Aliases for GCSAM Gene
External Ids for GCSAM Gene
Previous HGNC Symbols for GCSAM Gene
Previous GeneCards Identifiers for GCSAM Gene
This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for GCSAM Gene
GCSAM (Germinal Center Associated Signaling And Motility) is a Protein Coding gene. Diseases associated with GCSAM include Lymphoma and Diffuse Large B-Cell Lymphoma. Gene Ontology (GO) annotations related to this gene include protein kinase binding and myosin II binding. An important paralog of this gene is GCSAML.
UniProtKB/Swiss-Prot Summary for GCSAM Gene
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.