Aliases for GATA5 Gene
External Ids for GATA5 Gene
Previous GeneCards Identifiers for GATA5 Gene
The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008]
GeneCards Summary for GATA5 Gene
GATA5 (GATA Binding Protein 5) is a Protein Coding gene. Diseases associated with GATA5 include Congenital Heart Defects, Multiple Types, 5 and Aortic Valve Disease 1. Among its related pathways are DREAM Repression and Dynorphin Expression and Factors involved in megakaryocyte development and platelet production. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is GATA4.
UniProtKB/Swiss-Prot Summary for GATA5 Gene
Transcription factor required during cardiovascular development (PubMed:23289003). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (PubMed:25543888).