Aliases for GBP7 Gene
External Ids for GBP7 Gene
Previous GeneCards Identifiers for GBP7 Gene
Guanylate-binding proteins, such as GBP7, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]
GeneCards Summary for GBP7 Gene
GBP7 (Guanylate Binding Protein 7) is a Protein Coding gene. Diseases associated with GBP7 include Malaria. Among its related pathways are Innate Immune System and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP4.
UniProtKB/Swiss-Prot Summary for GBP7 Gene
Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).