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Aliases for GDF5OS Gene

Aliases for GDF5OS Gene

  • Growth Differentiation Factor 5 Opposite Strand 2 3 5
  • Growth/Differentiation Factor 5 Opposite Strand Transcript Protein 4

External Ids for GDF5OS Gene

Previous GeneCards Identifiers for GDF5OS Gene

  • GC20P033486
  • GC20P034020
  • GC20P030798

Summaries for GDF5OS Gene

GeneCards Summary for GDF5OS Gene

GDF5OS (Growth Differentiation Factor 5 Opposite Strand) is a Protein Coding gene.

Additional gene information for GDF5OS Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDF5OS Gene

Genomics for GDF5OS Gene

GeneHancer (GH) Regulatory Elements for GDF5OS Gene

Promoters and enhancers for GDF5OS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I035434 Enhancer 0.3 ENCODE 550.8 +1.7 1654 0.8 NFIC GC20M035435 GC20M035436 PIR39367 GDF5OS UQCC1 MMP24OS EDEM2 MIR1289-1 GDF5
GH20I035431 Enhancer 0.2 FANTOM5 550.8 -1.8 -1789 0.3 GDF5OS EIF6 MYH7B UQCC1
GH20I035324 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.1 -105.4 -105429 5.3 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 FOS DEK SP5 UQCC1 FAM83C EIF6 FAM83C-AS1 MMP24OS EDEM2 GDF5OS MMP24 CPNE1 FER1L4
GH20I035465 Enhancer 1 ENCODE 11 +34.0 34043 3.2 PKNOX1 FOXA2 ARID4B FEZF1 DMAP1 ZNF48 SLC30A9 SP5 MXD4 TSHZ1 RPL36P4 ENSG00000242507 C20orf173 LOC102725201 GDF5OS NFS1 ROMO1 CEP250
GH20I035337 Enhancer 0.8 ENCODE dbSUPER 11.3 -93.6 -93615 3.2 CEBPB ZNF121 ZFHX2 POLR2A ZNF341 GLIS1 HMBOX1 WT1 EGR2 UQCC1 MMP24OS FAM83C EIF6 FAM83C-AS1 GDF5OS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GDF5OS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GDF5OS gene promoter:

Genomic Locations for GDF5OS Gene

Genomic Locations for GDF5OS Gene
2,422 bases
Plus strand

Genomic View for GDF5OS Gene

Genes around GDF5OS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDF5OS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDF5OS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for GDF5OS Gene

Proteins for GDF5OS Gene

  • Protein details for GDF5OS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein GDF5OS, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6PVI8

    Protein attributes for GDF5OS Gene

    250 amino acids
    Molecular mass:
    28211 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GDF5OS Gene

Post-translational modifications for GDF5OS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GDF5OS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GDF5OS Gene

Domains & Families for GDF5OS Gene

Gene Families for GDF5OS Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GDF5OS Gene


Suggested Antigen Peptide Sequences for GDF5OS Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GDF5OS: view

No data available for UniProtKB/Swiss-Prot for GDF5OS Gene

Function for GDF5OS Gene

Phenotypes From GWAS Catalog for GDF5OS Gene

miRNA for GDF5OS Gene

miRTarBase miRNAs that target GDF5OS

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GDF5OS Gene

Localization for GDF5OS Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDF5OS Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GDF5OS gene
Compartment Confidence
mitochondrion 4
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GDF5OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with GDF5OS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GDF5OS Gene

Pathways & Interactions for GDF5OS Gene

SuperPathways for GDF5OS Gene

No Data Available

Interacting Proteins for GDF5OS Gene

Gene Ontology (GO) - Biological Process for GDF5OS Gene


No data available for Pathways by source and SIGNOR curated interactions for GDF5OS Gene

Drugs & Compounds for GDF5OS Gene

No Compound Related Data Available

Transcripts for GDF5OS Gene

mRNA/cDNA for GDF5OS Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GDF5OS Gene

Growth differentiation factor 5 opposite strand:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GDF5OS Gene

No ASD Table

Relevant External Links for GDF5OS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GDF5OS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GDF5OS Gene

NURSA nuclear receptor signaling pathways regulating expression of GDF5OS Gene:


SOURCE GeneReport for Unigene cluster for GDF5OS Gene:

genes like me logo Genes that share expression patterns with GDF5OS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GDF5OS Gene

Orthologs for GDF5OS Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for GDF5OS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GDF5OS 34
  • 99 (a)
(Mus musculus)
Mammalia Gm15557 34
  • 88 (a)
Species where no ortholog for GDF5OS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GDF5OS Gene

Gene Tree for GDF5OS (if available)
Gene Tree for GDF5OS (if available)

Paralogs for GDF5OS Gene

No data available for Paralogs for GDF5OS Gene

Variants for GDF5OS Gene

Variation tolerance for GDF5OS Gene

Gene Damage Index Score: 9.74; 89.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GDF5OS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for GDF5OS Gene

Disorders for GDF5OS Gene

Additional Disease Information for GDF5OS

No disorders were found for GDF5OS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GDF5OS Gene

Publications for GDF5OS Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 4 58

Products for GDF5OS Gene

Sources for GDF5OS Gene

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