Aliases for GDI2 Gene
External Ids for GDI2 Gene
Previous GeneCards Identifiers for GDI2 Gene
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for GDI2 Gene
GDI2 (GDP Dissociation Inhibitor 2) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include small GTPase binding. An important paralog of this gene is GDI1.
UniProtKB/Swiss-Prot for GDI2 Gene
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.