Guanylate-binding proteins, such as GBP7, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008] See more...

Aliases for GBP7 Gene

Aliases for GBP7 Gene

  • Guanylate Binding Protein 7 2 3 5
  • Guanine Nucleotide-Binding Protein 7 3 4
  • Guanylate-Binding Protein 7 3 4
  • GTP-Binding Protein 7 3 4
  • GBP-7 3 4
  • GBP4L 3 4
  • Guanylate-Binding Protein 4-Like 4

External Ids for GBP7 Gene

Previous GeneCards Identifiers for GBP7 Gene

  • GC01M089310
  • GC01M089370
  • GC01M089597
  • GC01M087714

Summaries for GBP7 Gene

Entrez Gene Summary for GBP7 Gene

  • Guanylate-binding proteins, such as GBP7, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]

GeneCards Summary for GBP7 Gene

GBP7 (Guanylate Binding Protein 7) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and NOD-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP4.

UniProtKB/Swiss-Prot Summary for GBP7 Gene

  • Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).

Additional gene information for GBP7 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GBP7 Gene

Genomics for GBP7 Gene

GeneHancer (GH) Regulatory Elements for GBP7 Gene

Promoters and enhancers for GBP7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J089123 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 37.4 +49.5 49455 7.2 ZNF24 ZBTB40 RBPJ SMARCE1 NFYC RELA HLF RAD21 DACH1 TEAD4 GBP2 ENSG00000286802 LOC105378842 piR-31470-024 GBP1 GBP7 GBP5 GBP4 GBP3 ENSG00000237568
GH01J089081 Enhancer 0.7 Ensembl ENCODE 36.3 +94.6 94639 2 RELA ZBTB33 IKZF1 DPF2 BCLAF1 TRIM28 IRF4 GBP7 GBP3 GBP5 RBMXL1 piR-61945-027 piR-38732-002 LOC105378841 lnc-PKN2-1
GH01J089197 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 15 -23.3 -23309 4.7 ETV6 RELA RAD21 TEAD4 NKRF SP1 CBFA2T2 MLLT1 CREM ZNF639 ENSG00000284734 GBP4 GBP3 GBP7 ENSG00000284637
GH01J089103 Enhancer 0.5 dbSUPER 35.7 +69.2 69188 7.6 ZNF316 NFE2 MAFG CREM NRF1 JUND BACH1 EMSY PTGES3P1 GBP7 GBP3 GBP6 ENSG00000237568 GBP5 lnc-GBP2-1 piR-31470-024 GBP2 lnc-PKN2-1
GH01J089170 Enhancer 0.6 Ensembl 26 +4.9 4939 0.6 ZKSCAN8 BACH1 ZNF639 CAVIN1 ZNF740 NFE2 ZNF766 E2F5 GABPA GTF2A2 GBP7 PKN2 GBP4 GBP5 GBP1 RF00017-262 LOC105378842 lnc-PKN2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GBP7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GBP7 gene promoter:
  • AML1a
  • C/EBPalpha
  • GATA-2
  • LCR-F1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • PPAR-gamma2

Genomic Locations for GBP7 Gene

Genomic Locations for GBP7 Gene
chr1:89,131,742-89,176,040
(GRCh38/hg38)
Size:
44,299 bases
Orientation:
Minus strand
chr1:89,597,434-89,641,723
(GRCh37/hg19)
Size:
44,290 bases
Orientation:
Minus strand

Genomic View for GBP7 Gene

Genes around GBP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBP7 Gene

Proteins for GBP7 Gene

  • Protein details for GBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8V2-GBP7_HUMAN
    Recommended name:
    Guanylate-binding protein 7
    Protein Accession:
    Q8N8V2

    Protein attributes for GBP7 Gene

    Size:
    638 amino acids
    Molecular mass:
    72513 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GBP7 Gene

Post-translational modifications for GBP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GBP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GBP7 Gene

Domains & Families for GBP7 Gene

Gene Families for GBP7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GBP7 Gene

GenScript: Design optimal peptide antigens:
  • Guanylate-binding protein 4-like (GBP7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N8V2

UniProtKB/Swiss-Prot:

GBP7_HUMAN :
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP7: view

Function for GBP7 Gene

Molecular function for GBP7 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).

Gene Ontology (GO) - Molecular Function for GBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA,IEA 21873635
GO:0005525 GTP binding IBA,IEA 21873635
genes like me logo Genes that share ontologies with GBP7: view
genes like me logo Genes that share phenotypes with GBP7: view

Animal Model Products

CRISPR Products

miRNA for GBP7 Gene

miRTarBase miRNAs that target GBP7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GBP7

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GBP7 Gene

Localization for GBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GBP7 Gene

Membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GBP7 gene
Compartment Confidence
extracellular 3
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for GBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0020005 symbiont-containing vacuole membrane IBA 21873635
GO:0031410 cytoplasmic vesicle IBA 21873635
genes like me logo Genes that share ontologies with GBP7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GBP7 Gene

Pathways & Interactions for GBP7 Gene

genes like me logo Genes that share pathways with GBP7: view

Pathways by source for GBP7 Gene

Gene Ontology (GO) - Biological Process for GBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042832 defense response to protozoan IBA 21873635
GO:0050830 defense response to Gram-positive bacterium IBA 21873635
GO:0071346 cellular response to interferon-gamma IBA 21873635
genes like me logo Genes that share ontologies with GBP7: view

No data available for SIGNOR curated interactions for GBP7 Gene

Drugs & Compounds for GBP7 Gene

(1) Drugs for GBP7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GBP7: view

Transcripts for GBP7 Gene

mRNA/cDNA for GBP7 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(207) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GBP7

Alternative Splicing Database (ASD) splice patterns (SP) for GBP7 Gene

No ASD Table

Relevant External Links for GBP7 Gene

GeneLoc Exon Structure for
GBP7
ECgene alternative splicing isoforms for
GBP7

Expression for GBP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GBP7 Gene

mRNA differential expression in normal tissues according to GTEx for GBP7 Gene

This gene is overexpressed in Liver (x49.0).

Protein differential expression in normal tissues from HIPED for GBP7 Gene

This gene is overexpressed in Cervix (58.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GBP7 Gene



NURSA nuclear receptor signaling pathways regulating expression of GBP7 Gene:

GBP7

SOURCE GeneReport for Unigene cluster for GBP7 Gene:

Hs.591450

Evidence on tissue expression from TISSUES for GBP7 Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with GBP7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GBP7 Gene

Orthologs for GBP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GBP7 33 32
  • 99.27 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC685067 32
  • 75.63 (n)
mouse
(Mus musculus)
Mammalia Gbp7 17 33 32
  • 75.29 (n)
Gbp3 33
  • 70 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 33
  • 69 (a)
ManyToMany
-- 33
  • 69 (a)
ManyToMany
-- 33
  • 69 (a)
ManyToMany
-- 33
  • 69 (a)
ManyToMany
BT.37579 33
  • 66 (a)
ManyToMany
GBP4 33
  • 65 (a)
ManyToMany
-- 33
  • 64 (a)
ManyToMany
GBP6 33
  • 63 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 61 (a)
ManyToMany
-- 33
  • 58 (a)
ManyToMany
-- 33
  • 52 (a)
ManyToMany
-- 33
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 33
  • 37 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gbp4 33
  • 34 (a)
ManyToMany
Species where no ortholog for GBP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GBP7 Gene

ENSEMBL:
Gene Tree for GBP7 (if available)
TreeFam:
Gene Tree for GBP7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GBP7: view image

Paralogs for GBP7 Gene

Paralogs for GBP7 Gene

(7) SIMAP similar genes for GBP7 Gene using alignment to 1 proteins:

  • GBP7_HUMAN
genes like me logo Genes that share paralogs with GBP7: view

Variants for GBP7 Gene

Sequence variations from dbSNP and Humsavar for GBP7 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000015130 -- 89,168,178(-) A/G intron_variant
rs1000076647 -- 89,145,288(-) C/T intron_variant
rs1000215124 -- 89,161,298(-) A/G intron_variant
rs1000310604 -- 89,174,120(-) C/T intron_variant
rs1000317964 -- 89,155,377(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GBP7 Gene

Variant ID Type Subtype PubMed ID
esv2714562 CNV deletion 23290073
nsv546796 CNV loss 21841781
nsv830548 CNV gain 17160897

Variation tolerance for GBP7 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GBP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GBP7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP7 Gene

Disorders for GBP7 Gene

Additional Disease Information for GBP7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GBP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBP7 Gene

Publications for GBP7 Gene

  1. Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. (PMID: 20459687) Eid NA … Ibrahim ME (Malaria journal 2010) 3 43 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 56

Products for GBP7 Gene

Sources for GBP7 Gene