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GATC (Glutamyl-TRNA Amidotransferase Subunit C) is a Protein Coding gene. Among its related pathways are tRNA Aminoacylation and Metabolism. Gene Ontology (GO) annotations related to this gene include glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. An important paralog of this gene is ENSG00000111780.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 19805282 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016874 | ligase activity | IEA | -- |
GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor | IEA | -- |
GO:0050567 | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity | IDA,IEA | 19805282 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IDA,IEA | 19805282 |
GO:0030956 | glutamyl-tRNA(Gln) amidotransferase complex | IEA,IDA | 19805282 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | tRNA Aminoacylation | ||
2 | Metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006412 | translation | IEA | -- |
GO:0006450 | regulation of translational fidelity | IEA | -- |
GO:0032543 | mitochondrial translation | IMP | 19805282 |
GO:0070681 | glutaminyl-tRNAGln biosynthesis via transamidation | IEA,IDA | 19805282 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Phosphoric acid | Approved | Pharma | 0 | |||
Glutamic acid | Approved | Nutra | Full agonist, Agonist | 281 | ||
L-Glutamine | Approved, Investigational | Nutra | Full agonist, Agonist | 0 | ||
ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GATC 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | GATC 33 32 |
|
OneToMany | |
dog (Canis familiaris) |
Mammalia | GATC 33 32 |
|
OneToMany | |
rat (Rattus norvegicus) |
Mammalia | Gatc 32 |
|
||
mouse (Mus musculus) |
Mammalia | Gatc 17 33 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
chicken (Gallus gallus) |
Aves | GATC 32 |
|
||
-- 33 |
|
OneToMany | |||
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | gatc 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | si:rp71-1c23.3 32 |
|
||
GATC 33 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP013093 32 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG33649 33 32 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | Y66D12A.7 33 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1370579526 | pathogenic, Cardiomyopathy, mitochondrial | 120,446,808(+) | T/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs1131691323 | uncertain-significance, not provided | 120,457,131(+) | C/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs1000029821 | -- | 120,457,848(+) | C/T | intron_variant | |
rs1000354719 | -- | 120,451,717(+) | G/A | intron_variant | |
rs1000760678 | -- | 120,447,486(+) | C/A/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3630923 | CNV | gain | 21293372 |
esv3630924 | CNV | loss | 21293372 |
nsv509482 | CNV | insertion | 20534489 |
nsv983369 | CNV | duplication | 23825009 |
nsv983370 | CNV | duplication | 23825009 |
No disorders were found for GATC Gene.