Aliases for GDF1 Gene
External Ids for GDF1 Gene
Previous GeneCards Identifiers for GDF1 Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Jul 2016]
GeneCards Summary for GDF1 Gene
GDF1 (Growth Differentiation Factor 1) is a Protein Coding gene. Diseases associated with GDF1 include Right Atrial Isomerism and Congenital Heart Defects, Multiple Types, 6. Among its related pathways are Developmental Biology and Metabolism. Gene Ontology (GO) annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is CERS1.
UniProtKB/Swiss-Prot Summary for GDF1 Gene
May mediate cell differentiation events during embryonic development.