Cell Line Products
-
Horizon Cell Lines for GDPD1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GDPD1 Gene
Localization for GDPD1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GDPD1 Gene
- Cytoplasm. Membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Concentrated at the perinuclear region and the cell periphery (PubMed:18991142). {ECO:0000269 PubMed:18991142}.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| cytosol | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA,HDA | 19946888 |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0048471 | perinuclear region of cytoplasm | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GDPD1 Gene
Pathways & Interactions for GDPD1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PI Metabolism |
.63
|
|
| 2 | Metabolism |
.40
|
|
| 3 | Acyl chain remodelling of PE | ||
| 4 | Glycerophospholipid biosynthesis | ||
Pathways by source for GDPD1 Gene
5 Reactome pathways for GDPD1 Gene
1 KEGG pathway for GDPD1 Gene
Interacting Proteins for GDPD1 Gene
GPS-Prot Interaction Network for GDPD1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006644 | phospholipid metabolic process | IBA | 21873635 |
| GO:0046475 | glycerophospholipid catabolic process | IBA | 21873635 |
| GO:0070291 | N-acylethanolamine metabolic process | IMP | 25596343 |
No data available for SIGNOR curated interactions for GDPD1 Gene
Transcripts for GDPD1 Gene
mRNA/cDNA for GDPD1 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (34) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000578026 934 bps (ENST00000578026.5)
- ENST00000284116 3241 bps (ENST00000284116.8)
- ENST00000581140 1265 bps (ENST00000581140.5)
- ENST00000579020 834 bps (ENST00000579020.5)
- ENST00000581276 1055 bps (ENST00000581276.5)
CRISPR Products
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-
OriGene CRISPR knockouts for GDPD1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GDPD1
- genomics-online: gRNA clones - Search for available GDPD1 gRNA products
- Overview of 144 available GDPD1 gene related products
-
Recommended
-
Santa Cruz Biotechnology (SCBT) CRISPR for GDPD1
miRNA Products
Inhibitory RNA Products
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- Overview of 144 available GDPD1 gene related products
-
Recommended
Clone Products
- Applied Biological Materials (abm): Clones for GDPD1 - Select products 50% OFF >
- * GDPD1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * GDPD1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG204495
- MR204495
- MR204495L3
- MR204495L3V
- MR204495L4
- MR204495L4V
- RC223431
- RC223431L3
- RC223431L3V
- RC223431L4
- RC223431L4V
- RC228223
- RC228223L3
- RC228223L3V
- RC228223L4
- RC228223L4V
- RC228806
- RC228806L3
- RC228806L3V
- RC228806L4
- RC228806L4V
- RG223431
- RG228223
- RG228806
- RR209828
- RR209828L1
- RR209828L1V
- RR209828L2
- RR209828L2V
- RR209828L3
- RR209828L3V
- RR209828L4
- RR209828L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GDPD1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GDPD1
- genomics-online: cdna clones - Search for available GDPD1 CDNA products
- Overview of 144 available GDPD1 gene related products
-
Recommended
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- Overview of 144 available GDPD1 gene related products
-
Recommended
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: |
Expression for GDPD1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Gut Tube (Gastrointestinal Tract)
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for GDPD1 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.9).
This gene is overexpressed in Adrenal (23.0), Fetal Brain (13.2), and Placenta (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GDPD1 Gene
NURSA nuclear receptor signaling pathways regulating expression of GDPD1 Gene:
GDPD1SOURCE GeneReport for Unigene cluster for GDPD1 Gene:
Hs.631744mRNA Expression by UniProt/SwissProt for GDPD1 Gene:
Q8N9F7-GDPD1_HUMAN
Tissue specificity:
Widely expressed with high expression level in testis.
Evidence on tissue expression from TISSUES for GDPD1 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for GDPD1
-
OriGene qPCR primer pairs and template standards for GDPD1
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Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GDPD1 Gene
Orthologs for GDPD1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GDPD1 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GDPD1 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GDPD1 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Gdpd1 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GDPD1 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gdpd1 17 33 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GDPD1 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GDPD1 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GDPD1 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gdpd1 32 |
|
||
| Str.20315 32 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | gdpd1 33 32 |
|
OneToOne | |
| wufk14g09 32 |
|
||||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PGC1 35 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for GDPD1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for GDPD1 Gene
- ENSEMBL:
- Gene Tree for GDPD1 (if available)
- TreeFam:
- Gene Tree for GDPD1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GDPD1: view image
Paralogs for GDPD1 Gene
Variants for GDPD1 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000053340 | -- | 59,270,528(+) | G/A/T | intron_variant | |
| rs1000068923 | -- | 59,223,210(+) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000093152 | -- | 59,255,550(+) | T/C | intron_variant | |
| rs1000122213 | -- | 59,272,374(+) | C/G | intron_variant | |
| rs1000177400 | -- | 59,230,468(+) | C/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3270n100 | CNV | gain | 25217958 |
| dgv3271n100 | CNV | gain | 25217958 |
| esv2758699 | CNV | gain | 17122850 |
| esv3573764 | CNV | gain | 25503493 |
| esv3640903 | CNV | loss | 21293372 |
| nsv1057152 | CNV | gain | 25217958 |
| nsv1062736 | CNV | gain | 25217958 |
| nsv1065063 | CNV | gain | 25217958 |
| nsv1065442 | CNV | gain | 25217958 |
| nsv1109093 | CNV | deletion | 24896259 |
| nsv1138561 | CNV | deletion | 24896259 |
| nsv575802 | CNV | loss | 21841781 |
| nsv575803 | CNV | gain | 21841781 |
| nsv575804 | CNV | gain | 21841781 |
| nsv828070 | CNV | loss | 20364138 |
| nsv833500 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
22.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.60;
12.88% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GDPD1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GDPD1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDPD1 Gene
Disorders for GDPD1 Gene
Additional Disease Information for GDPD1
No disorders were found for GDPD1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GDPD1 Gene
Publications for GDPD1 Gene
- Isolation, characterization and molecular 3D model of human GDE4, a novel membrane protein containing glycerophosphodiester phosphodiesterase domain. (PMID: 18991142) Chang PA … Wu YJ (Molecular membrane biology 2008) 3 4 23 56
- Mammalian glycerophosphodiester phosphodiesterases. (PMID: 17690467) Yanaka N (Bioscience, biotechnology, and biochemistry 2007) 3 23 56
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
- A novel splice variant of human gene GDPD1 is mainly expressed in human ovary and small intestine. (PMID: 14612981) Wu M … Mao Y (International journal of molecular medicine 2003) 2 3 56
ExternalLinks
Products for GDPD1 Gene
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Sources for GDPD1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (13) UniProtKB/TrEMBL
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- (28) ASD
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- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
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- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
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- (118) NCBI Bookshelf
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