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Aliases for GBP4 Gene

Aliases for GBP4 Gene

  • Guanylate Binding Protein 4 2 3 5
  • Guanine Nucleotide-Binding Protein 4 3 4
  • GTP-Binding Protein 4 3 4
  • GBP-4 3 4
  • Guanylate-Binding Protein 4 3
  • EC 3.6.5.- 4
  • Mpa2 3

External Ids for GBP4 Gene

Previous GeneCards Identifiers for GBP4 Gene

  • GC01M090127
  • GC01M088817
  • GC01M088984
  • GC01M089114
  • GC01M089359
  • GC01M089420
  • GC01M089646
  • GC01M087764

Summaries for GBP4 Gene

Entrez Gene Summary for GBP4 Gene

  • Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]

GeneCards Summary for GBP4 Gene

GBP4 (Guanylate Binding Protein 4) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP7.

UniProtKB/Swiss-Prot for GBP4 Gene

  • Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).

Additional gene information for GBP4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GBP4 Gene

Genomics for GBP4 Gene

GeneHancer (GH) Regulatory Elements for GBP4 Gene

Promoters and enhancers for GBP4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I089197 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.7 -677 4.1 HDGF PKNOX1 ATF1 SMAD1 BMI1 BATF KLF5 IRF4 RAD21 ZBTB40 GBP4 ENSG00000284734 GBP3 GBP7 ENSG00000284637
GH01I089271 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 25.3 -74.8 -74752 4 STAT1 NFATC3 CEBPB CEBPG EP300 RAD21 YY1 RELA ATF4 JUND GBP5 GBP1 GBP4 GBP2 GTF2B GBP3 LRRC8C GC01P089283 LOC100421401
GH01I089284 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 35.2 -87.5 -87490 3.4 JUNB MAX MAFG BATF YY1 ZNF316 MAFF HNF4G HNF4A EMSY GBP1 GBP5 GBP4 GBP2 GBP6 GTF2B LRRC8C GBP3 GC01P089283 LOC729930
GH01I089128 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 28.3 +69.7 69667 1.8 HDAC1 TAF9B ARNT SIN3A ZBTB40 RAD21 YY1 E2F8 ZNF143 ATF7 LOC105378842 GBP1 GBP5 GBP4 GBP2 GBP7 GTF2B GBP3 PTGES3P1
GH01I089277 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 29.2 -80.2 -80217 2.8 PKNOX1 SP7 GBP1 GBP5 GBP4 GBP2 LOC100421401 GBP7 GTF2B LRRC8C KYAT3 GBP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GBP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GBP4 gene promoter:

Genomic Locations for GBP4 Gene

Genomic Locations for GBP4 Gene
17,803 bases
Minus strand

Genomic View for GBP4 Gene

Genes around GBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBP4 Gene

Proteins for GBP4 Gene

  • Protein details for GBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanylate-binding protein 4
    Protein Accession:
    Secondary Accessions:
    • B2R630
    • Q05D63
    • Q6NSL0
    • Q86T99

    Protein attributes for GBP4 Gene

    640 amino acids
    Molecular mass:
    73165 Da
    Quaternary structure:
    • Heterodimer with other family members, including GBP1, GBP2 and GBP5 (PubMed:21151871). Dimerization regulates subcellular location.
    • Sequence=BAC85144.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for GBP4 Gene

Post-translational modifications for GBP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GBP4 Gene

Domains & Families for GBP4 Gene

Gene Families for GBP4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GBP4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP4: view

Function for GBP4 Gene

Molecular function for GBP4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GTP + H(2)O = GDP + phosphate.
UniProtKB/Swiss-Prot Function:
Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).
UniProtKB/Swiss-Prot Induction:
By IFNG during macrophage activation.

Enzyme Numbers (IUBMB) for GBP4 Gene

Phenotypes From GWAS Catalog for GBP4 Gene

Gene Ontology (GO) - Molecular Function for GBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GBP4: view
genes like me logo Genes that share phenotypes with GBP4: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GBP4 Gene

Localization for GBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GBP4 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Golgi apparatus membrane. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi aparatus. {ECO:0000269 PubMed:21151871}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GBP4 gene
Compartment Confidence
nucleus 4
golgi apparatus 3
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GBP4: view

Pathways & Interactions for GBP4 Gene

genes like me logo Genes that share pathways with GBP4: view

Pathways by source for GBP4 Gene

Interacting Proteins for GBP4 Gene

Gene Ontology (GO) - Biological Process for GBP4 Gene


No data available for SIGNOR curated interactions for GBP4 Gene

Drugs & Compounds for GBP4 Gene

(1) Drugs for GBP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GBP4: view

Transcripts for GBP4 Gene

mRNA/cDNA for GBP4 Gene

Unigene Clusters for GBP4 Gene

Guanylate binding protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GBP4 Gene

No ASD Table

Relevant External Links for GBP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GBP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GBP4 Gene

Protein differential expression in normal tissues from HIPED for GBP4 Gene

This gene is overexpressed in Lymph node (20.7) and Heart (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GBP4 Gene

Protein tissue co-expression partners for GBP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of GBP4 Gene:


SOURCE GeneReport for Unigene cluster for GBP4 Gene:


Evidence on tissue expression from TISSUES for GBP4 Gene

  • Spleen(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GBP4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GBP4 Gene

Orthologs for GBP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GBP4 33 34
  • 99.27 (n)
(Mus musculus)
Mammalia Gbp3 33 16 34
  • 78.55 (n)
Gbp7 34
  • 68 (a)
(Rattus norvegicus)
Mammalia Gbp4 33
  • 78.5 (n)
(Bos Taurus)
Mammalia -- 34
  • 70 (a)
-- 34
  • 70 (a)
-- 34
  • 69 (a)
-- 34
  • 69 (a)
BT.37579 34
  • 68 (a)
-- 34
  • 66 (a)
GBP4 34
  • 66 (a)
GBP6 34
  • 63 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 58 (a)
-- 34
  • 58 (a)
-- 34
  • 50 (a)
-- 34
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
(Gallus gallus)
Aves -- 34
  • 33 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496810 33
  • 54.56 (n)
(Danio rerio)
Actinopterygii gbp2 34
  • 43 (a)
Species where no ortholog for GBP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GBP4 Gene

Gene Tree for GBP4 (if available)
Gene Tree for GBP4 (if available)

Paralogs for GBP4 Gene

Paralogs for GBP4 Gene

(7) SIMAP similar genes for GBP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GBP4: view

Variants for GBP4 Gene

Sequence variations from dbSNP and Humsavar for GBP4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000354273 -- 89,200,152(-) T/C upstream_transcript_variant
rs1000483885 -- 89,193,320(-) C/G coding_sequence_variant, missense_variant
rs1000619580 -- 89,182,171(-) G/A/T 3_prime_UTR_variant
rs1000923684 -- 89,199,910(-) C/T upstream_transcript_variant
rs1001095737 -- 89,186,837(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GBP4 Gene

Variant ID Type Subtype PubMed ID
esv2714562 CNV deletion 23290073
nsv546796 CNV loss 21841781
nsv830548 CNV gain 17160897

Variation tolerance for GBP4 Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GBP4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP4 Gene

Disorders for GBP4 Gene

Additional Disease Information for GBP4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GBP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBP4 Gene

Publications for GBP4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner. (PMID: 21151871) Britzen-Laurent N … Stürzl M (PloS one 2010) 3 4 58
  3. Unique features of different members of the human guanylate-binding protein family. (PMID: 17266443) Tripal P … Stürzl M (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007) 3 4 58
  4. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. (PMID: 16689661) Olszewski MA … Vestal DJ (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2006) 2 3 58
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard SM … Kanmogne GD (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014) 3 58

Products for GBP4 Gene

Sources for GBP4 Gene

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