Aliases for GCC2 Gene
External Ids for GCC2 Gene
Previous GeneCards Identifiers for GCC2 Gene
The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
GeneCards Summary for GCC2 Gene
GCC2 (GRIP And Coiled-Coil Domain Containing 2) is a Protein Coding gene. Diseases associated with GCC2 include Achondrogenesis, Type Ia and Bladder Squamous Cell Carcinoma. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include identical protein binding and nucleotide binding. An important paralog of this gene is NUMA1.
UniProtKB/Swiss-Prot Summary for GCC2 Gene
Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.