Aliases for GCNA Gene

Aliases for GCNA Gene

  • Germ Cell Nuclear Acidic Peptidase 2 3 5
  • Acidic Repeat-Containing Protein 3 4
  • Germ Cell Nuclear Antigen 3 4
  • Acidic Repeat Containing 2 3
  • ACRC 3 4
  • Putative Nuclear Protein 3
  • NAAR1 3

External Ids for GCNA Gene

Previous HGNC Symbols for GCNA Gene

  • ACRC

Summaries for GCNA Gene

GeneCards Summary for GCNA Gene

GCNA (Germ Cell Nuclear Acidic Peptidase) is a Protein Coding gene. Diseases associated with GCNA include Appendix Adenocarcinoma and Cribriform Carcinoma.

Gene Wiki entry for GCNA Gene

Additional gene information for GCNA Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GCNA Gene

Genomics for GCNA Gene

GeneHancer (GH) Regulatory Elements for GCNA Gene

Promoters and enhancers for GCNA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ071579 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 500.7 +1.7 1677 1.4 ZNF10 REST ZNF148 SP2 POLR2G ZFHX2 EGR1 ZNF398 ZBTB33 AGO2 GCNA OGT lnc-CXCR3-9 RF00017-8514
GH0XJ071578 Promoter 0.6 EPDnew 500.7 +0.4 394 0.1 POLR2A POLR2G ZBTB33 AGO2 GCNA lnc-CXCR3-9 RF00017-8514
GH0XJ071530 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 15 -43.7 -43679 6.9 FOXK2 ZBTB40 EP300 ZSCAN5C SIN3A NRF1 TCF12 MYC POLR2G SP1 OGT lnc-OGT-1 GCNA TAF1 ZMYM3 RTL5 piR-56480-054 RF00017-8514
GH0XJ070929 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 14.7 -647.4 -647424 2.8 SAP30 HDAC2 RBM25 POLR2A PHF8 SIN3A TAF1 GTF2F1 L3MBTL2 TBP SLC7A3 GCNA MED12 IL2RG CXorf65 lnc-FOXO4-1
GH0XJ071606 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 13.4 +29.3 29277 4.6 CTCF RBM25 ZNF316 SPI1 NFE2 BCOR NR2F1 NR2F6 ZMYM3 ZNF280D GCNA CXCR3 IL2RG TAF1 lnc-CXCR3-9 RF00017-8514
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GCNA on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GCNA

Genomic Locations for GCNA Gene

Genomic Locations for GCNA Gene
35,560 bases
Plus strand
35,560 bases
Plus strand

Genomic View for GCNA Gene

Genes around GCNA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCNA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCNA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCNA Gene

Proteins for GCNA Gene

  • Protein details for GCNA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acidic repeat-containing protein
    Protein Accession:
    Secondary Accessions:
    • B9EG62

    Protein attributes for GCNA Gene

    691 amino acids
    Molecular mass:
    76112 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GCNA Gene

Post-translational modifications for GCNA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GCNA Gene

No data available for DME Specific Peptides for GCNA Gene

Domains & Families for GCNA Gene

Gene Families for GCNA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GCNA Gene


Suggested Antigen Peptide Sequences for GCNA Gene

GenScript: Design optimal peptide antigens:
  • Acidic repeat-containing protein (ACRC_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the serine-aspartate repeat-containing protein (SDr) family.
  • Belongs to the serine-aspartate repeat-containing protein (SDr) family.
genes like me logo Genes that share domains with GCNA: view

Function for GCNA Gene

genes like me logo Genes that share phenotypes with GCNA: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GCNA Gene

Localization for GCNA Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCNA Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GCNA gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GCNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 27718356
genes like me logo Genes that share ontologies with GCNA: view

Pathways & Interactions for GCNA Gene

PathCards logo

SuperPathways for GCNA Gene

No Data Available

Interacting Proteins for GCNA Gene


Gene Ontology (GO) - Biological Process for GCNA Gene


No data available for Pathways by source and SIGNOR curated interactions for GCNA Gene

Drugs & Compounds for GCNA Gene

No Compound Related Data Available

Transcripts for GCNA Gene

mRNA/cDNA for GCNA Gene

5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GCNA Gene

No ASD Table

Relevant External Links for GCNA Gene

GeneLoc Exon Structure for

Expression for GCNA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GCNA

mRNA Expression by UniProt/SwissProt for GCNA Gene:

Tissue specificity: Expressed in germ cells of the testis (at protein level) (PubMed:27718356). Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain (PubMed:11714101).

Evidence on tissue expression from TISSUES for GCNA Gene

  • Heart(4.1)
  • Lung(4.1)
  • Nervous system(4.1)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GCNA Gene

Orthologs for GCNA Gene

This gene was present in the common ancestor of animals.

Orthologs for GCNA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACRC 31
  • 97 (a)
(Canis familiaris)
Mammalia ACRC 31
  • 47 (a)
(Monodelphis domestica)
Mammalia ACRC 31
  • 30 (a)
(Gallus gallus)
Aves ACRC 31
  • 27 (a)
(Anolis carolinensis)
Reptilia ACRC 31
  • 37 (a)
(Danio rerio)
Actinopterygii acrc 31
  • 23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14814 31
  • 14 (a)
(Caenorhabditis elegans)
Secernentea ZK328.4 31
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5183 31
  • 31 (a)
Species where no ortholog for GCNA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GCNA Gene

Gene Tree for GCNA (if available)
Gene Tree for GCNA (if available)
Evolutionary constrained regions (ECRs) for GCNA: view image

Paralogs for GCNA Gene Pseudogenes for GCNA Gene

genes like me logo Genes that share paralogs with GCNA: view

No data available for Paralogs for GCNA Gene

Variants for GCNA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GCNA Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs10217999 - p.Arg471His
rs2280962 - p.Thr662Ile

Additional dbSNP identifiers (rs#s) for GCNA Gene

Structural Variations from Database of Genomic Variants (DGV) for GCNA Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv27144 CNV gain 19812545
esv2740214 CNV deletion 23290073
esv33082 CNV loss 17666407
nsv6954 CNV insertion 18451855

Variation tolerance for GCNA Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GCNA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GCNA Gene

Disorders for GCNA Gene

MalaCards: The human disease database

(2) MalaCards diseases for GCNA Gene - From: DISEASES

Disorder Aliases PubMed IDs
appendix adenocarcinoma
  • mucinous adenocarcinoma
cribriform carcinoma
  • ductal carcinoma, cribriform type
- elite association - COSMIC cancer census association via MalaCards
Search GCNA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GCNA

genes like me logo Genes that share disorders with GCNA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GCNA Gene

Publications for GCNA Gene

  1. A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. (PMID: 27718356) Carmell MA … Page DC (eLife 2016) 2 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. ACRC codes for a novel nuclear protein with unusual acidic repeat tract and maps to DYT3 (dystonia parkinsonism) critical interval in xq13.1. (PMID: 11714101) Nolte D … Müller U (Neurogenetics 2001) 3 4 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54

Products for GCNA Gene

Sources for GCNA Gene