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Aliases for GCSAML Gene

Aliases for GCSAML Gene

  • Germinal Center Associated Signaling And Motility Like 2 3 5
  • C1orf150 3 4
  • Germinal Center-Associated Signaling And Motility-Like Protein 3
  • Chromosome 1 Open Reading Frame 150 2

External Ids for GCSAML Gene

Previous HGNC Symbols for GCSAML Gene

  • C1orf150

Previous GeneCards Identifiers for GCSAML Gene

  • GC01P247671

Summaries for GCSAML Gene

Entrez Gene Summary for GCSAML Gene

  • This gene encodes a protein thought to be a signaling molecule associated with germinal centers, the sites of proliferation and differentiation of mature B lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for GCSAML Gene

GCSAML (Germinal Center Associated Signaling And Motility Like) is a Protein Coding gene.

Additional gene information for GCSAML Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCSAML Gene

Genomics for GCSAML Gene

GeneHancer (GH) Regulatory Elements for GCSAML Gene

Promoters and enhancers for GCSAML Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J247548 Promoter/Enhancer 1.2 EPDnew Ensembl 650.3 +41.7 41743 0.8 HDAC1 MEIS2 TAF9B TEAD4 TAL1 MAX TCF12 ZNF766 NCOR1 POLR2A GCSAML ZNF124 OR2C3 PIR40872
GH01J247507 Promoter 0.5 EPDnew 650.7 +0.0 47 0.1 GCSAML GCSAML-AS1
GH01J247553 Enhancer 0.3 FANTOM5 98.4 +45.4 45387 0.2 GCSAML OR2G2 OR2C3 PIR40872
GH01J247551 Enhancer 0.3 FANTOM5 47 +44.7 44726 0.2 GCSAML OR2G2 OR2C3 PIR40872
GH01J247557 Enhancer 0.4 FANTOM5 20.4 +50.7 50714 0.3 GABPA GCSAML OR2G2 OR2C3 OR2G3 ZNF496 PIR40872
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GCSAML on UCSC Golden Path with GeneCards custom track

Genomic Locations for GCSAML Gene

Genomic Locations for GCSAML Gene
chr1:247,507,058-247,577,690
(GRCh38/hg38)
Size:
70,633 bases
Orientation:
Plus strand
chr1:247,670,360-247,740,992
(GRCh37/hg19)
Size:
70,633 bases
Orientation:
Plus strand

Genomic View for GCSAML Gene

Genes around GCSAML on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCSAML Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCSAML Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCSAML Gene

Proteins for GCSAML Gene

  • Protein details for GCSAML Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JQS6-GSAML_HUMAN
    Recommended name:
    Germinal center-associated signaling and motility-like protein
    Protein Accession:
    Q5JQS6
    Secondary Accessions:
    • B2R4Y5
    • B3KX46
    • Q5JQT3

    Protein attributes for GCSAML Gene

    Size:
    135 amino acids
    Molecular mass:
    15712 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GCSAML Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GCSAML Gene

Post-translational modifications for GCSAML Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GCSAML Gene

Domains & Families for GCSAML Gene

Gene Families for GCSAML Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GCSAML Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GCSAML: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GCSAML Gene

Function for GCSAML Gene

Phenotypes From GWAS Catalog for GCSAML Gene

genes like me logo Genes that share phenotypes with GCSAML: view

Animal Model Products

miRNA for GCSAML Gene

miRTarBase miRNAs that target GCSAML

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GCSAML Gene

Localization for GCSAML Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GCSAML gene
Compartment Confidence
nucleus 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GCSAML Gene

Pathways & Interactions for GCSAML Gene

SuperPathways for GCSAML Gene

No Data Available

Interacting Proteins for GCSAML Gene

Gene Ontology (GO) - Biological Process for GCSAML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050855 regulation of B cell receptor signaling pathway IEA --
GO:2000401 regulation of lymphocyte migration IEA --
genes like me logo Genes that share ontologies with GCSAML: view

No data available for Pathways by source and SIGNOR curated interactions for GCSAML Gene

Drugs & Compounds for GCSAML Gene

No Compound Related Data Available

Transcripts for GCSAML Gene

mRNA/cDNA for GCSAML Gene

Unigene Clusters for GCSAML Gene

Germinal center-associated, signaling and motility-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GCSAML Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for GCSAML Gene

GeneLoc Exon Structure for
GCSAML
ECgene alternative splicing isoforms for
GCSAML

Expression for GCSAML Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GCSAML Gene

mRNA differential expression in normal tissues according to GTEx for GCSAML Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.1), Brain - Cerebellum (x7.5), Testis (x5.7), and Prostate (x5.3).

Protein differential expression in normal tissues from HIPED for GCSAML Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.6), Bone (25.2), and Breast (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GCSAML Gene



Protein tissue co-expression partners for GCSAML Gene

NURSA nuclear receptor signaling pathways regulating expression of GCSAML Gene:

GCSAML

SOURCE GeneReport for Unigene cluster for GCSAML Gene:

Hs.732113

Evidence on tissue expression from TISSUES for GCSAML Gene

  • Nervous system(4.1)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with GCSAML: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GCSAML Gene

Orthologs for GCSAML Gene

This gene was present in the common ancestor of mammals.

Orthologs for GCSAML Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GCSAML 34 33
  • 99.75 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GCSAML 34 33
  • 83.08 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC101903568 33
  • 81.25 (n)
Species where no ortholog for GCSAML was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GCSAML Gene

ENSEMBL:
Gene Tree for GCSAML (if available)
TreeFam:
Gene Tree for GCSAML (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GCSAML: view image

Paralogs for GCSAML Gene

(1) SIMAP similar genes for GCSAML Gene using alignment to 5 proteins:

  • GSAML_HUMAN
  • E7ESF0_HUMAN
  • E9PLW0_HUMAN
  • E9PR51_HUMAN
  • E9PRX8_HUMAN
genes like me logo Genes that share paralogs with GCSAML: view

No data available for Paralogs for GCSAML Gene

Variants for GCSAML Gene

Sequence variations from dbSNP and Humsavar for GCSAML Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000005905 -- 247,531,025(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000103261 -- 247,566,239(+) TTTATTTATTTATTTATTT/TTTATTTATTTATTT/TTTATTTATTTATTTATTTATTT intron_variant
rs1000125380 -- 247,521,393(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000196447 -- 247,554,026(+) C/T intron_variant
rs1000236980 -- 247,524,698(+) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GCSAML Gene

Variant ID Type Subtype PubMed ID
nsv945441 CNV duplication 23825009
nsv818889 CNV loss 17921354
nsv524193 CNV loss 19592680
nsv1006136 CNV loss 25217958
esv3589519 CNV loss 21293372
esv3589518 CNV loss 21293372
esv33129 CNV gain+loss 17666407
esv2759014 CNV gain+loss 17122850
esv2666510 CNV deletion 23128226

Variation tolerance for GCSAML Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GCSAML Gene

Human Gene Mutation Database (HGMD)
GCSAML
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GCSAML

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GCSAML Gene

Disorders for GCSAML Gene

Additional Disease Information for GCSAML

No disorders were found for GCSAML Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GCSAML Gene

Publications for GCSAML Gene

  1. Maternal 5mCpG Imprints at the PARD6G-AS1 and GCSAML Differentially Methylated Regions Are Decoupled From Parent-of-Origin Expression Effects in Multiple Human Tissues. (PMID: 29545821) de Sá Machado Araújo G … Medina-Acosta E (Frontiers in genetics 2018) 3 58
  2. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C … Soranzo N (Nature 2011) 3 58
  3. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PMID: 19684603) Treviño LR … Relling MV (Nature genetics 2009) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for GCSAML Gene

Sources for GCSAML Gene

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