Aliases for GCAT Gene
External Ids for GCAT Gene
Previous GeneCards Identifiers for GCAT Gene
The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. [provided by RefSeq, Jan 2010]
GeneCards Summary for GCAT Gene
GCAT (Glycine C-Acetyltransferase) is a Protein Coding gene. Diseases associated with GCAT include Retroperitoneum Carcinoma. Among its related pathways are Metabolism and Glycine, serine and threonine metabolism. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding and glycine C-acetyltransferase activity. An important paralog of this gene is ALAS2.