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Aliases for GBP6 Gene

Aliases for GBP6 Gene

  • Guanylate Binding Protein Family Member 6 2 3 5
  • Guanine Nucleotide-Binding Protein 6 3 4
  • GTP-Binding Protein 6 3 4
  • GBP-6 3 4
  • Guanylate Binding Protein Family, Member 6 2
  • Guanylate-Binding Protein 6 3

External Ids for GBP6 Gene

Previous GeneCards Identifiers for GBP6 Gene

  • GC01P089542
  • GC01P089602
  • GC01P089829
  • GC01P087946

Summaries for GBP6 Gene

Entrez Gene Summary for GBP6 Gene

  • Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]

GeneCards Summary for GBP6 Gene

GBP6 (Guanylate Binding Protein Family Member 6) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP4.

UniProtKB/Swiss-Prot for GBP6 Gene

  • Binds GTP, GDP and GMP.

Additional gene information for GBP6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP6 Gene

Genomics for GBP6 Gene

GeneHancer (GH) Regulatory Elements for GBP6 Gene

Promoters and enhancers for GBP6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I089362 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 554.8 -0.2 -155 1.8 BACH1 EBF1 BATF IRF4 ZNF316 IKZF2 MAFK RUNX3 SRF NR2F1 GBP6 LRRC8B LOC101927975 PIR56754
GH01I089365 Enhancer 0.2 ENCODE 550.8 +1.5 1478 0.6 GBP6 LRRC8B CAPNS1P1
GH01I088990 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -371.3 -371320 4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 KYAT3 RBMXL1 GBP3 GBP5 GBP6 GBP7 PTGES3P1 GC01M088952
GH01I089020 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 10.6 -341.5 -341525 2.7 MEIS2 SOX13 IRF2 FOXA2 TAF1 SAP130 CEBPG YY1 ZFHX2 POLR2A GBP3 ENSG00000202385 GC01M089021 GBP6 GBP5 PKN2 GBP1
GH01I089284 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -77.4 -77437 3.4 JUNB MAX MAFG BATF YY1 ZNF316 MAFF HNF4G HNF4A EMSY GBP1 GBP5 GBP4 GBP2 GBP6 GTF2B LRRC8C GBP3 GC01P089283 LOC729930
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GBP6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GBP6 gene promoter:

Genomic Locations for GBP6 Gene

Genomic Locations for GBP6 Gene
24,284 bases
Plus strand

Genomic View for GBP6 Gene

Genes around GBP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBP6 Gene

Proteins for GBP6 Gene

  • Protein details for GBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanylate-binding protein 6
    Protein Accession:
    Secondary Accessions:
    • A2RRM3
    • Q6ZN86
    • Q7Z3F0

    Protein attributes for GBP6 Gene

    633 amino acids
    Molecular mass:
    72427 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GBP6 Gene


neXtProt entry for GBP6 Gene

Post-translational modifications for GBP6 Gene

No Post-translational modifications

Other Protein References for GBP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GBP6 Gene

Domains & Families for GBP6 Gene

Gene Families for GBP6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP6: view

Function for GBP6 Gene

Molecular function for GBP6 Gene

UniProtKB/Swiss-Prot Function:
Binds GTP, GDP and GMP.

Phenotypes From GWAS Catalog for GBP6 Gene

Gene Ontology (GO) - Molecular Function for GBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GBP6: view

Phenotypes for GBP6 Gene

genes like me logo Genes that share phenotypes with GBP6: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GBP6 Gene

Localization for GBP6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GBP6 gene
Compartment Confidence
extracellular 5
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA,IDA 19199708
genes like me logo Genes that share ontologies with GBP6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GBP6 Gene

Pathways & Interactions for GBP6 Gene

genes like me logo Genes that share pathways with GBP6: view

Pathways by source for GBP6 Gene

1 Sino Biological pathway for GBP6 Gene

Interacting Proteins for GBP6 Gene

Gene Ontology (GO) - Biological Process for GBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response ISS --
GO:0042742 defense response to bacterium ISS --
GO:0071346 cellular response to interferon-gamma ISS --
genes like me logo Genes that share ontologies with GBP6: view

No data available for SIGNOR curated interactions for GBP6 Gene

Drugs & Compounds for GBP6 Gene

(2) Drugs for GBP6 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with GBP6: view

Transcripts for GBP6 Gene

mRNA/cDNA for GBP6 Gene

(3) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GBP6 Gene

Guanylate binding protein family, member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GBP6 Gene

No ASD Table

Relevant External Links for GBP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GBP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GBP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GBP6 Gene

This gene is overexpressed in Esophagus - Mucosa (x37.7) and Minor Salivary Gland (x8.2).

Protein differential expression in normal tissues from HIPED for GBP6 Gene

This gene is overexpressed in Cervix (55.0) and Esophagus (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GBP6 Gene

Protein tissue co-expression partners for GBP6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GBP6 Gene:


SOURCE GeneReport for Unigene cluster for GBP6 Gene:


Evidence on tissue expression from TISSUES for GBP6 Gene

  • Eye(4.1)
genes like me logo Genes that share expression patterns with GBP6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GBP6 Gene

Orthologs for GBP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GBP6 33 34
  • 99.53 (n)
(Bos Taurus)
Mammalia GBP7 33
  • 84.18 (n)
-- 34
  • 75 (a)
GBP6 34
  • 73 (a)
-- 34
  • 72 (a)
(Canis familiaris)
Mammalia GBP6 33 34
  • 82.3 (n)
(Rattus norvegicus)
Mammalia Mpa2l 33
  • 79.14 (n)
(Mus musculus)
Mammalia Gbp6 33 34
  • 78.81 (n)
Gbp11 34 34
  • 75 (a)
Gbp8 34
  • 69 (a)
Gbp9 16 34
  • 68 (a)
Gbp10 34
  • 68 (a)
Gbp4 34
  • 63 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 61 (a)
-- 34
  • 60 (a)
-- 34
  • 51 (a)
-- 34
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
(Gallus gallus)
Aves -- 34
  • 22 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489592 33
  • 58.4 (n)
(Danio rerio)
Actinopterygii gbp3 33
  • 55.81 (n)
CABZ01068208.1 34
  • 39 (a)
Species where no ortholog for GBP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GBP6 Gene

Gene Tree for GBP6 (if available)
Gene Tree for GBP6 (if available)

Paralogs for GBP6 Gene

Paralogs for GBP6 Gene

(7) SIMAP similar genes for GBP6 Gene using alignment to 2 proteins: Pseudogenes for GBP6 Gene

genes like me logo Genes that share paralogs with GBP6: view

Variants for GBP6 Gene

Sequence variations from dbSNP and Humsavar for GBP6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000003489 -- 89,370,234(+) G/A intron_variant
rs1000006190 -- 89,383,131(+) T/C intron_variant
rs1000071573 -- 89,371,437(+) C/T intron_variant
rs1000097538 -- 89,379,354(+) G/T intron_variant
rs1000150369 -- 89,362,770(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GBP6 Gene

Variant ID Type Subtype PubMed ID
esv3586760 CNV gain 21293372
esv3586763 CNV gain 21293372
nsv1078569 CNV deletion 25765185
nsv1142762 CNV deletion 24896259

Variation tolerance for GBP6 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GBP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP6 Gene

Disorders for GBP6 Gene

Additional Disease Information for GBP6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GBP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBP6 Gene

Publications for GBP6 Gene

  1. Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study. (PMID: 20423481) Suarez-Gestal M … Gonzalez A (Arthritis research & therapy 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S … Seielstad M (Genes and immunity 2010) 3 58
  5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M … Yates JR (Journal of proteome research 2009) 3 58

Products for GBP6 Gene

Sources for GBP6 Gene

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