Aliases for GBP4 Gene
External Ids for GBP4 Gene
Previous GeneCards Identifiers for GBP4 Gene
Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]
GeneCards Summary for GBP4 Gene
GBP4 (Guanylate Binding Protein 4) is a Protein Coding gene. Diseases associated with GBP4 include High Pressure Neurological Syndrome and Osteopetrosis, Autosomal Dominant 2. Among its related pathways are Innate Immune System and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP7.
UniProtKB/Swiss-Prot Summary for GBP4 Gene
Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).