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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homo... See more...
Aliases for GDF15 Gene
Aliases for GDF15 Gene
- Growth/Differentiation Factor 15 3 4
- Macrophage Inhibitory Cytokine 1 3 4
- NSAID-Activated Gene 1 Protein 3 4
- NSAID-Regulated Gene 1 Protein 3 4
- Placental TGF-Beta 3 4
- GDF-15 3 4
- NRG-1 3 4
- NSAID (Nonsteroidal Anti-Inflammatory Drug)-Activated Protein 1 3
- Macrophage Inhibitory Cytokine-1 2
- PTGF-Beta 3
- GDF15 5
External Ids for GDF15 Gene
- HGNC: 30142
- Entrez Gene: 9518
- Ensembl: ENSG00000130513
- OMIM: 605312
- UniProtKB: Q99988
Previous GeneCards Identifiers for GDF15 Gene
- GC00U914343
- GC19P018318
- GC19P018358
- GC19P018496
- GC19P018613
- GC19P020499
- GC19P020641
- GC19P020745
- GC19P022252
- GC19P018542
- GC19P018556
- GC19P018720
- GC19P019032
- GC19P019349
- GC19P019680
- GC19P020047
- GC19P020359
Summaries for GDF15 Gene
-
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]
GeneCards Summary for GDF15 Gene
GDF15 (Growth Differentiation Factor 15) is a Protein Coding gene. Diseases associated with GDF15 include Heart Disease and Congenital Dyserythropoietic Anemia. Among its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is BMP8A.
UniProtKB/Swiss-Prot Summary for GDF15 Gene
-
Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).
Additional gene information for GDF15 Gene
- HGNC(30142)
- Entrez Gene(9518)
- Ensembl(ENSG00000130513)
- OMIM(605312)
- UniProtKB(Q99988)
- Open Targets Platform(ENSG00000130513)
- Monarch Initiative
- Search for GDF15 at DataMed
- Search for GDF15 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GDF15 Gene
Genomics for GDF15 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GDF15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GDF15 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GDF15
- Top Transcription factor binding sites by QIAGEN in the GDF15 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- C/EBPbeta
- PPAR-gamma1
- PPAR-gamma2
- STAT3
Genomic Locations for GDF15 Gene
Genomic Locations for GDF15 Gene
- chr19:18,374,731-18,389,176
- (GRCh38/hg38)
- Size:
- 14,446 bases
- Orientation:
- Plus strand
- chr19:18,485,541-18,499,986
- (GRCh37/hg19)
- Size:
- 14,446 bases
- Orientation:
- Plus strand
Genomic View for GDF15 Gene
Genes around GDF15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.11 by HGNC
- 19p13.11 by Entrez Gene
- 19p13.11 by Ensembl
GDF15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GDF15 Gene
Proteins for GDF15 Gene
-
Protein details for GDF15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99988-GDF15_HUMAN
- Recommended name:
- Growth/differentiation factor 15
- Protein Accession:
- Q99988
- O14629
- P78360
- Q9BWA0
- Q9NRT0
Protein attributes for GDF15 Gene
- Size:
- 308 amino acids
- Molecular mass:
- 34140 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked (PubMed:29046435). Interacts with GFRAL; ligand of GFRAL which mediates GDF15 internalization and cellular signaling through interaction with RET (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099).
Protein Expression for GDF15 Gene
Post-translational modifications for GDF15 Gene
Other Protein References for GDF15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents GDF15 Antibody
- Novus Biologicals Antibodies for GDF15
-
Abcam antibodies for GDF15
- Invitrogen Antibodies for GDF15 (AFLGC-Gdf15)
-
Santa Cruz Biotechnology (SCBT) Antibodies for GDF15
- Sino Biological Antibodies for GDF15
Protein Products
-
OriGene Purified Proteins for GDF15
- Search Origene for MassSpec and Protein Over-expression Lysates for GDF15
- Origene Custom Protein Services for GDF15
- Sino Biological Recombinant Proteins for GDF15
- Sino Biological Cell Lysates for GDF15
- ProSpec Recombinant Proteins for GDF15
-
Abcam proteins for GDF15
Assay Products
- RayBiotech Human GDF-15 ELISA
-
Abcam assays for GDF15
- Sino Biological Assays for GDF15
No data available for DME Specific Peptides for GDF15 Gene
Domains & Families for GDF15 Gene
Gene Families for GDF15 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for GDF15 Gene
- InterPro:
- Blocks:
-
- Transforming growth factor beta (TGFb)
- Growth factor cystine knot superfamily signature
- ProtoNet:
Suggested Antigen Peptide Sequences for GDF15 Gene
- GenScript: Design optimal peptide antigens:
-
- Prostate differentiation factor (GDF15_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q99988- Family:
-
- Belongs to the TGF-beta family.
Function for GDF15 Gene
Molecular function for GDF15 Gene
- UniProtKB/Swiss-Prot Function:
- Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Expression is up-regulated by obesity.
Phenotypes From GWAS Catalog for GDF15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | TAS,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 19060904 |
| GO:0008083 | growth factor activity | IEA | -- |
| GO:0042803 | protein homodimerization activity | IEA,IDA | 29046435 |
| GO:0070700 | BMP receptor binding | IBA | 21873635 |
Phenotypes for GDF15 Gene
- MGI mutant phenotypes for GDF15:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for GDF15:
Animal Models for GDF15 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for GDF15
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GDF15 - Select products 50% OFF >
- * GDF15 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GDF15
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GDF15
-
Santa Cruz Biotechnology (SCBT) CRISPR for GDF15
miRNA for GDF15 Gene
- miRTarBase miRNAs that target GDF15
-
- hsa-miR-335-5p (MIRT018703)
- hsa-miR-1225-3p (MIRT736096)
- hsa-miR-1233-3p (MIRT736208)
- hsa-miR-128-3p (MIRT737007)
- hsa-miR-1286 (MIRT737047)
- hsa-miR-140-3p (MIRT737573)
- hsa-miR-216a-3p (MIRT739022)
- hsa-miR-3665 (MIRT742047)
- hsa-miR-3681-3p (MIRT742193)
- hsa-miR-3692-3p (MIRT742529)
- hsa-miR-3914 (MIRT742871)
- hsa-miR-4436a (MIRT744431)
- hsa-miR-4436b-3p (MIRT744459)
- hsa-miR-4632-5p (MIRT746269)
- hsa-miR-5000-3p (MIRT749318)
- hsa-miR-549a (MIRT750843)
- hsa-miR-6721-5p (MIRT753795)
- hsa-miR-6735-5p (MIRT754172)
- hsa-miR-6807-5p (MIRT756521)
- hsa-miR-6879-5p (MIRT758259)
- hsa-miR-764 (MIRT759529)
- hsa-miR-7843-5p (MIRT759761)
- hsa-miR-937-3p (MIRT760700)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GDF15
- Browse OriGene Inhibitory RNA Products For GDF15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GDF15
Clone Products
- Applied Biological Materials (abm): Clones for GDF15 - Select products 50% OFF >
- * GDF15 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GDF15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GDF15
Cell Line Products
- ESI BIO PureStem SM30, NCr-fac & Meso-latp Progenitor for GDF15
-
Horizon Cell Lines for GDF15
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GDF15 Gene
Localization for GDF15 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GDF15 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| golgi apparatus | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| endosome | 1 |
| lysosome | 1 |
- Golgi apparatus (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS,IDA | 28572090 |
| GO:0005615 | extracellular space | IBA,IDA | 25893289 |
| GO:0005634 | nucleus | IDA | 25893289 |
| GO:0005737 | cytoplasm | IDA | 25893289 |
| GO:0005794 | Golgi apparatus | IDA | -- |
Pathways & Interactions for GDF15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
| 3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
Nanog in Mammalian ESC Pluripotency
.62
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
| 5 | CREB Pathway |
CREB Pathway
.68
IP3 Pathway
.68
|
Activation of PKC through GPCR
.63
Intracellular Calcium Signaling
.50
|
Pathways by source for GDF15 Gene
1 BioSystems pathway for GDF15 Gene
1 KEGG pathway for GDF15 Gene
54 Qiagen pathways for GDF15 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
3 Cell Signaling Technology pathways for GDF15 Gene
Interacting Proteins for GDF15 Gene
Selected Interacting proteins:
Q99988-GDF15_HUMAN
ENSP00000252809
for GDF15 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for GDF15
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IEA,IDA | 28953886 |
| GO:0002023 | reduction of food intake in response to dietary excess | IEA,IDA | 28846097 |
| GO:0007165 | signal transduction | TAS | 9326641 |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | TAS | 9348093 |
| GO:0007267 | cell-cell signaling | TAS | 9326641 |
Transcripts for GDF15 Gene
mRNA/cDNA for GDF15 Gene
- 1 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000252809 1200 nts (view in UCSC)
- ENST00000594925 294 nts (view in UCSC)
- ENST00000595973 890 nts (view in UCSC)
- ENST00000597765 562 nts (view in UCSC)
- ENST00000604609 506 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GDF15 - Select products 50% OFF >
- * GDF15 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GDF15
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GDF15
-
Santa Cruz Biotechnology (SCBT) CRISPR for GDF15
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GDF15
- Browse OriGene Inhibitory RNA Products For GDF15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GDF15
Clone Products
- Applied Biological Materials (abm): Clones for GDF15 - Select products 50% OFF >
- * GDF15 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GDF15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GDF15
Relevant External Links for GDF15 Gene
- GeneLoc Exon Structure for
- GDF15
Expression for GDF15 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
- Lateral Plate Mesoderm (Gastrulation Derivatives)
- Neural Crest (Gastrulation Derivatives)
- Adipose (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for GDF15 Gene
This gene is overexpressed in Bladder (x7.8), Kidney - Cortex (x6.3), Prostate (x5.0), and Pancreas (x4.1).
This gene is overexpressed in Amniocyte (24.2), Placenta (15.9), Lung (13.7), and Bone marrow mesenchymal stem cell (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GDF15 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GDF15
SOURCE GeneReport for Unigene cluster for GDF15 Gene:
Hs.616962mRNA Expression by UniProt/SwissProt for GDF15 Gene:
Q99988-GDF15_HUMAN
Tissue specificity:
Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney (PubMed:9348093). Detected in plasma (at protein level) (PubMed:28572090, PubMed:29046435).
Evidence on tissue expression from TISSUES for GDF15 Gene
- Skin(4.7)
- Muscle(4.7)
- Lung(4.4)
- Intestine(4.3)
- Kidney(4.2)
- Liver(4.1)
- Pancreas(3.6)
- Blood(2.9)
- Heart(2.9)
- Nervous system(2.9)
- Stomach(2.5)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs for GDF15
-
OriGene qPCR primer pairs and template standards for GDF15
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GDF15 Gene
Orthologs for GDF15 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GDF15 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GDF15 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GDF15 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gdf15 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Gdf15 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GDF15 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | GDF15 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | ndr1 31 |
|
ManyToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | daf-7 31 |
|
OneToOne |
- Species where no ortholog for GDF15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for GDF15 Gene
- ENSEMBL:
- Gene Tree for GDF15 (if available)
- TreeFam:
- Gene Tree for GDF15 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GDF15: view image
Paralogs for GDF15 Gene
Paralogs for GDF15 Gene
Variants for GDF15 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GDF15 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 716361 | Benign: not provided | 18,386,195(+) | C/T | SYNONYMOUS_VARIANT | |
| 744604 | Benign: not provided | 18,388,480(+) | C/A | SYNONYMOUS_VARIANT | |
| 780551 | Benign: not provided | 18,388,357(+) | G/A | MISSENSE_VARIANT | |
| 780552 | Benign: not provided | 18,388,358(+) | C/A | MISSENSE_VARIANT | |
| rs1058587 | - | p.His202Asp |
Residual Variation Intolerance Score:
26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.20;
90.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GDF15 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDF15 Gene
Disorders for GDF15 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| heart disease |
|
|
| congenital dyserythropoietic anemia |
|
|
| oral cavity cancer |
|
|
| colorectal cancer |
|
|
| pancreatic adenocarcinoma |
|
|
Search GDF15 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GDF15_HUMAN- Note=Plasma levels are increased in children with concomitant heart disease and failure to thrive but not in children with heart disease and normal body weight. {ECO:0000269 PubMed:28572090}.
Additional Disease Information for GDF15
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for GDF15 Gene
Publications for GDF15 Gene
- Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. (PMID: 11895857) Baek SJ … Eling TE (Carcinogenesis 2002) 2 3 23
- Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. (PMID: 11259636) Baek SJ … Eling TE (Molecular pharmacology 2001) 3 4 23
- Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family. (PMID: 9593718) Paralkar VM … Thompson DD (The Journal of biological chemistry 1998) 2 3 4
- PLAB, a novel placental bone morphogenetic protein. (PMID: 9375789) Hromas R … Lu L (Biochimica et biophysica acta 1997) 3 4 23
- MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. (PMID: 9326641) Bootcov MR … Breit SN (Proceedings of the National Academy of Sciences of the United States of America 1997) 3 4 23
ExternalLinks
Products for GDF15 Gene
- View all 17 R&D Systems GDF15 (GDF-15) Products
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- View all 7 R&D Systems GDF15 (GDF-15) Primary Antibodies
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- Learn more about R&D Systems custom GDF15 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for GDF15
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- Browse OriGene Inhibitory RNA Products For GDF15
- OriGene qPCR primer pairs for GDF15
- OriGene qPCR primer pairs and template standards for GDF15
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for GDF15
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- Novus Biologicals Antibodies for GDF15
- Novus Biologicals proteins and lysates for GDF15
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- ProSpec Recombinant Proteins for GDF15
- ESI BIO PureStem SM30, NCr-fac & Meso-latp Progenitor for GDF15
- Taconic Biosciences Mouse Models for GDF15
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for GDF15 (AFLGC-Gdf15)
- VectorBuilder Custom and pre-made DNA vectors for GDF15 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GDF15 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GDF15 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GDF15 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GDF15
- antibodies-online: Show 106 available GDF15 Antibodies ranked by validation data
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- antibodies-online: Show 94 available GDF15 Elisa Kits ranked by validation data
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- antibodies-online: Show 39 available GDF15 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for GDF15
- Search Santa Cruz Biotechnology (SCBT) for GDF15 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GDF15
- Horizon Cell Lines for GDF15
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GDF15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GDF15
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GDF15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GDF15
Sources for GDF15 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB