Aliases for GBP4 Gene
External Ids for GBP4 Gene
Previous GeneCards Identifiers for GBP4 Gene
Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]
GeneCards Summary for GBP4 Gene
GBP4 (Guanylate Binding Protein 4) is a Protein Coding gene. Diseases associated with GBP4 include Osteopetrosis, Autosomal Dominant 2. Among its related pathways are Interferon gamma signaling and NOD-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP7.
UniProtKB/Swiss-Prot Summary for GBP4 Gene
Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).