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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homo... See more...
Aliases for GDF11 Gene
Aliases for GDF11 Gene
External Ids for GDF11 Gene
- HGNC: 4216
- Entrez Gene: 10220
- Ensembl: ENSG00000135414
- OMIM: 603936
- UniProtKB: O95390
Previous GeneCards Identifiers for GDF11 Gene
- GC12P056061
- GC12P056210
- GC12P055853
- GC12P054423
- GC12P056137
- GC12P053175
Summaries for GDF11 Gene
-
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]
GeneCards Summary for GDF11 Gene
GDF11 (Growth Differentiation Factor 11) is a Protein Coding gene. Diseases associated with GDF11 include Currarino Syndrome and Renal Hypodysplasia/Aplasia 1. Among its related pathways are PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is MSTN.
UniProtKB/Swiss-Prot Summary for GDF11 Gene
-
Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634).
Additional gene information for GDF11 Gene
- HGNC(4216)
- Entrez Gene(10220)
- Ensembl(ENSG00000135414)
- OMIM(603936)
- UniProtKB(O95390)
- Open Targets Platform(ENSG00000135414)
- Search for GDF11 at DataMed
- Search for GDF11 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GDF11 Gene
Genomics for GDF11 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GDF11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GDF11 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GDF11
- Top Transcription factor binding sites by QIAGEN in the GDF11 gene promoter:
-
- c-Ets-1
- C/EBPbeta
- GR
- GR-alpha
- GR-beta
- HEN1
- LyF-1
- Nkx2-5
- Sp1
Genomic Locations for GDF11 Gene
Genomic Locations for GDF11 Gene
- chr12:55,743,122-55,757,264
- (GRCh38/hg38)
- Size:
- 14,143 bases
- Orientation:
- Plus strand
- chr12:56,137,064-56,150,911
- (GRCh37/hg19)
- Size:
- 13,848 bases
- Orientation:
- Plus strand
Genomic View for GDF11 Gene
Genes around GDF11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.2 by HGNC
- 12q13.2 by Entrez Gene
- 12q13.2 by Ensembl
GDF11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GDF11 Gene
Proteins for GDF11 Gene
-
Protein details for GDF11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95390-GDF11_HUMAN
- Recommended name:
- Growth/differentiation factor 11
- Protein Accession:
- O95390
- Q9UID1
- Q9UID2
Protein attributes for GDF11 Gene
- Size:
- 407 amino acids
- Molecular mass:
- 45091 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked (PubMed:26919518). Interacts directly with ACVR2B (By similarity). Interacts directly with ACVR2A (By similarity). Interacts with ACVR1B, TGFBR1 and ACVR1C in an ACVR2B-dependent manner (By similarity). Interacts with FST isoform 2/FS-288 (PubMed:28257634).
Protein Expression for GDF11 Gene
Post-translational modifications for GDF11 Gene
- Synthesized as large precursor molecule that undergoes proteolytic cleavage. The mature C-terminal portion of the molecule is bound non-covalently to its N-terminal propeptide rendering it inactive. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.
-
Glycosylation at Asn94
- NX_O95390 (NX_O95390-1)
- Modification sites at PhosphoSitePlus
Other Protein References for GDF11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GDF11 Antibody
- NSJ Bioreagents GDF11 Antibody
- HUABIO BMP11 Antibody (R1510-15)
-
Custom Antibody ServicesOriGene Antibodies for GDF11
- Novus Biologicals Antibodies for GDF11
-
Abcam antibodies for GDF11
- Invitrogen Antibodies for GDF11 (AFLGC-GDF11)
-
Boster Bio Antibodies for GDF11
-
Santa Cruz Biotechnology (SCBT) Antibodies for GDF11
Protein Products
- G Biosciences Human GDF-11/BMP-11, Lyophilized
- RayBiotech Recombinant Human GDF11
-
OriGene Purified Proteins for GDF11
- Search Origene for MassSpec and Protein Over-expression Lysates for GDF11
- Origene Custom Protein Services for GDF11
- Novus Biologicals proteins for GDF11
- ProSpec Recombinant Proteins for GDF11
-
ProSci Proteins for GDF11
-
Abcam proteins for GDF11
No data available for DME Specific Peptides for GDF11 Gene
Domains & Families for GDF11 Gene
Gene Families for GDF11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for GDF11 Gene
- InterPro:
- Blocks:
-
- Transforming growth factor beta (TGFb), N-terminal
- Transforming growth factor beta (TGFb)
- ProtoNet:
Suggested Antigen Peptide Sequences for GDF11 Gene
- GenScript: Design optimal peptide antigens:
-
- Bone morphogenetic protein 11 (GDF11_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95390- Family:
-
- Belongs to the TGF-beta family.
Function for GDF11 Gene
Molecular function for GDF11 Gene
- UniProtKB/Swiss-Prot Function:
- Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634).
LifeMap Function Summary for GDF11 Gene
During embryonic development, GDF11 as signaling molecule is secreted from the following cells
- Paraxial Mesoderm
It affects the following cells:
- Paraxial Mesoderm
Phenotypes From GWAS Catalog for GDF11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 18596030 |
| GO:0008083 | growth factor activity | IEA | -- |
Phenotypes for GDF11 Gene
- MGI mutant phenotypes for GDF11:
-
inferred from 6 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- renal/urinary system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- embryo phenotype
- craniofacial phenotype
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for GDF11:
-
- no effect
- Decreased Salmonella enterica Typhimurium invasion
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Decreased shRNA abundance (Z-score < -2)
- Decreased epidermal growth factor (EGF) endocytosis
Animal Models for GDF11 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GDF11 - Select products 50% OFF >
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-
OriGene CRISPR knockouts for GDF11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GDF11
-
Santa Cruz Biotechnology (SCBT) CRISPR for GDF11
miRNA for GDF11 Gene
- miRTarBase miRNAs that target GDF11
-
- hsa-miR-26b-5p (MIRT029928)
- hsa-miR-423-5p (MIRT038028)
- hsa-miR-615-3p (MIRT040475)
- hsa-miR-18a-3p (MIRT040960)
- hsa-miR-17-5p (MIRT050946)
- hsa-let-7b-5p (MIRT052163)
- hsa-miR-20a-5p (MIRT065858)
- hsa-miR-93-5p (MIRT065859)
- hsa-miR-106a-5p (MIRT065860)
- hsa-miR-142-5p (MIRT065862)
- hsa-miR-106b-5p (MIRT065863)
- hsa-miR-302a-3p (MIRT065864)
- hsa-miR-302b-3p (MIRT065865)
- hsa-miR-302c-3p (MIRT065866)
- hsa-miR-302d-3p (MIRT065867)
- hsa-miR-372-3p (MIRT065868)
- hsa-miR-373-3p (MIRT065869)
- hsa-miR-20b-5p (MIRT065870)
- hsa-miR-520e (MIRT065871)
- hsa-miR-519c-3p (MIRT065872)
- hsa-miR-520a-3p (MIRT065873)
- hsa-miR-526b-3p (MIRT065874)
- hsa-miR-519b-3p (MIRT065875)
- hsa-miR-520b (MIRT065876)
- hsa-miR-520c-3p (MIRT065877)
- hsa-miR-519d-3p (MIRT065878)
- hsa-miR-520d-3p (MIRT065879)
- hsa-miR-519a-3p (MIRT065880)
- hsa-miR-302e (MIRT065881)
- hsa-miR-3912-5p (MIRT065882)
- hsa-miR-371b-3p (MIRT065883)
- hsa-miR-5590-3p (MIRT065884)
- hsa-miR-548s (MIRT495310)
- hsa-miR-3926 (MIRT495311)
- hsa-miR-3190-5p (MIRT495312)
- hsa-miR-6756-3p (MIRT495313)
- hsa-miR-3127-3p (MIRT495314)
- hsa-miR-6794-5p (MIRT495315)
- hsa-miR-4716-3p (MIRT495316)
- hsa-miR-193b-3p (MIRT495317)
- hsa-miR-193a-3p (MIRT495318)
- hsa-miR-452-3p (MIRT542948)
- hsa-miR-3934-3p (MIRT542949)
- hsa-miR-6834-3p (MIRT542950)
- hsa-miR-4760-3p (MIRT542951)
- hsa-miR-4796-3p (MIRT542952)
- hsa-miR-548ah-5p (MIRT542953)
- hsa-miR-3609 (MIRT542954)
- hsa-miR-4313 (MIRT724567)
- hsa-miR-324-3p (MIRT724568)
- hsa-miR-1913 (MIRT724569)
- hsa-miR-8485 (MIRT724570)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GDF11
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Clone Products
- Applied Biological Materials (abm): Clones for GDF11 - Select products 50% OFF >
- * GDF11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for GDF11
- Addgene plasmids for GDF11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GDF11
Cell Line Products
-
Horizon Cell Lines for GDF11
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GDF11 Gene
Localization for GDF11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GDF11 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| nucleus | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0032991 | protein-containing complex | IDA | 24019467 |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
Pathways & Interactions for GDF11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling | ||
Pathways by source for GDF11 Gene
1 KEGG pathway for GDF11 Gene
Interacting Proteins for GDF11 Gene
Selected Interacting proteins:
O95390-GDF11_HUMAN
ENSP00000257868
for GDF11 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for GDF11
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | TAS | 10391213 |
| GO:0001656 | metanephros development | IEA | -- |
| GO:0001657 | ureteric bud development | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007399 | nervous system development | TAS | 10075854 |
Drugs & Compounds for GDF11 Gene
No Compound Related Data Available
Transcripts for GDF11 Gene
mRNA/cDNA for GDF11 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000257868 8801 nts (view in UCSC)
- ENST00000546799 1258 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GDF11 - Select products 50% OFF >
- * GDF11 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GDF11
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GDF11
-
Santa Cruz Biotechnology (SCBT) CRISPR for GDF11
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GDF11
- Browse OriGene Inhibitory RNA Products For GDF11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GDF11
Clone Products
- Applied Biological Materials (abm): Clones for GDF11 - Select products 50% OFF >
- * GDF11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GDF11
- Addgene plasmids for GDF11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GDF11
Relevant External Links for GDF11 Gene
- GeneLoc Exon Structure for
- GDF11
Expression for GDF11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Paraxial Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
-
Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm Cells Trunk Mesoderm
-
Eye (Sensory Organs)
- Mature Ganglion Cells Ganglion Cell Layer
-
Neurons
- Mature Ganglion Cells Ganglion Cell Layer
This gene is overexpressed in Bone (67.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GDF11 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GDF11
SOURCE GeneReport for Unigene cluster for GDF11 Gene:
Hs.600883Evidence on tissue expression from TISSUES for GDF11 Gene
- Nervous system(4.6)
- Heart(3)
- Eye(2.9)
- Muscle(2.8)
- Kidney(2.4)
- Spleen(2.4)
- Lung(2.2)
- Blood(2)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for GDF11
-
OriGene qPCR primer pairs and template standards for GDF11
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GDF11 Gene
Orthologs for GDF11 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GDF11 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GDF11 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GDF11 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gdf11 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gdf11 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | GDF11 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GDF11 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gdf11 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13638 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | gdf11 30 31 |
|
OneToOne | |
| gdf8 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.119 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005289 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | myo 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | daf-7 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for GDF11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GDF11 Gene
- ENSEMBL:
- Gene Tree for GDF11 (if available)
- TreeFam:
- Gene Tree for GDF11 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GDF11: view image
Paralogs for GDF11 Gene
Paralogs for GDF11 Gene
(2) SIMAP similar genes for GDF11 Gene using alignment to 2 proteins:
- GDF11_HUMAN
- H0YI30_HUMAN
Variants for GDF11 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GDF11 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1449282134 | Uncertain Significance: GDF11-associated multiple congenital anomalies and ID | 55,749,666(+) | C/G | NONSENSE |
Residual Variation Intolerance Score:
29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.45;
9.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GDF11 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDF11 Gene
Disorders for GDF11 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| currarino syndrome |
|
|
| renal hypodysplasia/aplasia 1 |
|
|
| aplastic anemia |
|
|
| osteoporosis |
|
|
Search GDF11 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GDF11
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GDF11 Gene
Publications for GDF11 Gene
- GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cells. (PMID: 15988002) Ge G … Greenspan DS (Molecular and cellular biology 2005) 2 3 23
- Structural basis for potency differences between GDF8 and GDF11. (PMID: 28257634) Walker RG … Thompson TB (BMC biology 2017) 3 4
- Crystal structure of human GDF11. (PMID: 26919518) Padyana AK … Farrow NA (Acta crystallographica. Section F, Structural biology communications 2016) 3 4
- A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 41
- Clinical significance of growth differentiation factor 11 in colorectal cancer. (PMID: 17912435) Yokoe T … Mori M (International journal of oncology 2007) 3 23
ExternalLinks
Products for GDF11 Gene
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- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for GDF11 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GDF11 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GDF11 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GDF11 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GDF11
- Addgene plasmids for GDF11
- antibodies-online: Show 16 available GDF11 Antibodies ranked by validation data
- Compare Top GDF11 Antibodies
- antibodies-online: Show 78 available GDF11 Elisa Kits ranked by validation data
- Compare Top GDF11 Elisa Kits
- Quality Products:
- antibodies-online: Show 30 available GDF11 Proteins ranked by validation data
- Compare Top GDF11 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for GDF11
- Search Santa Cruz Biotechnology (SCBT) for GDF11 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GDF11
- Horizon Cell Lines for GDF11
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GDF11
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GDF11
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GDF11
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GDF11
- Boster Bio Antibodies for GDF11
- Browse Boster Bio ELISA Kits
Sources for GDF11 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB