Aliases for GCA Gene
External Ids for GCA Gene
Previous GeneCards Identifiers for GCA Gene
This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Aug 2016]
GeneCards Summary for GCA Gene
GCA (Grancalcin) is a Protein Coding gene. Diseases associated with GCA include Singleton-Merten Syndrome 1 and Aicardi-Goutieres Syndrome 7. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is SRI.
UniProtKB/Swiss-Prot for GCA Gene
Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.