Aliases for GBP2 Gene
External Ids for GBP2 Gene
Previous GeneCards Identifiers for GBP2 Gene
This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]
GeneCards Summary for GBP2 Gene
GBP2 (Guanylate Binding Protein 2) is a Protein Coding gene. Among its related pathways are Immune response IFN alpha/beta signaling pathway and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GBP3.
UniProtKB/Swiss-Prot Summary for GBP2 Gene
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).