Aliases for GBP5 Gene
External Ids for GBP5 Gene
Previous GeneCards Identifiers for GBP5 Gene
This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
GeneCards Summary for GBP5 Gene
GBP5 (Guanylate Binding Protein 5) is a Protein Coding gene. Diseases associated with GBP5 include Chronic Active Epstein-Barr Virus Infection. Among its related pathways are Innate Immune System and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and GTPase activity. An important paralog of this gene is GBP3.
UniProtKB/Swiss-Prot Summary for GBP5 Gene
As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).