Aliases for GBP5 Gene
External Ids for GBP5 Gene
Previous GeneCards Identifiers for GBP5 Gene
This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
GeneCards Summary for GBP5 Gene
GBP5 (Guanylate Binding Protein 5) is a Protein Coding gene. Diseases associated with GBP5 include Chronic Active Epstein-Barr Virus Infection. Among its related pathways are Interferon gamma signaling and NOD-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and GTPase activity. An important paralog of this gene is GBP1.
UniProtKB/Swiss-Prot Summary for GBP5 Gene
As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).