Aliases for GCNT7 Gene

Aliases for GCNT7 Gene

  • Glucosaminyl (N-Acetyl) Transferase Family Member 7 2 3 5
  • Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase 7 3 4
  • DJ1153D9.2 2 3
  • C20orf105 3 4
  • Beta 1,6-N-Acetylglucosaminyltransferase 3
  • Chromosome 20 Open Reading Frame 105 2
  • EC 2.4.1.150 51
  • EC 2.4.1.- 4
  • EC 2.4.1 51
  • GCNT7 5
  • Gcnt 3

External Ids for GCNT7 Gene

Previous HGNC Symbols for GCNT7 Gene

  • C20orf105

Previous GeneCards Identifiers for GCNT7 Gene

  • GC20U900290
  • GC20M054499
  • GC20M055066
  • GC20M051851

Summaries for GCNT7 Gene

GeneCards Summary for GCNT7 Gene

GCNT7 (Glucosaminyl (N-Acetyl) Transferase Family Member 7) is a Protein Coding gene. Diseases associated with GCNT7 include Croup. Among its related pathways are Metabolism of proteins and O-linked glycosylation. Gene Ontology (GO) annotations related to this gene include acetylglucosaminyltransferase activity. An important paralog of this gene is GCNT2.

UniProtKB/Swiss-Prot Summary for GCNT7 Gene

Additional gene information for GCNT7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GCNT7 Gene

Genomics for GCNT7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GCNT7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J056524 Promoter 0.4 EPDnew 600.7 +1.2 1200 0.1 CREB1 GCNT7 FAM209A RTF2 FAM210B ENSG00000280387 lnc-RTF2-1
GH20J056467 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.9 +57.0 57009 3 CREB1 GATAD2A ZNF629 TFE3 RFX1 SIX5 LEF1 SOX13 NFKBIZ POLR2A RTF2 lnc-GCNT7-1 CSTF1 GCNT7 AURKA RAE1 ENSG00000280387 SNODB1764 FAM209A
GH20J056390 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.8 +133.4 133424 4.2 CEBPG SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 SIX5 CSTF1 AURKA ENSG00000280387 GCNT7 RAE1 CASS4
GH20J057259 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.7 -737.0 -737048 8.5 GATAD2A ATF7 TEAD4 PRDM10 NFKBIZ ZNF692 ZNF7 JUND FOXA1 ZIC2 BMP7 ENSG00000226308 CSTF1 GCNT7 RAE1 ENSG00000280387 RBM38 LOC112268270 piR-53383 TFAP2C
GH20J056408 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.5 +108.8 108811 17 CEBPG GATAD2A YBX1 PRDM10 REST LEF1 IKZF1 ETV6 JUND GABPA CASS4 RTF2 CSTF1 RAE1 RPL39P ENSG00000280387 FAM210B GCNT7 FAM209B HSALNG0131068
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GCNT7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GCNT7

Top Transcription factor binding sites by QIAGEN in the GCNT7 gene promoter:
  • AhR
  • E47
  • Hand1
  • NRSF form 1
  • NRSF form 2
  • Olf-1
  • SRY

Genomic Locations for GCNT7 Gene

Genomic Locations for GCNT7 Gene
chr20:56,491,492-56,525,925
(GRCh38/hg38)
Size:
34,434 bases
Orientation:
Minus strand
chr20:55,066,548-55,100,981
(GRCh37/hg19)
Size:
34,434 bases
Orientation:
Minus strand

Genomic View for GCNT7 Gene

Genes around GCNT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCNT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCNT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCNT7 Gene

Proteins for GCNT7 Gene

  • Protein details for GCNT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNI0-GCNT7_HUMAN
    Recommended name:
    Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7
    Protein Accession:
    Q6ZNI0
    Secondary Accessions:
    • Q9HCV8

    Protein attributes for GCNT7 Gene

    Size:
    430 amino acids
    Molecular mass:
    49319 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GCNT7 Gene

Selected DME Specific Peptides for GCNT7 Gene

Q6ZNI0:
  • PPHNLTI
  • PQNVYCIH

Post-translational modifications for GCNT7 Gene

  • Glycosylation at Asn87 and Asn272
  • Modification sites at PhosphoSitePlus

Other Protein References for GCNT7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GCNT7 Gene

Gene Families for GCNT7 Gene

Protein Domains for GCNT7 Gene

InterPro:
Blocks:
  • Glycosyl transferase, family 14
ProtoNet:

Suggested Antigen Peptide Sequences for GCNT7 Gene

GenScript: Design optimal peptide antigens:
  • Beta 1,6-N-acetylglucosaminyltransferase (F2Z6J8_HUMAN)
  • Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7 (GCNT7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZNI0

UniProtKB/Swiss-Prot:

GCNT7_HUMAN :
  • Belongs to the glycosyltransferase 14 family.
Family:
  • Belongs to the glycosyltransferase 14 family.
genes like me logo Genes that share domains with GCNT7: view

Function for GCNT7 Gene

Molecular function for GCNT7 Gene

UniProtKB/Swiss-Prot Function:
Glycosyltransferase.

Enzyme Numbers (IUBMB) for GCNT7 Gene

Phenotypes From GWAS Catalog for GCNT7 Gene

Gene Ontology (GO) - Molecular Function for GCNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008375 acetylglucosaminyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with GCNT7: view

Phenotypes for GCNT7 Gene

genes like me logo Genes that share phenotypes with GCNT7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GCNT7

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GCNT7 Gene

Localization for GCNT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCNT7 Gene

Golgi apparatus membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GCNT7 gene
Compartment Confidence
golgi apparatus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for GCNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GCNT7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GCNT7 Gene

Pathways & Interactions for GCNT7 Gene

genes like me logo Genes that share pathways with GCNT7: view

UniProtKB/Swiss-Prot Q6ZNI0-GCNT7_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for GCNT7 Gene

Gene Ontology (GO) - Biological Process for GCNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
genes like me logo Genes that share ontologies with GCNT7: view

No data available for SIGNOR curated interactions for GCNT7 Gene

Drugs & Compounds for GCNT7 Gene

No Compound Related Data Available

Transcripts for GCNT7 Gene

mRNA/cDNA for GCNT7 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GCNT7

Alternative Splicing Database (ASD) splice patterns (SP) for GCNT7 Gene

No ASD Table

Relevant External Links for GCNT7 Gene

GeneLoc Exon Structure for
GCNT7

Expression for GCNT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GCNT7 Gene

mRNA differential expression in normal tissues according to GTEx for GCNT7 Gene

This gene is overexpressed in Whole Blood (x6.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GCNT7

SOURCE GeneReport for Unigene cluster for GCNT7 Gene:

Hs.655916
genes like me logo Genes that share expression patterns with GCNT7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GCNT7 Gene

Orthologs for GCNT7 Gene

This gene was present in the common ancestor of animals.

Orthologs for GCNT7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GCNT7 30 31
  • 98.99 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GCNT7 30 31
  • 83.99 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GCNT7 30 31
  • 83.37 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gcnt7 30 17 31
  • 76.1 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC102550196 30
  • 75.31 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia GCNT7 31
  • 51 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GCNT7 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GCNT7 30 31
  • 69.46 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GCNT7 31
  • 47 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gcnt7 30
  • 61.23 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101886707 30
  • 56.04 (n)
gcnt7 31
  • 39 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea gly-17 31
  • 18 (a)
ManyToMany
gly-16 31
  • 17 (a)
ManyToMany
gly-19 31
  • 16 (a)
ManyToMany
gly-18 31
  • 16 (a)
ManyToMany
gly-15 31
  • 15 (a)
ManyToMany
T14B4.9 31
  • 13 (a)
ManyToMany
gly-1 31
  • 13 (a)
ManyToMany
H41C03.3 31
  • 12 (a)
ManyToMany
R07C3.3 31
  • 12 (a)
ManyToMany
F26D2.3 31
  • 12 (a)
ManyToMany
ZK1225.2 31
  • 11 (a)
ManyToMany
F30A10.4 31
  • 11 (a)
ManyToMany
T09E11.9 31
  • 11 (a)
ManyToMany
T27F6.1 31
  • 11 (a)
ManyToMany
R07B7.6 31
  • 11 (a)
ManyToMany
T09E11.6 31
  • 10 (a)
ManyToMany
F35H8.2 31
  • 10 (a)
ManyToMany
T28F3.9 31
  • 9 (a)
ManyToMany
Y51H4A.25 31
  • 9 (a)
ManyToMany
Species where no ortholog for GCNT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GCNT7 Gene

ENSEMBL:
Gene Tree for GCNT7 (if available)
TreeFam:
Gene Tree for GCNT7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GCNT7: view image

Paralogs for GCNT7 Gene

Paralogs for GCNT7 Gene

(8) SIMAP similar genes for GCNT7 Gene using alignment to 1 proteins:

  • GCNT7_HUMAN
genes like me logo Genes that share paralogs with GCNT7: view

Variants for GCNT7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GCNT7 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs34552628 - p.Asp352Glu
rs3746627 - p.Asn425His

Structural Variations from Database of Genomic Variants (DGV) for GCNT7 Gene

Variant ID Type Subtype PubMed ID
esv2722575 CNV deletion 23290073
esv29810 CNV gain 19812545
nsv1056574 CNV gain 25217958
nsv525425 CNV gain 19592680
nsv834015 CNV loss 17160897

Variation tolerance for GCNT7 Gene

Gene Damage Index Score: 5.44; 71.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GCNT7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GCNT7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Additional dbSNP identifiers (rs#s) for GCNT7 Gene

Disorders for GCNT7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GCNT7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
croup
  • acute laryngotracheobronchitis
- elite association - COSMIC cancer census association via MalaCards
Search GCNT7 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with GCNT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GCNT7 Gene

Publications for GCNT7 Gene

  1. Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium. (PMID: 25367360) Li Q … CREAM Consortium (Human genetics 2015) 3
  2. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai DC … Hagoort P (Genes, brain, and behavior 2014) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 4

Products for GCNT7 Gene

Sources for GCNT7 Gene