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Aliases for GCSAM Gene

Aliases for GCSAM Gene

  • Germinal Center Associated Signaling And Motility 2 3 5
  • Germinal Center B-Cell-Expressed Transcript 2 Protein 3 4
  • Germinal Center-Associated Lymphoma Protein 3 4
  • Human Germinal Center-Associated Lymphoma 2 3
  • Germinal Center Expressed Transcript 2 2 3
  • GCET2 3 4
  • HGAL 3 4
  • Germinal Center-Associated Signaling And Motility Protein 3
  • GCAT2 3
  • GAL 4

External Ids for GCSAM Gene

Previous HGNC Symbols for GCSAM Gene

  • GCET2

Previous GeneCards Identifiers for GCSAM Gene

  • GC03M111840

Summaries for GCSAM Gene

Entrez Gene Summary for GCSAM Gene

  • This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for GCSAM Gene

GCSAM (Germinal Center Associated Signaling And Motility) is a Protein Coding gene. Diseases associated with GCSAM include Lymphoma and Diffuse Large B-Cell Lymphoma. Gene Ontology (GO) annotations related to this gene include protein kinase binding and myosin II binding.

UniProtKB/Swiss-Prot for GCSAM Gene

  • Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.

Additional gene information for GCSAM Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCSAM Gene

Genomics for GCSAM Gene

GeneHancer (GH) Regulatory Elements for GCSAM Gene

Promoters and enhancers for GCSAM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I112124 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 550.4 +6.1 6140 11.6 HDGF PKNOX1 SMAD1 NSD2 MZF1 BMI1 BATF KLF5 IRF4 RFX5 GCSAM SLC9C1 ENSG00000261488 CD200 C3orf52 MIR567
GH03I112136 Enhancer 1.2 Ensembl ENCODE dbSUPER 550.8 -0.5 -454 1.4 HDGF PKNOX1 SMAD1 BMI1 RAD21 ZNF143 BCLAF1 IKZF2 RUNX3 DEK GCSAM SLC9C1 MIR567 C3orf52 CD200 LOC100420831
GH03I112112 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 24.4 +19.6 19578 9.2 HDGF PKNOX1 SMAD1 RB1 BMI1 BATF KLF5 IRF4 ZNF143 ATF7 GCSAM SLC9C1 ENSG00000261488 CD200 BTLA C3orf52 MIR567 GC03P112114
GH03I112083 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 6 +50.6 50642 4.5 HDGF PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 ZNF121 C3orf52 SLC9C1 ENSG00000261488 MIR567 ABHD10 GCSAM TMPRSS7
GH03I112148 Enhancer 0.3 ENCODE 0.4 -12.6 -12617 1.7 NFE2L2 MIR567 C3orf52 SLC9C1 GCSAM LOC100420831
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GCSAM on UCSC Golden Path with GeneCards custom track

Genomic Locations for GCSAM Gene

Genomic Locations for GCSAM Gene
chr3:112,120,841-112,136,705
(GRCh38/hg38)
Size:
15,865 bases
Orientation:
Minus strand
chr3:111,839,688-111,852,152
(GRCh37/hg19)

Genomic View for GCSAM Gene

Genes around GCSAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCSAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCSAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCSAM Gene

Proteins for GCSAM Gene

  • Protein details for GCSAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6F7-GCSAM_HUMAN
    Recommended name:
    Germinal center-associated signaling and motility protein
    Protein Accession:
    Q8N6F7
    Secondary Accessions:
    • C9JD17
    • C9JUG6

    Protein attributes for GCSAM Gene

    Size:
    178 amino acids
    Molecular mass:
    21005 Da
    Quaternary structure:
    • Interacts with ACTB and MYH2; the interaction with MYH2 is increased by IL6-induced phosphorylation. Interacts (via C-terminus) with ARHGEF11 (via DH domain). Interacts with ARHGEF12. Interacts with SYK; the interaction increases after B-cell receptor stimulation, resulting in enhanced SYK autophosphorylation and activity.

    Alternative splice isoforms for GCSAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GCSAM Gene

Post-translational modifications for GCSAM Gene

  • Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GCSAM Gene

Domains & Families for GCSAM Gene

Gene Families for GCSAM Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GCSAM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GCSAM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GCSAM: view

No data available for UniProtKB/Swiss-Prot for GCSAM Gene

Function for GCSAM Gene

Molecular function for GCSAM Gene

UniProtKB/Swiss-Prot Function:
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL4/interleukin-4.

Phenotypes From GWAS Catalog for GCSAM Gene

Gene Ontology (GO) - Molecular Function for GCSAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IPI 17823310
GO:0005515 protein binding IPI 20844236
GO:0019901 protein kinase binding IPI 23299888
GO:0045159 myosin II binding IPI 17823310
genes like me logo Genes that share ontologies with GCSAM: view
genes like me logo Genes that share phenotypes with GCSAM: view

Animal Models for GCSAM Gene

MGI Knock Outs for GCSAM:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GCSAM Gene

Localization for GCSAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCSAM Gene

Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GCSAM gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GCSAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GCSAM: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GCSAM Gene

Pathways & Interactions for GCSAM Gene

SuperPathways for GCSAM Gene

No Data Available

Interacting Proteins for GCSAM Gene

Gene Ontology (GO) - Biological Process for GCSAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050855 regulation of B cell receptor signaling pathway IMP,IEA 23299888
GO:2000401 regulation of lymphocyte migration IEA --
GO:2000402 negative regulation of lymphocyte migration IMP 17823310
genes like me logo Genes that share ontologies with GCSAM: view

No data available for Pathways by source and SIGNOR curated interactions for GCSAM Gene

Drugs & Compounds for GCSAM Gene

No Compound Related Data Available

Transcripts for GCSAM Gene

Unigene Clusters for GCSAM Gene

Germinal center-associated, signaling and motility:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GCSAM Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - - -
SP6:

Relevant External Links for GCSAM Gene

GeneLoc Exon Structure for
GCSAM
ECgene alternative splicing isoforms for
GCSAM

Expression for GCSAM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GCSAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GCSAM Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.1) and Skin - Not Sun Exposed (Suprapubic) (x4.9).

Protein differential expression in normal tissues from HIPED for GCSAM Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GCSAM Gene



Protein tissue co-expression partners for GCSAM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GCSAM Gene:

GCSAM

SOURCE GeneReport for Unigene cluster for GCSAM Gene:

Hs.49614

mRNA Expression by UniProt/SwissProt for GCSAM Gene:

Q8N6F7-GCSAM_HUMAN
Tissue specificity: Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen.

Evidence on tissue expression from TISSUES for GCSAM Gene

  • Lymph node(2.8)
genes like me logo Genes that share expression patterns with GCSAM: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GCSAM Gene

Orthologs for GCSAM Gene

This gene was present in the common ancestor of mammals.

Orthologs for GCSAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GCSAM 33 34
  • 99.24 (n)
cow
(Bos Taurus)
Mammalia LOC784939 33
  • 78.91 (n)
GCSAM 34
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GCSAM 33 34
  • 75.15 (n)
mouse
(Mus musculus)
Mammalia Gcsam 33 16 34
  • 70.48 (n)
rat
(Rattus norvegicus)
Mammalia Gcsam 33
  • 69.3 (n)
Species where no ortholog for GCSAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GCSAM Gene

ENSEMBL:
Gene Tree for GCSAM (if available)
TreeFam:
Gene Tree for GCSAM (if available)

Paralogs for GCSAM Gene

(1) SIMAP similar genes for GCSAM Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GCSAM: view

No data available for Paralogs for GCSAM Gene

Variants for GCSAM Gene

Sequence variations from dbSNP and Humsavar for GCSAM Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000493452 -- 112,128,752(-) A/G intron_variant
rs1000517943 -- 112,124,539(-) C/G intron_variant
rs1000624320 -- 112,134,111(-) C/T upstream_transcript_variant
rs1000627903 -- 112,125,876(-) A/T intron_variant
rs1000656944 -- 112,133,715(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GCSAM Gene

Variant ID Type Subtype PubMed ID
nsv480502 CNV novel sequence insertion 20440878
nsv481505 CNV novel sequence insertion 20440878

Variation tolerance for GCSAM Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GCSAM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GCSAM

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GCSAM Gene

Disorders for GCSAM Gene

MalaCards: The human disease database

(2) MalaCards diseases for GCSAM Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
diffuse large b-cell lymphoma
  • large b-cell diffuse lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search GCSAM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GCSAM

genes like me logo Genes that share disorders with GCSAM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GCSAM Gene

Publications for GCSAM Gene

  1. HGAL is a novel interleukin-4-inducible gene that strongly predicts survival in diffuse large B-cell lymphoma. (PMID: 12509382) Lossos IS … Levy R (Blood 2003) 3 4 22 58
  2. Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation. (PMID: 23299888) Romero-Camarero I … Lossos IS (Nature communications 2013) 3 4 58
  3. HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway. (PMID: 20844236) Jiang X … Lossos IS (Blood 2010) 3 4 58
  4. HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration. (PMID: 17823310) Lu X … Lossos IS (Blood 2007) 3 4 58
  5. Expression of the human germinal center-associated lymphoma (HGAL) protein, a new marker of germinal center B-cell derivation. (PMID: 15677569) Natkunam Y … Levy R (Blood 2005) 3 4 58

Products for GCSAM Gene

  • Addgene plasmids for GCSAM

Sources for GCSAM Gene

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