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Aliases for GCNA Gene

Aliases for GCNA Gene

  • Germ Cell Nuclear Acidic Peptidase 2 3 5
  • Germ Cell Nuclear Antigen 3 4
  • Acidic Repeat Containing 2 3
  • ACRC 3 4
  • Acidic Repeat-Containing Protein 3
  • Putative Nuclear Protein 3
  • NAAR1 3

External Ids for GCNA Gene

Previous HGNC Symbols for GCNA Gene

  • ACRC

Summaries for GCNA Gene

GeneCards Summary for GCNA Gene

GCNA (Germ Cell Nuclear Acidic Peptidase) is a Protein Coding gene. Diseases associated with GCNA include Appendix Adenocarcinoma.

Gene Wiki entry for GCNA Gene

Additional gene information for GCNA Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCNA Gene

Genomics for GCNA Gene

GeneHancer (GH) Regulatory Elements for GCNA Gene

Promoters and enhancers for GCNA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI071578 Promoter 0.7 EPDnew 550.8 +0.4 394 0.1 POLR2A ZBTB33 GCNA CXCR3
GH0XI071579 Enhancer 0.6 ENCODE 550.8 +1.8 1802 0.2 ZNF10 SP2 REST ZNF398 ZNF148 ZFHX2 KLF16 ZNF184 EGR1 TRIM24 GCNA CXCR3
GH0XI071530 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 15 -44.3 -44279 5.7 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A OGT TAF1 NONO MED12 ERCC6L GCNA LOC100420758 ENSG00000229601 RPS26P11 ZMYM3
GH0XI070930 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 14.7 -647.0 -647008 1.4 ZNF473 L3MBTL2 POLR2A SCRT2 ZSCAN4 SIN3A SLC7A3 GCNA CXorf65 TEX11
GH0XI071605 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 13.4 +28.8 28791 2.2 ZNF687 ZNF316 NFE2 EMSY GCNA CXCR3 IL2RG TAF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GCNA on UCSC Golden Path with GeneCards custom track

Genomic Locations for GCNA Gene

Genomic Locations for GCNA Gene
35,560 bases
Plus strand

Genomic View for GCNA Gene

Genes around GCNA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCNA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCNA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCNA Gene

Proteins for GCNA Gene

  • Protein details for GCNA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acidic repeat-containing protein
    Protein Accession:
    Secondary Accessions:
    • B9EG62

    Protein attributes for GCNA Gene

    691 amino acids
    Molecular mass:
    76112 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GCNA Gene

Post-translational modifications for GCNA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GCNA Gene

No data available for DME Specific Peptides for GCNA Gene

Domains & Families for GCNA Gene

Gene Families for GCNA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GCNA Gene


Suggested Antigen Peptide Sequences for GCNA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serine-aspartate repeat-containing protein (SDr) family.
  • Belongs to the serine-aspartate repeat-containing protein (SDr) family.
genes like me logo Genes that share domains with GCNA: view

Function for GCNA Gene

genes like me logo Genes that share phenotypes with GCNA: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GCNA Gene

Localization for GCNA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCNA Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GCNA gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GCNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 27718356
genes like me logo Genes that share ontologies with GCNA: view

Pathways & Interactions for GCNA Gene

No Data Available

Interacting Proteins for GCNA Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000362799 for GCNA Gene via STRING

Gene Ontology (GO) - Biological Process for GCNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0080111 DNA demethylation IBA --
genes like me logo Genes that share ontologies with GCNA: view

No data available for Pathways by source and SIGNOR curated interactions for GCNA Gene

Drugs & Compounds for GCNA Gene

No Compound Related Data Available

Transcripts for GCNA Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GCNA Gene

No ASD Table

Relevant External Links for GCNA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GCNA Gene

NURSA nuclear receptor signaling pathways regulating expression of GCNA Gene:


mRNA Expression by UniProt/SwissProt for GCNA Gene:

Tissue specificity: Expressed in germ cells of the testis (at protein level) (PubMed:27718356). Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain (PubMed:11714101).

Evidence on tissue expression from TISSUES for GCNA Gene

  • Heart(4.1)
  • Lung(4.1)
  • Nervous system(4.1)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GCNA Gene

Orthologs for GCNA Gene

This gene was present in the common ancestor of animals.

Orthologs for GCNA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACRC 34
  • 97 (a)
(Canis familiaris)
Mammalia ACRC 34
  • 47 (a)
(Monodelphis domestica)
Mammalia ACRC 34
  • 30 (a)
(Gallus gallus)
Aves ACRC 34
  • 27 (a)
(Anolis carolinensis)
Reptilia ACRC 34
  • 37 (a)
(Danio rerio)
Actinopterygii acrc 34
  • 23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14814 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea ZK328.4 34
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5183 34
  • 31 (a)
Species where no ortholog for GCNA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GCNA Gene

Gene Tree for GCNA (if available)
Gene Tree for GCNA (if available)

Paralogs for GCNA Gene Pseudogenes for GCNA Gene

genes like me logo Genes that share paralogs with GCNA: view

No data available for Paralogs for GCNA Gene

Variants for GCNA Gene

Sequence variations from dbSNP and Humsavar for GCNA Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000167614 -- 71,593,174(+) G/A intron_variant
rs1000545918 -- 71,596,569(+) T/C intron_variant
rs1000605059 -- 71,577,783(+) TTTTTTT/TTTTTTTT upstream_transcript_variant
rs1000681564 -- 71,597,479(+) G/A intron_variant
rs1000687217 -- 71,581,225(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GCNA Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv27144 CNV gain 19812545
esv2740214 CNV deletion 23290073
esv33082 CNV loss 17666407
nsv6954 CNV insertion 18451855

Variation tolerance for GCNA Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GCNA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GCNA Gene

Disorders for GCNA Gene

MalaCards: The human disease database

(1) MalaCards diseases for GCNA Gene - From: DISEASES

Disorder Aliases PubMed IDs
appendix adenocarcinoma
  • adenocarcinoma of appendix
- elite association - COSMIC cancer census association via MalaCards
Search GCNA in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with GCNA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GCNA Gene

Publications for GCNA Gene

  1. A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. (PMID: 27718356) Carmell MA … Page DC (eLife 2016) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. ACRC codes for a novel nuclear protein with unusual acidic repeat tract and maps to DYT3 (dystonia parkinsonism) critical interval in xq13.1. (PMID: 11714101) Nolte D … Müller U (Neurogenetics 2001) 3 4 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for GCNA Gene

Sources for GCNA Gene

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