Aliases for GCHFR Gene
External Ids for GCHFR Gene
Previous GeneCards Identifiers for GCHFR Gene
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
GeneCards Summary for GCHFR Gene
GCHFR (GTP Cyclohydrolase I Feedback Regulator) is a Protein Coding gene. Diseases associated with GCHFR include Isolated Ectopia Lentis. Among its related pathways are eNOS activation and regulation and Metabolism. Gene Ontology (GO) annotations related to this gene include enzyme binding and enzyme inhibitor activity.
UniProtKB/Swiss-Prot Summary for GCHFR Gene
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.