GBP1 Gene (Protein Coding)

Guanylate Binding Protein 1

GC01M089052
GIFtS:
42
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008] See more...

Aliases for GBP1 Gene

Aliases for GBP1 Gene

  • Guanylate Binding Protein 1 2 3 5
  • Guanylate Binding Protein 1, Interferon-Inducible, 67kDa 2 3
  • Interferon-Induced Guanylate-Binding Protein 1 3 4
  • Guanine Nucleotide-Binding Protein 1 3 4
  • Guanylate-Binding Protein 1 3 4
  • GTP-Binding Protein 1 3 4
  • HuGBP-1 3 4
  • GBP-1 3 4
  • Guanylate Binding Protein 1, Interferon-Inducible 2
  • EC 3.6.5.- 4
  • GBP1 5

External Ids for GBP1 Gene

Previous GeneCards Identifiers for GBP1 Gene

  • GC01M089994
  • GC01M088687
  • GC01M088854
  • GC01M088985
  • GC01M088986
  • GC01M089230
  • GC01M089290
  • GC01M089517
  • GC01M087635

Summaries for GBP1 Gene

Entrez Gene Summary for GBP1 Gene

  • Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for GBP1 Gene

GBP1 (Guanylate Binding Protein 1) is a Protein Coding gene. Diseases associated with GBP1 include Chronic Active Epstein-Barr Virus Infection and Aneurysmal Bone Cysts. Among its related pathways are Innate Immune System and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and enzyme binding. An important paralog of this gene is GBP3.

UniProtKB/Swiss-Prot Summary for GBP1 Gene

  • Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.

Gene Wiki entry for GBP1 Gene

Additional gene information for GBP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GBP1 Gene

Genomics for GBP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GBP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J089063 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.7 705 3.3 CEBPB FOXA2 RXRA PRDM1 ZBTB33 TBP JUND BMI1 RAD21 REST GBP1 GBP3 GBP5 GBP7 PTGES3P1 lnc-GBP3-2 NONHSAG002014.2-001 LOC105378841 ENSG00000286802
GH01J089123 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 45.8 -61.2 -61225 7.2 CEBPA IRF2 CEBPB ARNT TRIM22 SAP130 EP300 TAL1 RXRA PRDM1 GBP2 LOC105378842 piR-31470-024 GBP1 GBP7 GBP5 GBP4 GBP3 ENSG00000237568 GTF2B
GH01J089269 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 62.7 -207.2 -207184 6.3 CEBPB EP300 RXRA MYC JUND MAX RAD21 ATF2 ATF4 HNF4A GBP5 MN296824 piR-30449-006 piR-39098-006 GBP1 GBP4 GBP2 GTF2B GBP3 LRRC8C
GH01J089284 Enhancer 1 FANTOM5 ENCODE dbSUPER 61.5 -221.1 -221080 3.4 MAFF ZNF316 BATF MAFK HNF4A MAFG JUNB MAX SP1 HNF4G GBP1 GBP5 GBP4 GBP2 GBP6 GTF2B LRRC8C GBP3 ENSG00000238081 HSALNG0005055
GH01J089309 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 52 -246.1 -246140 3.8 RXRA ZNF316 JUND NFE2 BATF NFE2L2 HNF4A ELF1 MAFG NR2F1 GBP1 GBP5 GBP4 GBP2 GTF2B PKN2 GBP3 ENSG00000231613 LRRC8C HSALNG0005057
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GBP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GBP1

Top Transcription factor binding sites by QIAGEN in the GBP1 gene promoter:
  • AML1a
  • CREB
  • deltaCREB
  • En-1
  • IRF-1
  • LCR-F1
  • POU2F1
  • POU2F1a

Genomic Locations for GBP1 Gene

Latest Assembly
chr1:89,051,882-89,065,360
(GRCh38/hg38)
Size:
13,479 bases
Orientation:
Minus strand

Previous Assembly
chr1:89,518,002-89,530,891
(GRCh37/hg19 by Entrez Gene)
Size:
12,890 bases
Orientation:
Minus strand

chr1:89,518,002-89,531,043
(GRCh37/hg19 by Ensembl)
Size:
13,042 bases
Orientation:
Minus strand

Genomic View for GBP1 Gene

Genes around GBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GBP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GBP1 Gene

Proteins for GBP1 Gene

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  • Protein details for GBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32455-GBP1_HUMAN
    Recommended name:
    Guanylate-binding protein 1
    Protein Accession:
    P32455
    Secondary Accessions:
    • D3DT26
    • Q5T8M1

    Protein attributes for GBP1 Gene

    Size:
    592 amino acids
    Molecular mass:
    67931 Da
    Quaternary structure:
    • Homodimer; homodimerization occurs upon GTP-binding and is required for the second hydrolysis step from GDP to GMP. Heterodimer with other family members, including GBP2, GBP3, GBP4 and GBP5. Dimerization regulates subcellular location to membranous structures.

    Three dimensional structures from OCA and Proteopedia for GBP1 Gene

neXtProt entry for GBP1 Gene

Protein Expression for GBP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GBP1 Gene

  • Isoprenylation is required for proper subcellular location.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GBP1 Gene

Domains & Families for GBP1 Gene

Gene Families for GBP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GBP1 Gene

InterPro:
Blocks:
  • Guanylate-binding protein
ProtoNet:

Suggested Antigen Peptide Sequences for GBP1 Gene

GenScript: Design optimal peptide antigens:
  • Guanine nucleotide-binding protein 1 (GBP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P32455

UniProtKB/Swiss-Prot:

GBP1_HUMAN :
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with GBP1: view

Function for GBP1 Gene

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  6. Cell Lines for research

Molecular function for GBP1 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; Evidence={ECO:0000269|PubMed:10676968, ECO:0000269|PubMed:16511497};.
UniProtKB/Swiss-Prot Induction:
By IFNG during macrophage activation, and by TNF and IL1B.
GENATLAS Biochemistry:
guanylate binding protein 1,67kDa,interferon inducibleGTPase converting GTP to GMP,mediating an antiviral effect against stomatites virus and encephalomyocarditis virus

Enzyme Numbers (IUBMB) for GBP1 Gene

Phenotypes From GWAS Catalog for GBP1 Gene

Gene Ontology (GO) - Molecular Function for GBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003779 actin binding IDA 24337748
GO:0003924 GTPase activity IEA,IDA 10676968
GO:0005515 protein binding IPI 21151871
GO:0005525 GTP binding IEA,IDA 10676968
genes like me logo Genes that share ontologies with GBP1: view
genes like me logo Genes that share phenotypes with GBP1: view

Animal Models for research

miRNA for GBP1 Gene

miRTarBase miRNAs that target GBP1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GBP1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GBP1 Gene

Localization for GBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GBP1 Gene

Cytoplasm. Golgi apparatus membrane. Lipid-anchor. Cytoplasmic side. Cell membrane. Secreted. Note=Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GBP1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
golgi apparatus 5
plasma membrane 4
nucleus 2
endoplasmic reticulum 2
endosome 2
lysosome 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA,IDA 17266443
GO:0005794 Golgi apparatus IEA,IDA 17266443
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GBP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GBP1 Gene

Pathways & Interactions for GBP1 Gene

genes like me logo Genes that share pathways with GBP1: view

Pathways by source for GBP1 Gene

1 BioSystems pathway for GBP1 Gene
1 KEGG pathway for GBP1 Gene

Gene Ontology (GO) - Biological Process for GBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0032703 negative regulation of interleukin-2 production IMP 24337748
GO:0050848 regulation of calcium-mediated signaling IMP 24337748
GO:0050860 negative regulation of T cell receptor signaling pathway IMP 24337748
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with GBP1: view

No data available for SIGNOR curated interactions for GBP1 Gene

Drugs & Compounds for GBP1 Gene

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(2) Drugs for GBP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for GBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GBP1: view

Transcripts for GBP1 Gene

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mRNA/cDNA for GBP1 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GBP1

Alternative Splicing Database (ASD) splice patterns (SP) for GBP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for GBP1 Gene

GeneLoc Exon Structure for
GBP1

Expression for GBP1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GBP1 Gene

mRNA expression in normal human tissues for GBP1 Gene
mRNA expression by BioGPS for GBP1 GenemRNA expression by GTEx for GBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GBP1 Gene

This gene is overexpressed in Spleen (24.7) and Oral epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GBP1 Gene



Protein tissue co-expression partners for GBP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GBP1

SOURCE GeneReport for Unigene cluster for GBP1 Gene:

Hs.62661

Evidence on tissue expression from TISSUES for GBP1 Gene

  • Lung(3.8)
  • Nervous system(3.5)
  • Blood(3)
  • Liver(2.8)
  • Lymph node(2.8)
  • Spleen(2.8)
  • Intestine(2.8)
  • Kidney(2.4)
  • Heart(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with GBP1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GBP1 Gene

Orthologs for GBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GBP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GBP1 30 31
  • 99.04 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia LOC512486 30
  • 85.07 (n)
-- 31
  • 82 (a)
 ManyToMany
Dog
(Canis familiaris)
 Mammalia GBP1 30
  • 84.29 (n)
-- 31
  • 80 (a)
 OneToMany
Rat
(Rattus norvegicus)
 Mammalia Gbp1 30
  • 78.73 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 60 (a)
 ManyToMany
Chicken
(Gallus gallus)
 Aves GBP7 30
  • 59.46 (n)
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia Str.10068 30
Zebrafish
(Danio rerio)
 Actinopterygii si:ch211-209n20.1 30 31
  • 59.24 (n)
 ManyToMany
Species where no ortholog for GBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GBP1 Gene

ENSEMBL:
Gene Tree for GBP1 (if available)
TreeFam:
Gene Tree for GBP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GBP1: view image

Paralogs for GBP1 Gene

Paralogs for GBP1 Gene

(7) SIMAP similar genes for GBP1 Gene using alignment to 1 proteins:

  • GBP1_HUMAN

Pseudogenes.org Pseudogenes for GBP1 Gene

genes like me logo Genes that share paralogs with GBP1: view

Variants for GBP1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GBP1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1048401 - p.Ile78Val
rs1048425 - p.Thr349Ser
rs1048443 - p.Ala409Gly
rs17130717 - p.Glu166Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GBP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GBP1 Gene

Variant ID Type Subtype PubMed ID
esv2758948 CNV gain 17122850
esv33356 CNV loss 17666407
nsv546796 CNV loss 21841781
nsv946056 CNV duplication 23825009
nsv946057 CNV duplication 23825009
nsv946059 CNV duplication 23825009
nsv946060 CNV duplication 23825009

Variation tolerance for GBP1 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GBP1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GBP1 Gene

Disorders for GBP1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GBP1 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search GBP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GBP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GBP1 Gene

Publications for GBP1 Gene

  1. Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis. (PMID: 16936281) Naschberger E … Stürzl M (The American journal of pathology 2006) 3 4 23
  2. Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor. (PMID: 15937107) Modiano N … Cresswell P (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 23
  3. Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. (PMID: 10676968) Prakash B … Herrmann C (Nature 2000) 3 4 23
  4. Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1. (PMID: 8830800) Nantais DE … Buss JE (Journal of leukocyte biology 1996) 3 4 23
  5. The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1. (PMID: 7518790) Strehlow I … Decker T (Gene 1994) 2 3 23

ExternalLinks

View latest publications for GBP1 gene in Mastermind

Products for GBP1 Gene

  • Addgene plasmids for GBP1

Sources for GBP1 Gene