External Ids for GCGR Gene
Previous GeneCards Identifiers for GCGR Gene
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
GeneCards Summary for GCGR Gene
GCGR (Glucagon Receptor) is a Protein Coding gene. Diseases associated with GCGR include Gcgr-Related Hyperglucagonemia and Diabetes Mellitus. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is GIPR.
UniProtKB/Swiss-Prot Summary for GCGR Gene
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
The glucagon receptor is a member of the glucagon receptor family that also includes GLP-1, GLP-2, secretin, GHRH and GIP receptors. The glucagon receptor regulates blood glucose levels and is predominantly expressed in the pancreas, liver and kidneys.