Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided... See more...
Aliases for GCM1 Gene
Aliases for GCM1 Gene
External Ids for GCM1 Gene
- HGNC: 4197
- Entrez Gene: 8521
- Ensembl: ENSG00000137270
- OMIM: 603715
- UniProtKB: Q9NP62
Previous HGNC Symbols for GCM1 Gene
- GCMA
Previous GeneCards Identifiers for GCM1 Gene
- GC06M052993
- GC06M053039
- GC06M052991
- GC06M052823
Summaries for GCM1 Gene
-
This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for GCM1 Gene
GCM1 (Glial Cells Missing Transcription Factor 1) is a Protein Coding gene. Diseases associated with GCM1 include Pre-Eclampsia and Placenta Disease. Among its related pathways are Parathyroid hormone synthesis, secretion and action and Human Early Embryo Development. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is GCM2.
UniProtKB/Swiss-Prot Summary for GCM1 Gene
-
Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068).
Additional gene information for GCM1 Gene
- Monarch Initiative
- Search for GCM1 at DataMed
- Search for GCM1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GCM1 Gene
Genomics for GCM1 Gene
GeneHancer (GH) Regulatory Elements for GCM1 Gene
Promoters and enhancers for GCM1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J053148 | Promoter | 0.6 | EPDnew | 500.7 | 0.0 | -9 | 0.1 | NFIC ZNF189 NFIA | GCM1 RF00012-042 RF00026-938 RNU6-464P | |
| GH06J053147 | Promoter | 0.4 | EPDnew | 500.7 | +0.9 | 890 | 0.1 | CBX8 | GCM1 RF00012-042 | |
| GH06J053119 | Enhancer | 1.1 | Ensembl ENCODE | 12.3 | +29.1 | 29140 | 2.6 | NCOR1 FOS KDM6A TCF7 RFX1 ZBTB25 TGIF2 SKI TEAD1 TBX3 | GCM1 RNU6-464P ENSG00000218713 CILK1 ENSG00000261745 piR-59394 | |
| GH06J053213 | Enhancer | 0.6 | Ensembl dbSUPER | 12.9 | -69.4 | -69359 | 8 | SPI1 ELF1 GATA3 NCOA3 | RF00003-076 RNU1-136P ENSG00000218713 GCM1 piR-35674-450 | |
| GH06J053180 | Enhancer | 0.9 | Ensembl dbSUPER | 4.6 | -31.0 | -30960 | 3.2 | ZBTB40 ZNF300 ZNF662 ZNF491 CREB1 ZNF195 NFIC ZNF263 ZNF184 GATA3 | EFHC1 MCM3 ENSG00000218713 GCM1 HSALNG0050654 RF00026-938 RNU6-464P |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GCM1 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GCM1
- Top Transcription factor binding sites by QIAGEN in the GCM1 gene promoter:
-
- aMEF-2
- AML1a
- AREB6
- ATF6
- GATA-1
- MEF-2A
- Pbx1a
- RORalpha1
- ZID
Genomic Locations for GCM1 Gene
Genomic Locations for GCM1 Gene
- chr6:53,126,961-53,148,841
- (GRCh38/hg38)
- Size:
- 21,881 bases
- Orientation:
- Minus strand
- chr6:52,991,759-53,013,627
- (GRCh37/hg19)
- Size:
- 21,869 bases
- Orientation:
- Minus strand
Genomic View for GCM1 Gene
Genes around GCM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.1 by HGNC
- 6p12.1 by Entrez Gene
- 6p12.1 by Ensembl
GCM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GCM1 Gene
Proteins for GCM1 Gene
-
Protein details for GCM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NP62-GCM1_HUMAN
- Recommended name:
- Chorion-specific transcription factor GCMa
- Protein Accession:
- Q9NP62
- Q4VAQ7
- Q5T0X0
- Q99468
- Q9P1X3
Protein attributes for GCM1 Gene
- Size:
- 436 amino acids
- Molecular mass:
- 49268 Da
- Quaternary structure:
- No Data Available
Protein Expression for GCM1 Gene
Post-translational modifications for GCM1 Gene
- Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for GCM1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-GCM1 monoclonal antibody, clone 3F22
-
Custom Antibody ServicesOriGene Antibodies for GCM1
- Novus Biologicals Antibodies for GCM1
-
Abcam antibodies for GCM1
- Invitrogen Antibodies for GCM1 (AFLGC-GCM1)
-
Biorbyt antibodies for GCM1
-
Santa Cruz Biotechnology (SCBT) Antibodies for GCM1
Protein Products
-
OriGene Purified Proteins for GCM1
- Search Origene for MassSpec and Protein Over-expression Lysates for GCM1
- Origene Custom Protein Services for GCM1
- antibodies-online: Show 3 available GCM1 Proteins ranked by validation data
- Compare Top GCM1 Proteins
-
Quality Products:
No data available for DME Specific Peptides for GCM1 Gene
Domains & Families for GCM1 Gene
Gene Families for GCM1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for GCM1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GCM1 Gene
- GenScript: Design optimal peptide antigens:
-
- Glial cells missing homolog 1 (GCM1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GCM1 Gene
Function for GCM1 Gene
Molecular function for GCM1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068).
Phenotypes From GWAS Catalog for GCM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 15385555 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS,IDA | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 15385555 |
| GO:0003677 | DNA binding | TAS | 8962155 |
| GO:0003700 | DNA-binding transcription factor activity | IDA | 15385555 |
Phenotypes for GCM1 Gene
- MGI mutant phenotypes for GCM1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for GCM1:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Reduced mammosphere formation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
Animal Models for GCM1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GCM1 - Select products 50% OFF >
- * GCM1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GCM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GCM1
- genomics-online: gRNA clones - Search for available GCM1 gRNA products
- Overview of 98 available GCM1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for GCM1
miRNA for GCM1 Gene
- miRTarBase miRNAs that target GCM1
-
- hsa-mir-19b-3p (MIRT007272)
- hsa-mir-515-5p (MIRT734889)
- hsa-mir-1247-3p (MIRT736379)
- hsa-mir-1273f (MIRT736799)
- hsa-mir-1827 (MIRT738105)
- hsa-mir-1910-3p (MIRT738409)
- hsa-mir-2467-3p (MIRT739266)
- hsa-mir-3612 (MIRT741571)
- hsa-mir-377-5p (MIRT742681)
- hsa-mir-4252 (MIRT743331)
- hsa-mir-4257 (MIRT743405)
- hsa-mir-4537 (MIRT746087)
- hsa-mir-455-3p (MIRT746175)
- hsa-mir-566 (MIRT751118)
- hsa-mir-6086 (MIRT751835)
- hsa-mir-6499-3p (MIRT752792)
- hsa-mir-650 (MIRT753019)
- hsa-mir-6511a-5p (MIRT753134)
- hsa-mir-6516-5p (MIRT753338)
- hsa-mir-652-3p (MIRT753411)
- hsa-mir-6715a-3p (MIRT753677)
- hsa-mir-6715b-3p (MIRT753681)
- hsa-mir-6789-3p (MIRT756007)
- hsa-mir-371a-5p (MIRT767168)
- hsa-mir-888-5p (MIRT782590)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GCM1
- Browse OriGene Inhibitory RNA Products For GCM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GCM1
- genomics-online: shRNA clones - Search for available GCM1 shRNA products
- Overview of 98 available GCM1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for GCM1 - Select products 50% OFF >
- * GCM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GCM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GCM1
- genomics-online: cdna clones - Search for available GCM1 CDNA products
- Overview of 98 available GCM1 gene related products
- orf clones - Search for available GCM1 ORF products
- Overview of 98 available GCM1 gene related products
Cell Line Products
-
Horizon Cell Lines for GCM1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GCM1 Gene
Localization for GCM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GCM1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | TAS,IDA | 23867755 |
| GO:0005667 | transcription factor complex | IDA | 15385555 |
Pathways & Interactions for GCM1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Parathyroid hormone synthesis, secretion and action | ||
| 2 | Human Early Embryo Development |
Human Early Embryo Development
-
|
|
Pathways by source for GCM1 Gene
1 KEGG pathway for GCM1 Gene
1 Qiagen pathway for GCM1 Gene
- Human Early Embryo Development
Interacting Proteins for GCM1 Gene
Selected Interacting proteins:
Q9NP62-GCM1_HUMAN
ENSP00000259803
for GCM1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for GCM1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 15385555 |
| GO:0006366 | transcription by RNA polymerase II | IDA | 23867755 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009653 | anatomical structure morphogenesis | TAS | 8962155 |
| GO:0042063 | gliogenesis | IBA | 21873635 |
No data available for SIGNOR curated interactions for GCM1 Gene
Transcripts for GCM1 Gene
mRNA/cDNA for GCM1 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000259803 2780 bps (ENST00000259803.8)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GCM1 - Select products 50% OFF >
- * GCM1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GCM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GCM1
- genomics-online: gRNA clones - Search for available GCM1 gRNA products
- Overview of 98 available GCM1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for GCM1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GCM1
- Browse OriGene Inhibitory RNA Products For GCM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GCM1
- genomics-online: shRNA clones - Search for available GCM1 shRNA products
- Overview of 98 available GCM1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for GCM1 - Select products 50% OFF >
- * GCM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GCM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GCM1
- genomics-online: cdna clones - Search for available GCM1 CDNA products
- Overview of 98 available GCM1 gene related products
- orf clones - Search for available GCM1 ORF products
- Overview of 98 available GCM1 gene related products
Relevant External Links for GCM1 Gene
- GeneLoc Exon Structure for
- GCM1
Expression for GCM1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
- Hematopoietic Bone Marrow
-
Trophoblast (Extraembryonic Tissues)
- Mural Trophectoderm Cells Mural Trophectoderm
- Ovary (Reproductive System)
- NULL (Uncategorized)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for GCM1 Gene
This gene is overexpressed in Whole Blood (x20.6), Testis (x6.3), and Kidney - Cortex (x5.6).
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GCM1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GCM1
SOURCE GeneReport for Unigene cluster for GCM1 Gene:
Hs.28346mRNA Expression by UniProt/SwissProt for GCM1 Gene:
Q9NP62-GCM1_HUMAN
Tissue specificity:
Highly expressed in the placenta (PubMed:10542267). Expressed in trophoblast cells of the villi (PubMed:27917469).
Evidence on tissue expression from TISSUES for GCM1 Gene
- Liver(4)
Primer Products
-
OriGene qPCR primer pairs for GCM1
- genomics-online: primer clones - Search for available GCM1 Primer products
- Overview of 98 available GCM1 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GCM1 Gene
Orthologs for GCM1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GCM1 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GCM1 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gcm1 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gcm1 30 |
|
||
| cow (Bos Taurus) |
Mammalia | GCM-1 31 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GCM1 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GCM1 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GCM1 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GCM1 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gcm1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16562 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007782 30 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | gcm 31 |
|
ManyToMany | |
| gcm2 31 |
|
ManyToMany |
- Species where no ortholog for GCM1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for GCM1 Gene
- ENSEMBL:
- Gene Tree for GCM1 (if available)
- TreeFam:
- Gene Tree for GCM1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GCM1: view image
Paralogs for GCM1 Gene
(1) SIMAP similar genes for GCM1 Gene using alignment to 1 proteins:
- GCM1_HUMAN
Pseudogenes.org Pseudogenes for GCM1 Gene
Variants for GCM1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1124063 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.29;
25.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GCM1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GCM1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GCM1 Gene
Disorders for GCM1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pre-eclampsia |
|
|
| placenta disease |
|
|
| gestational choriocarcinoma |
|
|
| persistent fetal circulation syndrome |
|
|
Search GCM1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GCM1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GCM1 Gene
Publications for GCM1 Gene
- Parallel genotyping of 10,204 single nucleotide polymorphisms to screen for susceptible genes for IgA nephropathy. (PMID: 19890582) Woo KT … Chan CM (Annals of the Academy of Medicine, Singapore 2009) 3 23 41 54
- Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. (PMID: 18703417) Chiang MH … Chen H (Biology of reproduction 2008) 3 4 23 54
- Glial cell missing 1 regulates placental growth factor (PGF) gene transcription in human trophoblast. (PMID: 18160678) Chang M … Torry DS (Biology of reproduction 2008) 3 4 23 54
- Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene. (PMID: 11071865) Yamada K … Okazaki T (Biochemical and biophysical research communications 2000) 3 4 23 54
- The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals. (PMID: 8962155) Akiyama Y … Hotta Y (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 54
ExternalLinks
Products for GCM1 Gene
- Custom Antibody ServicesOriGene Antibodies for GCM1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GCM1
- Search Origene for MassSpec and Protein Over-expression Lysates for GCM1
- Origene Custom Protein Services for GCM1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GCM1
- Browse OriGene Inhibitory RNA Products For GCM1
- OriGene qPCR primer pairs for GCM1
- OriGene CRISPR knockouts for GCM1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GCM1
- Sino Biological Human cDNA Clone for GCM1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GCM1
- Novus Biologicals proteins and lysates for GCM1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for GCM1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for GCM1 (AFLGC-GCM1)
- VectorBuilder Custom and pre-made DNA vectors for GCM1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GCM1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GCM1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GCM1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GCM1
- antibodies-online: Show 13 available GCM1 Antibodies ranked by validation data
- Compare Top GCM1 Antibodies
- antibodies-online: Search results for available GCM1 related products ranked by validation data
- antibodies-online: Show 3 available GCM1 Proteins ranked by validation data
- Compare Top GCM1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for GCM1
- Search Santa Cruz Biotechnology (SCBT) for GCM1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GCM1
- Horizon Cell Lines for GCM1
- genomics-online: cdna clones - Search for available GCM1 CDNA products
- Overview of 98 available GCM1 gene related products
- orf clones - Search for available GCM1 ORF products
- Overview of 98 available GCM1 gene related products
- genomics-online: gRNA clones - Search for available GCM1 gRNA products
- Overview of 98 available GCM1 gene related products
- genomics-online: primer clones - Search for available GCM1 Primer products
- Overview of 98 available GCM1 gene related products
- genomics-online: shRNA clones - Search for available GCM1 shRNA products
- Overview of 98 available GCM1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GCM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GCM1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GCM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GCM1
- Biorbyt antibodies for GCM1
Sources for GCM1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody