This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013] See more...

Aliases for GBP2 Gene

Aliases for GBP2 Gene

  • Guanylate Binding Protein 2 2 3 5
  • Guanylate Binding Protein 2, Interferon-Inducible 2 3
  • Interferon-Induced Guanylate-Binding Protein 2 3 4
  • Guanine Nucleotide-Binding Protein 2 3 4
  • Guanylate-Binding Protein 2 3 4
  • GTP-Binding Protein 2 3 4
  • EC 3.6.5.- 4
  • HuGBP-2 4
  • GBP-2 4
  • GBP2 5

External Ids for GBP2 Gene

Previous GeneCards Identifiers for GBP2 Gene

  • GC01M090050
  • GC01M088741
  • GC01M088908
  • GC01M089038
  • GC01M089283
  • GC01M089344
  • GC01M089345
  • GC01M089571
  • GC01M087690

Summaries for GBP2 Gene

Entrez Gene Summary for GBP2 Gene

  • This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]

GeneCards Summary for GBP2 Gene

GBP2 (Guanylate Binding Protein 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP3.

UniProtKB/Swiss-Prot Summary for GBP2 Gene

  • Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).

Gene Wiki entry for GBP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GBP2 Gene

Genomics for GBP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GBP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J089123 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 277.8 +23.9 23871 7.2 CEBPA IRF2 CEBPB ARNT TRIM22 SAP130 EP300 TAL1 RXRA PRDM1 GBP2 LOC105378842 piR-31470-024 GBP1 GBP7 GBP5 GBP4 GBP3 ENSG00000237568 GTF2B
GH01J089269 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 25.2 -122.1 -122088 6.3 CEBPB EP300 RXRA MYC JUND MAX RAD21 ATF2 ATF4 HNF4A GBP5 MN296824 piR-30449-006 piR-39098-006 GBP1 GBP4 GBP2 GTF2B GBP3 LRRC8C
GH01J089309 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 15.9 -161.0 -161044 3.8 RXRA ZNF316 JUND NFE2 BATF NFE2L2 HNF4A ELF1 MAFG NR2F1 GBP1 GBP5 GBP4 GBP2 GTF2B PKN2 GBP3 ENSG00000231613 LRRC8C HSALNG0005057
GH01J089351 Enhancer 0.8 FANTOM5 Ensembl 21.4 -201.3 -201345 2.8 SPI1 BHLHE40 IKZF1 BMI1 NR2F1 ZNF217 CREB1 ATF7 ZNF629 MTA2 GBP1 GBP5 GBP2 GBP4 GTF2B GBP6 LRRC8B LRRC8C GBP3 piR-55110-005
GH01J089284 Enhancer 1 FANTOM5 ENCODE dbSUPER 14.6 -136.0 -135984 3.4 MAFF ZNF316 BATF MAFK HNF4A MAFG JUNB MAX SP1 HNF4G GBP1 GBP5 GBP4 GBP2 GBP6 GTF2B LRRC8C GBP3 ENSG00000238081 HSALNG0005055
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GBP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GBP2

Top Transcription factor binding sites by QIAGEN in the GBP2 gene promoter:
  • AML1a

Genomic Locations for GBP2 Gene

Latest Assembly
chr1:89,106,132-89,150,456
(GRCh38/hg38)
Size:
44,325 bases
Orientation:
Minus strand

Previous Assembly
chr1:89,571,815-89,591,797
(GRCh37/hg19 by Entrez Gene)
Size:
19,983 bases
Orientation:
Minus strand

chr1:89,571,815-89,616,139
(GRCh37/hg19 by Ensembl)
Size:
44,325 bases
Orientation:
Minus strand

Genomic View for GBP2 Gene

Genes around GBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GBP2 Gene

Proteins for GBP2 Gene

  • Protein details for GBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32456-GBP2_HUMAN
    Recommended name:
    Guanylate-binding protein 2
    Protein Accession:
    P32456
    Secondary Accessions:
    • Q6GPH0
    • Q6IAU2
    • Q86TB0

    Protein attributes for GBP2 Gene

    Size:
    591 amino acids
    Molecular mass:
    67209 Da
    Quaternary structure:
    • Homodimer; homodimerization occurs upon GTP-binding and is required for the association with membranous structures. Heterodimer with other family members, including GBP1, GBP3, GBP4 and GBP5.

neXtProt entry for GBP2 Gene

Post-translational modifications for GBP2 Gene

  • Isoprenylation is required for proper subcellular location.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GBP2 Gene

Domains & Families for GBP2 Gene

Gene Families for GBP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GBP2 Gene

InterPro:
Blocks:
  • Guanylate-binding protein
ProtoNet:

Suggested Antigen Peptide Sequences for GBP2 Gene

GenScript: Design optimal peptide antigens:
  • Guanine nucleotide-binding protein 2 (GBP2_HUMAN)
  • GBP2 protein (Q8TCE5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P32456

UniProtKB/Swiss-Prot:

GBP2_HUMAN :
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP2: view

Function for GBP2 Gene

Molecular function for GBP2 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence={ECO:0000269|PubMed:8706832};.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma during macrophage activation, and by TNF and IL1B.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=313 uM for GTP {ECO:0000269|PubMed:8706832};

Enzyme Numbers (IUBMB) for GBP2 Gene

Phenotypes From GWAS Catalog for GBP2 Gene

Gene Ontology (GO) - Molecular Function for GBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IBA 21873635
GO:0005515 protein binding IPI 18985028
GO:0005525 GTP binding TAS,IBA 21873635
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GBP2: view
genes like me logo Genes that share phenotypes with GBP2: view

Animal Models for GBP2 Gene

MGI Knock Outs for GBP2:
  • Gbp2 Gbp2<tm1b(KOMP)Wtsi>
  • Gbp2 Gbp2<tm1.1Kpf>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GBP2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GBP2 Gene

Localization for GBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GBP2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus membrane. Membrane. Lipid-anchor. Note=GBP2-GBP5 dimers localize to the Golgi apparatus. {ECO:0000269 PubMed:21151871}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GBP2 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
cytoskeleton 4
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IDA 17266443
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 21151871
GO:0005794 Golgi apparatus IEA,IDA 17266443
genes like me logo Genes that share ontologies with GBP2: view

Pathways & Interactions for GBP2 Gene

genes like me logo Genes that share pathways with GBP2: view

Gene Ontology (GO) - Biological Process for GBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 1715024
GO:0034504 protein localization to nucleus IDA 21151871
GO:0042832 defense response to protozoan IBA 21873635
GO:0050830 defense response to Gram-positive bacterium IBA 21873635
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with GBP2: view

No data available for SIGNOR curated interactions for GBP2 Gene

Drugs & Compounds for GBP2 Gene

(1) Drugs for GBP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GBP2: view

Transcripts for GBP2 Gene

mRNA/cDNA for GBP2 Gene

1 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GBP2

Alternative Splicing Database (ASD) splice patterns (SP) for GBP2 Gene

No ASD Table

Relevant External Links for GBP2 Gene

GeneLoc Exon Structure for
GBP2

Expression for GBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GBP2 Gene

mRNA differential expression in normal tissues according to GTEx for GBP2 Gene

This gene is overexpressed in Whole Blood (x9.1).

Protein differential expression in normal tissues from HIPED for GBP2 Gene

This gene is overexpressed in Spleen (19.0), Lymph node (7.0), and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GBP2 Gene



Protein tissue co-expression partners for GBP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GBP2

SOURCE GeneReport for Unigene cluster for GBP2 Gene:

Hs.386567

Evidence on tissue expression from TISSUES for GBP2 Gene

  • Nervous system(4.7)
  • Skin(4.5)
  • Blood(3.4)
  • Spleen(3)
  • Intestine(2.9)
  • Lymph node(2.8)
  • Lung(2.6)
  • Liver(2.3)
  • Muscle(2.3)
  • Heart(2.3)
  • Kidney(2.2)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with GBP2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GBP2 Gene

Orthologs for GBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GBP2 30 31
  • 99.49 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GBP2 30
  • 84.82 (n)
-- 31
  • 72 (a)
OneToMany
-- 31
  • 71 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Gbp2 30
  • 77.87 (n)
Mouse
(Mus musculus)
Mammalia Gbp2 30 17 31
  • 77.31 (n)
OneToMany
Gbp2b 31
  • 71 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 65 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 41 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves GBP 30
  • 54.33 (n)
-- 31
  • 51 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC398692 30
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-209n20.1 31
  • 42 (a)
ManyToMany
Species where no ortholog for GBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GBP2 Gene

ENSEMBL:
Gene Tree for GBP2 (if available)
TreeFam:
Gene Tree for GBP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GBP2: view image

Paralogs for GBP2 Gene

Paralogs for GBP2 Gene

(7) SIMAP similar genes for GBP2 Gene using alignment to 2 proteins:

  • GBP2_HUMAN
  • Q8TCE5_HUMAN
genes like me logo Genes that share paralogs with GBP2: view

Variants for GBP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GBP2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs386352304 Uncertain Significance: not provided 89,120,286(-) A/C
NM_004120.5(GBP2):c.321T>G (p.Gly107=)
SYNONYMOUS
rs1803632 - p.Pro285Ala
rs2230336 - p.Ser281Pro
rs2230338 - p.Ser303Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GBP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GBP2 Gene

Variant ID Type Subtype PubMed ID
esv3586753 CNV loss 21293372
nsv462494 CNV loss 19166990
nsv546796 CNV loss 21841781
nsv546797 CNV loss 21841781

Variation tolerance for GBP2 Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GBP2 Gene

Human Gene Mutation Database (HGMD)
GBP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GBP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP2 Gene

Disorders for GBP2 Gene

Additional Disease Information for GBP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for GBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GBP2 Gene

Publications for GBP2 Gene

  1. Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP. (PMID: 1715024) Cheng YS … Staeheli P (Molecular and cellular biology 1991) 2 3 4
  2. Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner. (PMID: 21151871) Britzen-Laurent N … Stürzl M (PloS one 2010) 3 4
  3. Guanylate-binding protein 2 mRNA in peripheral blood leukocytes of liver transplant recipients as a marker for acute cellular rejection. (PMID: 19912588) Kobayashi S … Mori M (Transplant international : official journal of the European Society for Organ Transplantation 2010) 3 23
  4. Interferon-inducible guanylate binding protein (GBP)-2: a novel p53-regulated tumor marker in esophageal squamous cell carcinomas. (PMID: 19003964) Guimarães DP … Hainaut P (International journal of cancer 2009) 3 23
  5. Unique features of different members of the human guanylate-binding protein family. (PMID: 17266443) Tripal P … Stürzl M (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007) 3 4

Products for GBP2 Gene

Sources for GBP2 Gene