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Aliases for GATD3B Gene

Aliases for GATD3B Gene

  • Glutamine Amidotransferase Like Class 1 Domain Containing 3B 2 3 5
  • Glutamine Amidotransferase-Like Class 1 Domain-Containing Protein 3B, Mitochondrial 3 4
  • Keio Novel Protein-I 3 4
  • KNP-I 3 4
  • ES1 Protein Homolog, Mitochondrial 3
  • Uncharacterized Protein GATD3B 3
  • Protein GT335 4
  • Protein HES1 4
  • HES1 4
  • KNPI 4

External Ids for GATD3B Gene

Summaries for GATD3B Gene

GeneCards Summary for GATD3B Gene

GATD3B (Glutamine Amidotransferase Like Class 1 Domain Containing 3B) is a Protein Coding gene. Among its related pathways are Gastric Cancer Network 1. An important paralog of this gene is GATD3A.

Additional gene information for GATD3B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GATD3B Gene

Genomics for GATD3B Gene

GeneHancer (GH) Regulatory Elements for GATD3B Gene

Promoters and enhancers for GATD3B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J005127 Promoter 0.5 Ensembl 600.7 +0.4 350 3.4 GATD3B ENSG00000276612 LOC101928576
GH21J005110 Enhancer 0.2 Ensembl 0.4 +17.6 17550 1 LOC101928576 GATD3B
GH21J005082 Enhancer 0.2 Ensembl 0.3 +46.0 45950 0.6 ENSG00000279687 CH507-9B2.8 LOC101928576 GATD3B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GATD3B on UCSC Golden Path with GeneCards custom track

Genomic Locations for GATD3B Gene

Genomic Locations for GATD3B Gene
chr21:5,079,294-5,128,451
(GRCh38/hg38)
Size:
49,158 bases
Orientation:
Minus strand

Genomic View for GATD3B Gene

Genes around GATD3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GATD3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GATD3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GATD3B Gene

Proteins for GATD3B Gene

  • Protein details for GATD3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0B4J2D5-GAL3B_HUMAN
    Recommended name:
    Glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial
    Protein Accession:
    A0A0B4J2D5
    Secondary Accessions:
    • A6NFJ6
    • A6NJY7
    • O00650
    • O00660
    • O15011
    • O15012
    • P30042
    • P55346
    • P78474
    • Q92505
    • Q92507

    Protein attributes for GATD3B Gene

    Size:
    268 amino acids
    Molecular mass:
    28142 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GATD3B Gene

neXtProt entry for GATD3B Gene

Post-translational modifications for GATD3B Gene

No Post-translational modifications

No data available for DME Specific Peptides for GATD3B Gene

Domains & Families for GATD3B Gene

Gene Families for GATD3B Gene

Protein Domains for GATD3B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A0A0B4J2D5

UniProtKB/Swiss-Prot:

GAL3B_HUMAN :
  • Belongs to the GATD3 family.
Family:
  • Belongs to the GATD3 family.
genes like me logo Genes that share domains with GATD3B: view

No data available for Suggested Antigen Peptide Sequences for GATD3B Gene

Function for GATD3B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GATD3B Gene

Localization for GATD3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GATD3B Gene

Mitochondrion.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GATD3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with GATD3B: view

No data available for Subcellular locations from COMPARTMENTS for GATD3B Gene

Pathways & Interactions for GATD3B Gene

PathCards logo

SuperPathways for GATD3B Gene

SuperPathway Contained pathways
1 Gastric Cancer Network 1
genes like me logo Genes that share pathways with GATD3B: view

Pathways by source for GATD3B Gene

1 BioSystems pathway for GATD3B Gene

Interacting Proteins for GATD3B Gene

STRING Interaction Network Preview (showing top 4 STRING interactants - click image to see details)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000480313%0d9606.ENSP00000291577%0d9606.ENSP00000362987%0d9606.ENSP00000477341%0d9606.ENSP00000356988%0d
Selected Interacting proteins: ENSP00000480313 for GATD3B Gene via STRING

Gene Ontology (GO) - Biological Process for GATD3B Gene

None

No data available for SIGNOR curated interactions for GATD3B Gene

Drugs & Compounds for GATD3B Gene

No Compound Related Data Available

Transcripts for GATD3B Gene

mRNA/cDNA for GATD3B Gene

(3) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GATD3B Gene

No ASD Table

Relevant External Links for GATD3B Gene

GeneLoc Exon Structure for
GATD3B
ECgene alternative splicing isoforms for
GATD3B

Expression for GATD3B Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GATD3B Gene

Orthologs for GATD3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GATD3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C21H21orf33 34
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia C31H21orf33 34
  • 84.4 (n)
mouse
(Mus musculus)
Mammalia D10Jhu81e 34
  • 83.08 (n)
Gatd3a 17
rat
(Rattus norvegicus)
Mammalia RGD1303003 34
  • 82.83 (n)
cow
(Bos Taurus)
Mammalia C1H21orf33 34
  • 82.12 (n)
chicken
(Gallus gallus)
Aves C1H21ORF33 34
  • 73.86 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia c21orf33 34
  • 69.66 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:112056 34
  • 73.14 (n)
Species where no ortholog for GATD3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GATD3B Gene

ENSEMBL:
Gene Tree for GATD3B (if available)
TreeFam:
Gene Tree for GATD3B (if available)

Paralogs for GATD3B Gene

Paralogs for GATD3B Gene

genes like me logo Genes that share paralogs with GATD3B: view

Variants for GATD3B Gene

Sequence variations from dbSNP and Humsavar for GATD3B Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1156281125 -- 5,113,332(-) C/T genic_downstream_transcript_variant, intron_variant
rs1156407585 -- 5,112,112(-) G/C genic_downstream_transcript_variant, intron_variant
rs1156520100 -- 5,110,659(-) T/C genic_downstream_transcript_variant, intron_variant
rs1156593996 -- 5,128,016(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1156686322 -- 5,125,998(-) C/A/T intron_variant

Additional Variant Information for GATD3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GATD3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for GATD3B Gene

Disorders for GATD3B Gene

Additional Disease Information for GATD3B

No disorders were found for GATD3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GATD3B Gene

Publications for GATD3B Gene

  1. Isolation of cDNA for a novel human protein KNP-I that is homologous to the E. coli SCRP-27A protein from the autoimmune polyglandular disease type I (APECED) region of chromosome 21q22.3. (PMID: 8753807) Nagamine K … Shimizu N (Biochemical and biophysical research communications 1996) 3 4 58
  2. Isolation and characterization of GT335, a novel human gene conserved in Escherichia coli and mapping to 21q22.3. (PMID: 8975701) Lafrenière RG … Rouleau GA (Genomics 1996) 3 4 58
  3. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 58

Products for GATD3B Gene

Sources for GATD3B Gene

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