Aliases for GATAD2A Gene

Aliases for GATAD2A Gene

  • GATA Zinc Finger Domain Containing 2A 2 3 5
  • GATA Zinc Finger Domain-Containing Protein 2A 3 4
  • Transcriptional Repressor P66-Alpha 3 4
  • P66alpha 2 3
  • P66 Alpha 2
  • Hp66alpha 4
  • GATAD2A 5

External Ids for GATAD2A Gene

Previous GeneCards Identifiers for GATAD2A Gene

  • GC19P019238
  • GC19P019431
  • GC19P019399
  • GC19P019496
  • GC19P019058
  • GC19P020509
  • GC19P020648
  • GC19P020756
  • GC19P022266
  • GC19P019400
  • GC19P019578
  • GC19P019686
  • GC19P020058
  • GC19P020367
  • GC19P023337
  • GC19P024476

Summaries for GATAD2A Gene

GeneCards Summary for GATAD2A Gene

GATAD2A (GATA Zinc Finger Domain Containing 2A) is a Protein Coding gene. Diseases associated with GATAD2A include Cockayne Syndrome. Among its related pathways are Chromatin organization and Signaling events mediated by HDAC Class I. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein binding, bridging. An important paralog of this gene is GATAD2B.

UniProtKB/Swiss-Prot Summary for GATAD2A Gene

  • Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GATAD2A Gene

Genomics for GATAD2A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GATAD2A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GATAD2A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GATAD2A

Top Transcription factor binding sites by QIAGEN in the GATAD2A gene promoter:
  • c-Ets-1
  • Elk-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Msx-1
  • Olf-1
  • p300
  • POU2F1
  • POU2F1a
  • Spz1

Genomic Locations for GATAD2A Gene

Latest Assembly
123,107 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
123,090 bases
Plus strand

(GRCh37/hg19 by Ensembl)
123,106 bases
Plus strand

Genomic View for GATAD2A Gene

Genes around GATAD2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GATAD2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GATAD2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GATAD2A Gene

Proteins for GATAD2A Gene

  • Protein details for GATAD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcriptional repressor p66-alpha
    Protein Accession:
    Secondary Accessions:
    • B5MC40
    • Q7L3J2
    • Q96F28
    • Q9NPU2
    • Q9NXS1

    Protein attributes for GATAD2A Gene

    633 amino acids
    Molecular mass:
    68063 Da
    Quaternary structure:
    • Interacts with MBD2 and MBD3 (PubMed:12183469, PubMed:16415179, PubMed:21490301). Interaction with MBD2 is required for the enhancement of MBD2-mediated repression and for targeting to the chromatin (PubMed:12183469, PubMed:16415179, PubMed:21490301). Component of the MeCP1 histone deacetylase complex (PubMed:21490301). Interacts with histone tails, including that of histones H2A, H2B, H3 and H4 (PubMed:16415179). This interaction is reduced by histone acetylation (PubMed:16415179). Interacts with ERCC6 (PubMed:26030138).
    • Sequence=AAH11684.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA90939.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GATAD2A Gene

    Alternative splice isoforms for GATAD2A Gene


neXtProt entry for GATAD2A Gene

Post-translational modifications for GATAD2A Gene

  • Ubiquitination at Lys464
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GATAD2A Gene

Domains & Families for GATAD2A Gene

Gene Families for GATAD2A Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for GATAD2A Gene

  • Zn-finger, GATA type

Suggested Antigen Peptide Sequences for GATAD2A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55704, highly similar to Transcriptional repressor p66 alpha (B4DKZ7_HUMAN)
  • GATA zinc finger domain-containing protein 2A (P66A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Both CR1 and CR2 regions are required for speckled nuclear localization.
  • Both CR1 and CR2 regions are required for speckled nuclear localization.
genes like me logo Genes that share domains with GATAD2A: view

Function for GATAD2A Gene

Molecular function for GATAD2A Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.

Phenotypes From GWAS Catalog for GATAD2A Gene

Gene Ontology (GO) - Molecular Function for GATAD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12183469
GO:0008270 zinc ion binding IEA --
GO:0030674 protein binding, bridging IDA 12183469
GO:0043565 sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GATAD2A: view
genes like me logo Genes that share phenotypes with GATAD2A: view

Animal Models for GATAD2A Gene

MGI Knock Outs for GATAD2A:

miRNA for GATAD2A Gene

miRTarBase miRNAs that target GATAD2A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GATAD2A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GATAD2A Gene

Localization for GATAD2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GATAD2A Gene

Nucleus speckle. Note=Speckled nuclear localization requires both CR1 and CR2 regions. {ECO:0000269 PubMed:16415179}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GATAD2A gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GATAD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12183469
GO:0005654 nucleoplasm IDA --
GO:0016581 NuRD complex IBA,IDA 12183469
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with GATAD2A: view

Pathways & Interactions for GATAD2A Gene

genes like me logo Genes that share pathways with GATAD2A: view

Pathways by source for GATAD2A Gene

1 GeneGo (Thomson Reuters) pathway for GATAD2A Gene
  • Transcription Sin3 and NuRD in transcription regulation

Gene Ontology (GO) - Biological Process for GATAD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006306 DNA methylation TAS 12183469
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 12183469
genes like me logo Genes that share ontologies with GATAD2A: view

No data available for SIGNOR curated interactions for GATAD2A Gene

Drugs & Compounds for GATAD2A Gene

No Compound Related Data Available

Transcripts for GATAD2A Gene

mRNA/cDNA for GATAD2A Gene

17 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GATAD2A

Alternative Splicing Database (ASD) splice patterns (SP) for GATAD2A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
SP1: - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - -
SP10: - -
SP11: -
SP12: -
SP13: -

ExUns: 18b ^ 19a · 19b

Relevant External Links for GATAD2A Gene

GeneLoc Exon Structure for

Expression for GATAD2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GATAD2A Gene

Protein differential expression in normal tissues from HIPED for GATAD2A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.5) and CD8 Tcells (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GATAD2A Gene

Protein tissue co-expression partners for GATAD2A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GATAD2A

SOURCE GeneReport for Unigene cluster for GATAD2A Gene:


mRNA Expression by UniProt/SwissProt for GATAD2A Gene:

Tissue specificity: Ubiquitous, both in fetal and adult tissues.

Evidence on tissue expression from TISSUES for GATAD2A Gene

  • Nervous system(4.7)
  • Intestine(4.6)
  • Skin(4.6)
  • Liver(4.4)
  • Lung(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with GATAD2A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GATAD2A Gene

Orthologs for GATAD2A Gene

This gene was present in the common ancestor of animals.

Orthologs for GATAD2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GATAD2A 29 30
  • 99.32 (n)
(Bos Taurus)
Mammalia GATAD2A 29 30
  • 89.8 (n)
(Canis familiaris)
Mammalia GATAD2A 29 30
  • 89.7 (n)
(Rattus norvegicus)
Mammalia Gatad2a 29
  • 84.98 (n)
(Mus musculus)
Mammalia Gatad2a 29 16 30
  • 84.29 (n)
(Ornithorhynchus anatinus)
Mammalia GATAD2A 30
  • 81 (a)
(Monodelphis domestica)
Mammalia GATAD2A 30
  • 78 (a)
(Gallus gallus)
Aves GATAD2A 29 30
  • 72.52 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gatad2a 29
  • 68.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398154 29
(Danio rerio)
Actinopterygii gatad2ab 29 30
  • 62.71 (n)
nszf-a189 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9074 29
Fruit Fly
(Drosophila melanogaster)
Insecta simj 30
  • 19 (a)
(Caenorhabditis elegans)
Secernentea dcp-66 30
  • 16 (a)
Species where no ortholog for GATAD2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GATAD2A Gene

Gene Tree for GATAD2A (if available)
Gene Tree for GATAD2A (if available)
Evolutionary constrained regions (ECRs) for GATAD2A: view image
Alliance of Genome Resources:
Additional Orthologs for GATAD2A

Paralogs for GATAD2A Gene

Paralogs for GATAD2A Gene

(1) SIMAP similar genes for GATAD2A Gene using alignment to 12 proteins:

  • P66A_HUMAN
  • F5H7D9_HUMAN
  • H7C3H1_HUMAN
  • V9GY85_HUMAN
genes like me logo Genes that share paralogs with GATAD2A: view

Variants for GATAD2A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GATAD2A Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs112281927 Benign: not provided 19,501,404(+) C/T
NM_001300946.2(GATAD2A):c.1491C>T (p.Pro497=)
rs10426883 -- p.Arg17Gln
rs2288851 -- p.Asn296Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GATAD2A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GATAD2A Gene

Variant ID Type Subtype PubMed ID
esv3583269 CNV loss 25503493
nsv1056419 CNV gain 25217958
nsv1144871 CNV deletion 24896259

Variation tolerance for GATAD2A Gene

Residual Variation Intolerance Score: 5.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GATAD2A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GATAD2A Gene

Disorders for GATAD2A Gene

MalaCards: The human disease database

(1) MalaCards diseases for GATAD2A Gene - From: COP and GCD

Disorder Aliases PubMed IDs
cockayne syndrome
  • cockayne's syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GATAD2A

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GATAD2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GATAD2A Gene

Publications for GATAD2A Gene

  1. Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3. (PMID: 12183469) Brackertz M … Renkawitz R (The Journal of biological chemistry 2002) 2 3 4 22
  2. Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics. (PMID: 26030138) Nicolai S … Proietti-De-Santis L (PloS one 2015) 3 4
  3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 40
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
  5. p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction. (PMID: 16415179) Brackertz M … Renkawitz R (Nucleic acids research 2006) 3 4

Products for GATAD2A Gene

Sources for GATAD2A Gene