Aliases for GDF15 Gene
Aliases for GDF15 Gene
- Growth Differentiation Factor 15 2 3 5
- Prostate Differentiation Factor 2 3 4
- Non-Steroidal Anti-Inflammatory Drug-Activated Gene-1 2 3
- Placental Bone Morphogenetic Protein 3 4
- Macrophage Inhibitory Cytokine 1 3 4
- NSAID-Activated Gene 1 Protein 3 4
- NSAID-Regulated Gene 1 Protein 3 4
- Placental TGF-Beta 3 4
- GDF-15 3 4
- MIC-1 3 4
- NAG-1 3 4
External Ids for GDF15 Gene
- HGNC: 30142
- Entrez Gene: 9518
- Ensembl: ENSG00000130513
- OMIM: 605312
- UniProtKB: Q99988
Previous GeneCards Identifiers for GDF15 Gene
- GC00U914343
- GC19P018318
- GC19P018358
- GC19P018496
- GC19P018613
- GC19P018542
- GC19P018556
- GC19P018720
- GC19P019032
- GC19P019349
Summaries for GDF15 Gene
-
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]
GeneCards Summary for GDF15 Gene
GDF15 (Growth Differentiation Factor 15) is a Protein Coding gene. Diseases associated with GDF15 include Pulmonary Systemic Sclerosis and Oral Cavity Cancer. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is GDF1.
Additional gene information for GDF15 Gene
- Monarch Initiative
- Search for GDF15 at DataMed
- Search for GDF15 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDF15 Gene
Genomics for GDF15 Gene
GeneHancer (GH) Regulatory Elements for GDF15 Gene
Promoters and enhancers for GDF15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GDF15 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GDF15 gene promoter:
Regulatory Element Products
Genomic Locations for GDF15 Gene
Genomic Locations for GDF15 Gene
- chr19:18,374,731-18,389,176
- (GRCh38/hg38)
- Size:
- 14,446 bases
- Orientation:
- Plus strand
- chr19:18,485,541-18,499,986
- (GRCh37/hg19)
Genomic View for GDF15 Gene
Genes around GDF15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.11 by Ensembl
- 19p13.11 by Entrez Gene
- 19p13.11 by HGNC
GDF15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GDF15 Gene
Proteins for GDF15 Gene
-
Protein details for GDF15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99988-GDF15_HUMAN
- Recommended name:
- Growth/differentiation factor 15
- Protein Accession:
- Q99988
- O14629
- P78360
- Q9BWA0
- Q9NRT0
Protein attributes for GDF15 Gene
- Size:
- 308 amino acids
- Molecular mass:
- 34140 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked.
Protein Expression for GDF15 Gene
Post-translational modifications for GDF15 Gene
- Glycosylation at posLast=4444 and posLast=7070
Other Protein References for GDF15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for GDF15 (GDF-15)
- Cell Signaling Technology (CST) Antibodies for GDF15 (GDF15)
- Novus Biologicals Antibodies for GDF15
-
Abcam antibodies for GDF15
-
Cloud-Clone Corp. Antibodies for GDF15
- Invitrogen Antibodies for GDF15
- antibodies-online: Search results for 272 available C18orf8 Antibodies ranked by validation data
- Compare Top C18orf8 Antibodies
-
Recommended
- 193 WB Antibodies (anti-human)
- 15 IF (p) Antibodies (anti-human)
- 13 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 53 WB Antibodies (anti-mouse)
- 15 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 59 WB Antibodies (anti-rat)
- 15 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 193 WB Antibodies (anti-human)
- 15 IF (p) Antibodies (anti-human)
- 13 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 53 WB Antibodies (anti-mouse)
- 15 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 59 WB Antibodies (anti-rat)
- 15 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 193 WB Antibodies (anti-human)
- 15 IF (p) Antibodies (anti-human)
- 13 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 53 WB Antibodies (anti-mouse)
- 15 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 59 WB Antibodies (anti-rat)
- 15 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- GeneTex GDF15 antibody for GDF15
-
Santa Cruz Biotechnology (SCBT) Antibodies for GDF15
Protein Products
- R&D Systems Proteins and Enzymes for GDF15 (GDF-15)
-
OriGene Purified Proteins for GDF15
- Search Origene for MassSpec and Protein Over-expression Lysates for GDF15
- Origene Custom Protein Services for GDF15
- Sino Biological Recombinant Proteins for GDF15
- Sino Biological Cell Lysates for GDF15
- ProSpec Recombinant Proteins for GDF15
-
Cloud-Clone Corp. Proteins for GDF15
- antibodies-online: Search results for 42 available C18orf8 Proteins ranked by validation data
- Compare Top C18orf8 Proteins
-
Quality Products:
- ABIN3078883
- ABIN3120206
- ABIN2003620
- ABIN809751
- ABIN5311517
- ABIN666670
- ABIN2721778
- ABIN1079752
- ABIN4370532
- ABIN1525436
- ABIN4370532
- ABIN1079752
- ABIN2721778
- ABIN666670
- ABIN5311517
- ABIN809751
- ABIN2003620
- ABIN3120206
- ABIN3078883
- ABIN1525436
- ABIN4370532
- ABIN1079752
- ABIN2721778
- ABIN666670
- ABIN5311517
- ABIN809751
- ABIN2003620
- ABIN3120206
- ABIN3078883
- ABIN1525436
- GeneTex Proteins for GDF15
-
Abcam proteins for GDF15
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for GDF15 (GDF-15)
- Novus Biologicals ELISA Kits for GDF15
- antibodies-online: Search results for 81 available C18orf8 Elisa Kits ranked by validation data
- Compare Top C18orf8 Elisa Kits
-
Quality Products:
- ABIN365728
- ABIN1706082
- ABIN431624
- ABIN5592143
- ABIN1562936
- ABIN1562937
- ABIN1562939
- ABIN1562940
- ABIN5592144
- ABIN1054306
- ABIN365728
- ABIN1706082
- ABIN431624
- ABIN5592143
- ABIN1562936
- ABIN1562937
- ABIN1562939
- ABIN1562940
- ABIN5592144
- ABIN1054306
- ABIN365728
- ABIN1706082
- ABIN431624
- ABIN5592143
- ABIN1562936
- ABIN1562937
- ABIN1562939
- ABIN1562940
- ABIN5592144
- ABIN1054306
-
Abcam assays for GDF15
No data available for DME Specific Peptides for GDF15 Gene
Domains & Families for GDF15 Gene
Gene Families for GDF15 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for GDF15 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GDF15 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99988- Family:
-
- Belongs to the TGF-beta family.
Function for GDF15 Gene
Phenotypes From GWAS Catalog for GDF15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IBA | -- |
| GO:0005160 | transforming growth factor beta receptor binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 19060904 |
| GO:0008083 | growth factor activity | IEA | -- |
Phenotypes for GDF15 Gene
- MGI mutant phenotypes for GDF15:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for GDF15:
Animal Models for GDF15 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GDF15
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GDF15 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GDF15 gene
- Search ViGene Biosciences for GDF15
CRISPR Products
-
OriGene CRISPR knockouts for GDF15
- genomics-online: gRNA clones - Search results for 41 available Neuregulin 1 gene related products
- Overview of 41 available Neuregulin 1 gene related products
-
Recommended
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
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- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
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- pLenti-C-Myc-DDK
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- pRS
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- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- Applied Biological Materials CRISPR for GDF15
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GDF15
- GenScript: Design CRISPR guide RNA sequences for GDF15
miRNA for GDF15 Gene
- miRTarBase miRNAs that target GDF15
-
- hsa-mir-335-5p (MIRT018703)
- hsa-mir-1225-3p (MIRT736096)
- hsa-mir-1233-3p (MIRT736208)
- hsa-mir-128-3p (MIRT737007)
- hsa-mir-1286 (MIRT737047)
- hsa-mir-140-3p (MIRT737573)
- hsa-mir-216a-3p (MIRT739022)
- hsa-mir-3665 (MIRT742047)
- hsa-mir-3681-3p (MIRT742193)
- hsa-mir-3692-3p (MIRT742529)
- hsa-mir-3914 (MIRT742871)
- hsa-mir-4436a (MIRT744431)
- hsa-mir-4436b-3p (MIRT744459)
- hsa-mir-4632-5p (MIRT746269)
- hsa-mir-5000-3p (MIRT749318)
- hsa-mir-549a (MIRT750843)
- hsa-mir-6721-5p (MIRT753795)
- hsa-mir-6735-5p (MIRT754172)
- hsa-mir-6807-5p (MIRT756521)
- hsa-mir-6879-5p (MIRT758259)
- hsa-mir-764 (MIRT759529)
- hsa-mir-7843-5p (MIRT759761)
- hsa-mir-937-3p (MIRT760700)
miRNA Products
- Search ViGene Biosciences for GDF15
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GDF15
- Browse OriGene Inhibitory RNA Products For GDF15
- genomics-online: shRNA clones - Search results for 41 available Neuregulin 1 gene related products
- Overview of 41 available Neuregulin 1 gene related products
-
Recommended
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
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- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
-
ViGene Biosciences ready-to-package AAV shRNAs for GDF15 gene
Clone Products
- Sino Biological Human cDNA Clone for GDF15
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for GDF15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GDF15
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 41 available Neuregulin 1 gene related products
- Overview of 41 available Neuregulin 1 gene related products
-
Recommended
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- orf clones - Search results for 41 available Neuregulin 1 gene related products
- Overview of 41 available Neuregulin 1 gene related products
-
Recommended
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- Applied Biological Materials Clones for GDF15
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem SM30, NCr-fac & Meso-latp Progenitor for GDF15
-
Horizon Cell Lines for GDF15
-
ViGene Biosciences adenoviral particle packaged cDNA for GDF15 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GDF15 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GDF15 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GDF15 Gene
Localization for GDF15 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GDF15 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Golgi apparatus (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | 9326641 |
| GO:0005615 | extracellular space | IEA,IDA | 25893289 |
| GO:0005634 | nucleus | IDA | 25893289 |
| GO:0005737 | cytoplasm | IDA | 25893289 |
| GO:0005794 | Golgi apparatus | IDA | -- |
Pathways & Interactions for GDF15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 2 | GPCR Pathway |
.73
.62
|
.55
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
| 5 | CREB Pathway |
.68
.68
|
|
Pathways by source for GDF15 Gene
3 Cell Signaling Technology pathways for GDF15 Gene
1 BioSystems pathway for GDF15 Gene
Interacting Proteins for GDF15 Gene
Selected Interacting proteins:
ENSP00000252809
Q99988-GDF15_HUMAN
for GDF15 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | 9326641 |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | TAS | 9348093 |
| GO:0007267 | cell-cell signaling | TAS | 9326641 |
| GO:0010469 | regulation of receptor activity | IEA | -- |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | IBA | -- |
No data available for SIGNOR curated interactions for GDF15 Gene
Transcripts for GDF15 Gene
mRNA/cDNA for GDF15 Gene
- (1) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (1271) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GDF15 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GDF15
- genomics-online: gRNA clones - Search results for 41 available Neuregulin 1 gene related products
- Overview of 41 available Neuregulin 1 gene related products
-
Recommended
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- Applied Biological Materials CRISPR for GDF15
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GDF15
- GenScript: Design CRISPR guide RNA sequences for GDF15
miRNA Products
- Search ViGene Biosciences for GDF15
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GDF15
- Browse OriGene Inhibitory RNA Products For GDF15
- genomics-online: shRNA clones - Search results for 41 available Neuregulin 1 gene related products
- Overview of 41 available Neuregulin 1 gene related products
-
Recommended
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
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-
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- Applied Biological Materials Clones for GDF15
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for GDF15 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
- Cartilage (Muscoskeletal System)
- Adipose (Muscoskeletal System)
- Neural Crest (Gastrulation Derivatives)
- Lateral Plate Mesoderm (Gastrulation Derivatives)
-
Pancreas (Endocrine System)
-
Liver (Hepatobiliary System)
-
Kidney (Urinary System)
-
Lung (Respiratory System)
-
Placenta (Extraembryonic Tissues)
-
Prostate (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for GDF15 Gene
This gene is overexpressed in Bladder (x7.8), Kidney - Cortex (x6.3), Prostate (x5.0), and Pancreas (x4.1).
This gene is overexpressed in Amniocyte (24.2), Placenta (15.9), Lung (13.7), and Bone marrow mesenchymal stem cell (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GDF15 Gene
NURSA nuclear receptor signaling pathways regulating expression of GDF15 Gene:
GDF15SOURCE GeneReport for Unigene cluster for GDF15 Gene:
Hs.616962mRNA Expression by UniProt/SwissProt for GDF15 Gene:
Q99988-GDF15_HUMAN
Tissue specificity:
Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney.
Evidence on tissue expression from TISSUES for GDF15 Gene
- Muscle(4.6)
- Skin(4.6)
- Lung(4.3)
- Intestine(4.1)
- Kidney(3.9)
- Liver(3.8)
- Pancreas(2.9)
- Blood(2.4)
- Heart(2.3)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for GDF15
-
OriGene qPCR primer pairs and template standards for GDF15
- genomics-online: primer clones - Search results for 41 available Neuregulin 1 gene related products
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Recommended
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- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
- pPB-His-MBP
- pPB-His-GST
- pGFP-C-shLenti
- pRFP-C-RS
- pGFP-V-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
- pRS
- pCMV6-AC-GFP
- pPB-N-His
- pPB-C-His
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- pPB-His-GST
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- pRFP-C-RS
- pGFP-V-RS
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- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-AC
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GDF15 Gene
Orthologs for GDF15 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GDF15 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | GDF15 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | GDF15 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gdf15 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Gdf15 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GDF15 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GDF15 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | ndr1 34 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | daf-7 34 |
|
OneToOne |
- Species where no ortholog for GDF15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for GDF15 Gene
Variants for GDF15 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000290705 | -- | 18,386,761(+) | C/G | intron_variant | |
| rs1000641221 | -- | 18,387,158(+) | A/G | intron_variant | |
| rs1002465534 | -- | 18,384,767(+) | T/C | upstream_transcript_variant | |
| rs1003080580 | -- | 18,385,151(+) | T/C | upstream_transcript_variant | |
| rs1004319159 | -- | 18,384,576(+) | C/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.20;
90.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GDF15 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDF15 Gene
Disorders for GDF15 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pulmonary systemic sclerosis |
|
|
| oral cavity cancer |
|
|
| colorectal cancer |
|
|
| prostate cancer |
|
|
| heart disease |
|
Search GDF15 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GDF15
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GDF15 Gene
Publications for GDF15 Gene
- Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. (PMID: 11895857) Baek SJ … Eling TE (Carcinogenesis 2002) 2 3 22 58
- Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. (PMID: 11259636) Baek SJ … Eling TE (Molecular pharmacology 2001) 3 4 22 58
- Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family. (PMID: 9593718) Paralkar VM … Thompson DD (The Journal of biological chemistry 1998) 2 3 4 58
- PLAB, a novel placental bone morphogenetic protein. (PMID: 9375789) Hromas R … Lu L (Biochimica et biophysica acta 1997) 3 4 22 58
- MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. (PMID: 9326641) Bootcov MR … Breit SN (Proceedings of the National Academy of Sciences of the United States of America 1997) 3 4 22 58
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- genomics-online: cdna clones - Search results for 41 available C18orf8 gene related products
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