Aliases for GCHFR Gene
External Ids for GCHFR Gene
Previous GeneCards Identifiers for GCHFR Gene
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
GeneCards Summary for GCHFR Gene
GCHFR (GTP Cyclohydrolase I Feedback Regulator) is a Protein Coding gene. Among its related pathways are Metabolism and eNOS activation and regulation. Gene Ontology (GO) annotations related to this gene include enzyme binding and enzyme inhibitor activity.
UniProtKB/Swiss-Prot for GCHFR Gene
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.