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Aliases for GDF15 Gene

Aliases for GDF15 Gene

  • Growth Differentiation Factor 15 2 3 5
  • Prostate Differentiation Factor 2 3 4
  • Non-Steroidal Anti-Inflammatory Drug-Activated Gene-1 2 3
  • Placental Bone Morphogenetic Protein 3 4
  • Macrophage Inhibitory Cytokine 1 3 4
  • NSAID-Activated Gene 1 Protein 3 4
  • NSAID-Regulated Gene 1 Protein 3 4
  • Placental TGF-Beta 3 4
  • GDF-15 3 4
  • MIC-1 3 4
  • NAG-1 3 4
  • NRG-1 3 4
  • PTGFB 3 4
  • MIC1 3 4
  • PLAB 3 4
  • PDF 3 4
  • NSAID (Nonsteroidal Anti-Inflammatory Drug)-Activated Protein 1 3
  • Growth/Differentiation Factor 15 3
  • Macrophage Inhibitory Cytokine-1 2
  • PTGF-Beta 3

External Ids for GDF15 Gene

Previous GeneCards Identifiers for GDF15 Gene

  • GC00U914343
  • GC19P018318
  • GC19P018358
  • GC19P018496
  • GC19P018613
  • GC19P018542
  • GC19P018556
  • GC19P018720
  • GC19P019032
  • GC19P019349
  • GC19P019680

Summaries for GDF15 Gene

Entrez Gene Summary for GDF15 Gene

  • This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]

GeneCards Summary for GDF15 Gene

GDF15 (Growth Differentiation Factor 15) is a Protein Coding gene. Diseases associated with GDF15 include Pulmonary Systemic Sclerosis and Oral Cavity Cancer. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is GDF1.

UniProtKB/Swiss-Prot for GDF15 Gene

  • Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the emergency circuit that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).

Gene Wiki entry for GDF15 Gene

Additional gene information for GDF15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDF15 Gene

Genomics for GDF15 Gene

GeneHancer (GH) Regulatory Elements for GDF15 Gene

Promoters and enhancers for GDF15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J018372 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 662.3 +6.4 6369 18 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 GDF15 NR2C2AP ENSG00000268030 IQCN UPF1 ENSG00000268938 MAU2 MEF2B ENSG00000269191 COLGALT1
GH19J018392 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 6.9 +21.2 21215 7.9 FOXA2 ARNT ARID4B SIN3A ZNF48 YY1 ZNF143 FOS ATF7 RUNX3 LRRC25 IFI30 IQCN LSM4 PGPEP1 GDF15 ELL SSBP4 KCNN1 ARRDC2
GH19J018368 Enhancer 1.1 Ensembl ENCODE dbSUPER 8.8 -5.6 -5592 2.2 BCOR TFAP4 RARA ZNF121 TCF12 POLR2A NCOR1 CBFA2T2 NR2F6 L3MBTL2 GDF15 KCNN1 PGPEP1
GH19J018391 Enhancer 0.8 ENCODE 6.7 +15.5 15485 0.2 CHAMP1 POLR2B E2F8 PAF1 SMAD5 ZEB2 TGIF2 SSRP1 ETV4 IKZF1 GC19P020605 MAU2 IQCN GDF15 PGPEP1 MIR3189
GH19J018736 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 1.2 +365.6 365640 7.7 ATF1 FOXA2 ARID4B DMAP1 ZNF48 SLC30A9 TCF12 GATA2 ZFP91 ZNF263 ATP13A1 ENSG00000268938 ENSG00000269191 UPF1 ENSG00000268030 IQCN NR2C2AP MAU2 ZNF14 MEF2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GDF15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GDF15 gene promoter:
  • STAT3
  • c-Jun
  • ATF-2
  • AP-1
  • C/EBPbeta
  • PPAR-gamma2
  • PPAR-gamma1

Genomic Locations for GDF15 Gene

Genomic Locations for GDF15 Gene
chr19:18,374,731-18,389,176
(GRCh38/hg38)
Size:
14,446 bases
Orientation:
Plus strand
chr19:18,485,541-18,499,986
(GRCh37/hg19)
Size:
14,446 bases
Orientation:
Plus strand

Genomic View for GDF15 Gene

Genes around GDF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDF15 Gene

Proteins for GDF15 Gene

  • Protein details for GDF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99988-GDF15_HUMAN
    Recommended name:
    Growth/differentiation factor 15
    Protein Accession:
    Q99988
    Secondary Accessions:
    • O14629
    • P78360
    • Q9BWA0
    • Q9NRT0

    Protein attributes for GDF15 Gene

    Size:
    308 amino acids
    Molecular mass:
    34140 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (PubMed:29046435). Interacts with GFRAL; ligand of GFRAL which mediates GDF15 internalization and cellular signaling through interaction with RET (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099).

    Three dimensional structures from OCA and Proteopedia for GDF15 Gene

neXtProt entry for GDF15 Gene

Post-translational modifications for GDF15 Gene

  • Glycosylation at isoforms=70 and isoforms=44
  • Modification sites at PhosphoSitePlus

Other Protein References for GDF15 Gene

Antibody Products

  • Abcam antibodies for GDF15

No data available for DME Specific Peptides for GDF15 Gene

Domains & Families for GDF15 Gene

Gene Families for GDF15 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for GDF15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99988

UniProtKB/Swiss-Prot:

GDF15_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with GDF15: view

Function for GDF15 Gene

Molecular function for GDF15 Gene

UniProtKB/Swiss-Prot Function:
Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the emergency circuit that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).
UniProtKB/Swiss-Prot Induction:
Expression is up-regulated by obesity.

Phenotypes From GWAS Catalog for GDF15 Gene

Gene Ontology (GO) - Molecular Function for GDF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005515 protein binding IPI 19060904
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with GDF15: view
genes like me logo Genes that share phenotypes with GDF15: view

Animal Models for GDF15 Gene

MGI Knock Outs for GDF15:

Animal Model Products

  • Taconic Biosciences Mouse Models for GDF15

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GDF15 Gene

Localization for GDF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDF15 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GDF15 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GDF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 9326641
GO:0005615 extracellular space IDA,IEA 25893289
GO:0005634 nucleus IDA 25893289
GO:0005737 cytoplasm IDA 25893289
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with GDF15: view

Pathways & Interactions for GDF15 Gene

genes like me logo Genes that share pathways with GDF15: view

Pathways by source for GDF15 Gene

Gene Ontology (GO) - Biological Process for GDF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9326641
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 9348093
GO:0007267 cell-cell signaling TAS 9326641
GO:0010469 regulation of signaling receptor activity IEA --
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA --
genes like me logo Genes that share ontologies with GDF15: view

No data available for SIGNOR curated interactions for GDF15 Gene

Drugs & Compounds for GDF15 Gene

(9) Drugs for GDF15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(9) Additional Compounds for GDF15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GDF15: view

Transcripts for GDF15 Gene

mRNA/cDNA for GDF15 Gene

Unigene Clusters for GDF15 Gene

Growth differentiation factor 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GDF15 Gene

No ASD Table

Relevant External Links for GDF15 Gene

GeneLoc Exon Structure for
GDF15
ECgene alternative splicing isoforms for
GDF15

Expression for GDF15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GDF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GDF15 Gene

This gene is overexpressed in Bladder (x7.8), Kidney - Cortex (x6.3), Prostate (x5.0), and Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for GDF15 Gene

This gene is overexpressed in Amniocyte (24.2), Placenta (15.9), Lung (13.7), and Bone marrow mesenchymal stem cell (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GDF15 Gene



NURSA nuclear receptor signaling pathways regulating expression of GDF15 Gene:

GDF15

SOURCE GeneReport for Unigene cluster for GDF15 Gene:

Hs.616962

mRNA Expression by UniProt/SwissProt for GDF15 Gene:

Q99988-GDF15_HUMAN
Tissue specificity: Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney (PubMed:9348093). Detected in plasma (at protein level) (PubMed:28572090, PubMed:29046435).

Evidence on tissue expression from TISSUES for GDF15 Gene

  • Muscle(4.6)
  • Skin(4.6)
  • Lung(4.3)
  • Intestine(4.1)
  • Kidney(3.9)
  • Liver(3.8)
  • Pancreas(2.9)
  • Blood(2.4)
  • Heart(2.4)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with GDF15: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GDF15 Gene

Orthologs for GDF15 Gene

This gene was present in the common ancestor of animals.

Orthologs for GDF15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GDF15 34 33
  • 98.05 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GDF15 34 33
  • 74.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GDF15 34 33
  • 74.34 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gdf15 33
  • 68.86 (n)
mouse
(Mus musculus)
Mammalia Gdf15 16 34 33
  • 68.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GDF15 34
  • 34 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GDF15 34
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ndr1 34
  • 13 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea daf-7 34
  • 14 (a)
OneToOne
Species where no ortholog for GDF15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GDF15 Gene

ENSEMBL:
Gene Tree for GDF15 (if available)
TreeFam:
Gene Tree for GDF15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GDF15: view image

Paralogs for GDF15 Gene

genes like me logo Genes that share paralogs with GDF15: view

Variants for GDF15 Gene

Sequence variations from dbSNP and Humsavar for GDF15 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000290705 -- 18,386,761(+) C/G intron_variant
rs1000641221 -- 18,387,158(+) A/G intron_variant
rs1002465534 -- 18,384,767(+) T/C upstream_transcript_variant
rs1003080580 -- 18,385,151(+) T/C upstream_transcript_variant
rs1004319159 -- 18,384,576(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GDF15 Gene

Variant ID Type Subtype PubMed ID
nsv2430 CNV deletion 18451855
nsv952420 CNV deletion 24416366

Variation tolerance for GDF15 Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.20; 90.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GDF15 Gene

Human Gene Mutation Database (HGMD)
GDF15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GDF15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDF15 Gene

Disorders for GDF15 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GDF15 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pulmonary systemic sclerosis
  • lung disease with systemic sclerosis
oral cavity cancer
  • malignant neoplasm of anterior portion of floor of mouth
heart disease
  • congestive heart failure
colorectal cancer
  • crc
prostate cancer
  • prostate cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search GDF15 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GDF15_HUMAN
  • Note=Plasma levels are increased in children with concomitant heart disease and failure to thrive but not in children with heart disease and normal body weight. {ECO:0000269 PubMed:28572090}.

Additional Disease Information for GDF15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GDF15: view

No data available for Genatlas for GDF15 Gene

Publications for GDF15 Gene

  1. Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. (PMID: 11895857) Baek SJ … Eling TE (Carcinogenesis 2002) 2 3 22 58
  2. Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. (PMID: 11259636) Baek SJ … Eling TE (Molecular pharmacology 2001) 3 4 22 58
  3. Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family. (PMID: 9593718) Paralkar VM … Thompson DD (The Journal of biological chemistry 1998) 2 3 4 58
  4. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. (PMID: 9326641) Bootcov MR … Breit SN (Proceedings of the National Academy of Sciences of the United States of America 1997) 3 4 22 58
  5. PLAB, a novel placental bone morphogenetic protein. (PMID: 9375789) Hromas R … Lu L (Biochimica et biophysica acta 1997) 3 4 22 58

Products for GDF15 Gene