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Aliases for GCNT7 Gene

Aliases for GCNT7 Gene

  • Glucosaminyl (N-Acetyl) Transferase Family Member 7 2 3 5
  • C20orf105 3 4
  • Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase 7 3
  • Beta 1,6-N-Acetylglucosaminyltransferase 3
  • Chromosome 20 Open Reading Frame 105 2
  • EC 2.4.1.150 56
  • DJ1153D9.2 3
  • EC 2.4.1.- 4
  • EC 2.4.1 56
  • Gcnt 3

External Ids for GCNT7 Gene

Previous HGNC Symbols for GCNT7 Gene

  • C20orf105

Previous GeneCards Identifiers for GCNT7 Gene

  • GC20U900290
  • GC20M054499
  • GC20M055066
  • GC20M051851

Summaries for GCNT7 Gene

GeneCards Summary for GCNT7 Gene

GCNT7 (Glucosaminyl (N-Acetyl) Transferase Family Member 7) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and O-linked glycosylation. Gene Ontology (GO) annotations related to this gene include acetylglucosaminyltransferase activity. An important paralog of this gene is GCNT2.

UniProtKB/Swiss-Prot for GCNT7 Gene

  • Glycosyltransferase.

Additional gene information for GCNT7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCNT7 Gene

Genomics for GCNT7 Gene

GeneHancer (GH) Regulatory Elements for GCNT7 Gene

Promoters and enhancers for GCNT7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I056524 Promoter 0.6 EPDnew 550.8 +1.2 1200 0.1 CREB1 FAM209B GCNT7 FAM209A RTF2 FAM210B GC20P056523
GH20I057439 Enhancer 1.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 13.9 -915.5 -915494 5.6 PKNOX1 NFIB NFXL1 BMI1 ZBTB7B RAD21 RFX5 YY1 ELK1 HSF1 RBM38 FAM209A GCNT7 LOC100291105 ENSG00000280387 PIR61563
GH20I056390 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12 +133.5 133491 3.8 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CSTF1 AURKA ENSG00000280387 GCNT7 CASS4
GH20I057409 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 13.9 -883.9 -883873 2.4 HDGF PKNOX1 SMAD1 ARNT NEUROD1 ZBTB7B POLR2B ZNF766 E2F8 ZNF207 ENSG00000280387 FAM209A GCNT7 PPP4R1L RBM38 CTCFL ZBP1 LOC100291105 PIR61563
GH20I057038 Enhancer 0.8 ENCODE 22.7 -513.1 -513075 0.2 HDGF PKNOX1 NFIB ZNF133 NEUROD1 BMI1 ZBTB7B TCF12 ZNF366 ZNF207 CSTF1 FAM209A ENSG00000280387 GCNT7 RAE1 LOC105372683 ENSG00000231078
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GCNT7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GCNT7 gene promoter:

Genomic Locations for GCNT7 Gene

Genomic Locations for GCNT7 Gene
chr20:56,491,492-56,525,925
(GRCh38/hg38)
Size:
34,434 bases
Orientation:
Minus strand
chr20:55,066,548-55,100,981
(GRCh37/hg19)

Genomic View for GCNT7 Gene

Genes around GCNT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCNT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCNT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCNT7 Gene

Proteins for GCNT7 Gene

  • Protein details for GCNT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNI0-GCNT7_HUMAN
    Recommended name:
    Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7
    Protein Accession:
    Q6ZNI0
    Secondary Accessions:
    • Q9HCV8

    Protein attributes for GCNT7 Gene

    Size:
    430 amino acids
    Molecular mass:
    49319 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAC03741.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAC03741.2; Type=Erroneous termination; Positions=65; Note=Translated as Gln.; Evidence={ECO:0000305};

neXtProt entry for GCNT7 Gene

Selected DME Specific Peptides for GCNT7 Gene

Q6ZNI0:
  • PPHNLTI
  • PQNVYCIH

Post-translational modifications for GCNT7 Gene

  • Glycosylation at posLast=8787 and posLast=272272
  • Modification sites at PhosphoSitePlus

Other Protein References for GCNT7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GCNT7 Gene

Gene Families for GCNT7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for GCNT7 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZNI0

UniProtKB/Swiss-Prot:

GCNT7_HUMAN :
  • Belongs to the glycosyltransferase 14 family.
Family:
  • Belongs to the glycosyltransferase 14 family.
genes like me logo Genes that share domains with GCNT7: view

Function for GCNT7 Gene

Molecular function for GCNT7 Gene

UniProtKB/Swiss-Prot Function:
Glycosyltransferase.

Enzyme Numbers (IUBMB) for GCNT7 Gene

Phenotypes From GWAS Catalog for GCNT7 Gene

Gene Ontology (GO) - Molecular Function for GCNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008375 acetylglucosaminyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with GCNT7: view

Phenotypes for GCNT7 Gene

GenomeRNAi human phenotypes for GCNT7:
genes like me logo Genes that share phenotypes with GCNT7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GCNT7 Gene

Localization for GCNT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCNT7 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GCNT7 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GCNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GCNT7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GCNT7 Gene

Pathways & Interactions for GCNT7 Gene

genes like me logo Genes that share pathways with GCNT7: view

UniProtKB/Swiss-Prot Q6ZNI0-GCNT7_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for GCNT7 Gene

Gene Ontology (GO) - Biological Process for GCNT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
genes like me logo Genes that share ontologies with GCNT7: view

No data available for SIGNOR curated interactions for GCNT7 Gene

Drugs & Compounds for GCNT7 Gene

No Compound Related Data Available

Transcripts for GCNT7 Gene

mRNA/cDNA for GCNT7 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GCNT7 Gene

Glucosaminyl (N-acetyl) transferase family member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GCNT7 Gene

No ASD Table

Relevant External Links for GCNT7 Gene

GeneLoc Exon Structure for
GCNT7
ECgene alternative splicing isoforms for
GCNT7

Expression for GCNT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GCNT7 Gene

mRNA differential expression in normal tissues according to GTEx for GCNT7 Gene

This gene is overexpressed in Whole Blood (x6.0).

NURSA nuclear receptor signaling pathways regulating expression of GCNT7 Gene:

GCNT7

SOURCE GeneReport for Unigene cluster for GCNT7 Gene:

Hs.655916
genes like me logo Genes that share expression patterns with GCNT7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GCNT7 Gene

Orthologs for GCNT7 Gene

This gene was present in the common ancestor of animals.

Orthologs for GCNT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GCNT7 33 34
  • 98.99 (n)
cow
(Bos Taurus)
Mammalia GCNT7 33 34
  • 83.99 (n)
dog
(Canis familiaris)
Mammalia GCNT7 34 33
  • 83.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gcnt7 16 34 33
  • 76.1 (n)
rat
(Rattus norvegicus)
Mammalia LOC102550196 33
  • 75.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GCNT7 34
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GCNT7 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves GCNT7 33 34
  • 69.46 (n)
lizard
(Anolis carolinensis)
Reptilia GCNT7 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gcnt7 33
  • 61.23 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101886707 33
  • 56.04 (n)
gcnt7 34
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gly-17 34
  • 18 (a)
ManyToMany
gly-16 34
  • 17 (a)
ManyToMany
gly-18 34
  • 16 (a)
ManyToMany
gly-19 34
  • 16 (a)
ManyToMany
gly-15 34
  • 15 (a)
ManyToMany
gly-1 34
  • 13 (a)
ManyToMany
T14B4.9 34
  • 13 (a)
ManyToMany
F26D2.3 34
  • 12 (a)
ManyToMany
H41C03.3 34
  • 12 (a)
ManyToMany
R07C3.3 34
  • 12 (a)
ManyToMany
F30A10.4 34
  • 11 (a)
ManyToMany
R07B7.6 34
  • 11 (a)
ManyToMany
T09E11.9 34
  • 11 (a)
ManyToMany
T27F6.1 34
  • 11 (a)
ManyToMany
ZK1225.2 34
  • 11 (a)
ManyToMany
F35H8.2 34
  • 10 (a)
ManyToMany
T09E11.6 34
  • 10 (a)
ManyToMany
T28F3.9 34
  • 9 (a)
ManyToMany
Y51H4A.25 34
  • 9 (a)
ManyToMany
Species where no ortholog for GCNT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GCNT7 Gene

ENSEMBL:
Gene Tree for GCNT7 (if available)
TreeFam:
Gene Tree for GCNT7 (if available)

Paralogs for GCNT7 Gene

Paralogs for GCNT7 Gene

(8) SIMAP similar genes for GCNT7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GCNT7: view

Variants for GCNT7 Gene

Sequence variations from dbSNP and Humsavar for GCNT7 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000002174 -- 56,527,567(-) C/T upstream_transcript_variant
rs1000143480 -- 56,492,244(-) A/G intron_variant
rs1000161665 -- 56,526,733(-) G/A upstream_transcript_variant
rs1000280797 -- 56,522,496(-) C/T intron_variant
rs1000319060 -- 56,512,968(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GCNT7 Gene

Variant ID Type Subtype PubMed ID
esv2722575 CNV deletion 23290073
esv29810 CNV gain 19812545
nsv1056574 CNV gain 25217958
nsv525425 CNV gain 19592680
nsv834015 CNV loss 17160897

Variation tolerance for GCNT7 Gene

Gene Damage Index Score: 5.44; 71.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GCNT7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GCNT7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GCNT7 Gene

Disorders for GCNT7 Gene

Additional Disease Information for GCNT7

No disorders were found for GCNT7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GCNT7 Gene

Publications for GCNT7 Gene

  1. Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium. (PMID: 25367360) Li Q … CREAM Consortium (Human genetics 2015) 3 58
  2. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai DC … Hagoort P (Genes, brain, and behavior 2014) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 4 58

Products for GCNT7 Gene

Sources for GCNT7 Gene

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