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Aliases for GC12M014554 Gene

Subcategory (RNA class) for GC12M014554 Gene

7SK RNA

Quality Score for this RNA gene is

15

Aliases for GC12M014554 Gene

No Aliases found

ORGUL Members for GC12M014554 Gene

No data available for External Ids for GC12M014554 Gene

Summaries for GC12M014554 Gene

GeneCards Summary for GC12M014554 Gene

GC12M014554 is an RNA Gene, and is affiliated with the 7SK RNA class.

fRNAdb sequence ontologies for GC12M014554 Gene - the ORGUL cluster for this gene includes several descriptions:

  • snRNA: A small nuclear RNA molecule involved in pre-mRNA splicing and processing.

  • 7SK RNA: 7SK was discovered as an abundant small nuclear RNA in the mid-70s but a possible function has only recently been suggested [1]. Two independent studies have found that 7SK RNA binds the CDK9/cyclin T complex (known as elongation factor P-TEFb). P-TEFb activates transcription by phosphorylating the C-terminal domain of RNA polymerase II. This process is negatively regulated by the 7SK RNP. The secondary structure of 7SK RNA shown here was proposed by Wasserman and Steitz on the basis of chemical modification and enzymatic cleavage experiments [2]. This family contains a number of annotated pseudogenes and 7SK derived repeats. The threshold is artificially high to minimise the pseudogene count.

View fRNAdb secondary structures for GC12M014554

Additional gene information for GC12M014554 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for GC12M014554 Gene

Genomics for GC12M014554 Gene

GeneHancer (GH) Regulatory Elements for GC12M014554 Gene

Promoters and enhancers for GC12M014554 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J014553 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 600.7 -0.6 -583 1.9 POLR2A NFIC CTCF GC12M014554 RN7SKP134 HIST4H4 GUCY2C ERP27 PLBD1 PLBD1-AS1
GH12J014558 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.7 -4.8 -4760 1.3 IKZF1 CTCF EBF1 PLBD1-AS1 PLBD1 GC12M014554 RN7SKP134
GH12J014566 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 0.4 -13.5 -13506 3.8 ZFX MTA1 NRF1 ATF1 ZNF24 EZH2 MGA POLR2A USF1 YY1 PLBD1 PLBD1-AS1 GUCY2C ATF7IP ENSG00000261324 ENSG00000214772 WBP11 HIST4H4 GC12M014554 RN7SKP134
GH12J014560 Enhancer 0.7 ENCODE dbSUPER 0.4 -7.7 -7687 1.7 SP1 YY1 HNF4A RXRA ERP27 PLBD1 PLBD1-AS1 RN7SKP134 GC12M014554
GH12J014545 Enhancer 0.6 ENCODE dbSUPER 0.4 +8.3 8340 0.9 NFIB NFIC IKZF1 PLBD1 PLBD1-AS1 GUCY2C RN7SKP134 GC12M014554 ENSG00000255649
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GC12M014554 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GC12M014554 Gene

Genomic Locations for GC12M014554 Gene
chr12:14,553,666-14,553,970
(GRCh38/hg38)
Size:
305 bases
Orientation:
Minus strand

Genomic View for GC12M014554 Gene

Genes around GC12M014554 on UCSC Golden Path with GeneCards custom track

GC12M014554 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GC12M014554 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

ORGUL Member Location for GC12M014554 Gene

ORGUL Member Location for GC12M014554 gene

No data available for Cytogenetic band and RefSeq DNA sequence for GC12M014554 Gene

Proteins for GC12M014554 Gene

Post-translational modifications for GC12M014554 Gene

No Post-translational modifications

No data available for DME Specific Peptides for GC12M014554 Gene

Domains & Families for GC12M014554 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GC12M014554 Gene

Function for GC12M014554 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GC12M014554 Gene

Localization for GC12M014554 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GC12M014554 Gene

Pathways & Interactions for GC12M014554 Gene

PathCards logo

SuperPathways for GC12M014554 Gene

No Data Available

Interacting Proteins for GC12M014554 Gene

Gene Ontology (GO) - Biological Process for GC12M014554 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GC12M014554 Gene

Drugs & Compounds for GC12M014554 Gene

No Compound Related Data Available

Transcripts for GC12M014554 Gene

fRNAdb Secondary structures for GC12M014554 Gene

  • FR057780

Alternative Splicing Database (ASD) splice patterns (SP) for GC12M014554 Gene

No ASD Table

Relevant External Links for GC12M014554 Gene

GeneLoc Exon Structure for
GC12M014554

No data available for mRNA/cDNA for GC12M014554 Gene

Expression for GC12M014554 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GC12M014554 Gene

Orthologs for GC12M014554 Gene

No data available for Orthologs and Evolution for GC12M014554 Gene

Paralogs for GC12M014554 Gene

No data available for Paralogs for GC12M014554 Gene

Variants for GC12M014554 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for GC12M014554 Gene

Disorders for GC12M014554 Gene

No disorders were found for GC12M014554 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for GC12M014554 Gene

Publications for GC12M014554 Gene

  1. Transcription: surprising role for an elusive small nuclear RNA. (PMID: 11864590) Blencowe BJ (Current biology : CB 2002) 1
  2. Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function. (PMID: 1646389) Wassarman DA … Steitz JA (Molecular and cellular biology 1991) 1

No data available for External Links for GC12M014554 Gene

Products for GC12M014554 Gene

Sources for GC12M014554 Gene

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