Aliases for GATA3 Gene
Aliases for GATA3 Gene
External Ids for GATA3 Gene
- HGNC: 4172
- Entrez Gene: 2625
- Ensembl: ENSG00000107485
- OMIM: 131320
- UniProtKB: P23771
Previous GeneCards Identifiers for GATA3 Gene
- GC10P008040
- GC10P008246
- GC10P008100
- GC10P008136
- GC10P008015
- GC10P008095
Summaries for GATA3 Gene
-
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
GeneCards Summary for GATA3 Gene
GATA3 (GATA Binding Protein 3) is a Protein Coding gene. Diseases associated with GATA3 include Hypoparathyroidism, Sensorineural Deafness, And Renal Disease and Hypoparathyroidism. Among its related pathways are Development IGF-1 receptor signaling and C-MYB transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is GATA2.
UniProtKB/Swiss-Prot for GATA3 Gene
-
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5-AGATAG-3. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.
Additional gene information for GATA3 Gene
- Monarch Initiative
- Search for GATA3 at DataMed
- Search for GATA3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GATA3 Gene
Genomics for GATA3 Gene
GeneHancer (GH) Regulatory Elements for GATA3 Gene
Promoters and enhancers for GATA3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GATA3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GATA3 gene promoter:
Regulatory Element Products
Genomic Locations for GATA3 Gene
Genomic Locations for GATA3 Gene
- chr10:8,045,378-8,075,203
- (GRCh38/hg38)
- Size:
- 29,826 bases
- Orientation:
- Plus strand
- chr10:8,095,567-8,117,164
- (GRCh37/hg19)
Genomic View for GATA3 Gene
Genes around GATA3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p14 by Entrez Gene
- 10p14 by HGNC
- 10p14 by Ensembl
GATA3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GATA3 Gene
Proteins for GATA3 Gene
-
Protein details for GATA3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P23771-GATA3_HUMAN
- Recommended name:
- Trans-acting T-cell-specific transcription factor GATA-3
- Protein Accession:
- P23771
- Q5VWG7
- Q5VWG8
- Q96J16
Protein attributes for GATA3 Gene
- Size:
- 443 amino acids
- Molecular mass:
- 47916 Da
- Quaternary structure:
-
- Interacts with TBX21 (Tyr-530 phosphorylated form).
Protein Expression for GATA3 Gene
Post-translational modifications for GATA3 Gene
Other Protein References for GATA3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for GATA3 (GATA-3)
-
Custom Antibody ServicesOriGene Antibodies for GATA3
- Novus Biologicals Antibodies for GATA3
- Invitrogen Antibodies for GATA3
- antibodies-online: Search results for 230 available GATA3 Antibodies ranked by validation data
- Compare Top GATA3 Antibodies
-
Recommended
- 160 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 17 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 73 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 14 FACS Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 40 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- GeneTex GATA3 Antibody for GATA3
-
Custom Antibody ServicesProSci Antibodies for GATA3
-
Santa Cruz Biotechnology (SCBT) Antibodies for GATA3
- Sino Biological Antibodies for GATA3
Protein Products
-
OriGene Purified Proteins for GATA3
- Search Origene for MassSpec and Protein Over-expression Lysates for GATA3
- Origene Custom Protein Services for GATA3
- Search GeneTex for Proteins for GATA3
Assay Products
No data available for DME Specific Peptides for GATA3 Gene
Domains & Families for GATA3 Gene
Gene Families for GATA3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for GATA3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GATA3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P23771UniProtKB/Swiss-Prot:
GATA3_HUMAN :- Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation.
- Domain:
-
- Binds DNA via the 2 GATA-type zinc fingers. Each zinc finger may bind either adjacent sites in a palindromic motif, or a different DNA molecule allowing looping and long-range gene regulation.
- The YxKxHxxxRP motif is critical for DNA-binding and function.
Function for GATA3 Gene
Molecular function for GATA3 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5-AGATAG-3. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.
- GENATLAS Biochemistry:
- T cell specific transcription factor,GATA sequence binding protein in T cell receptor,also expressed in endothelial cell,placenta,transcriptional regulator in kidney,adrenal gland,embryonic brain,adult nervous system endocardium,associated with a special class of nuclear bodies
Phenotypes From GWAS Catalog for GATA3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 19723756 |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | -- |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0000987 | proximal promoter sequence-specific DNA binding | IDA | 19232384 |
Phenotypes for GATA3 Gene
- MGI mutant phenotypes for GATA3:
-
inferred from 13 alleles
- cardiovascular system phenotype
- pigmentation phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- no phenotypic analysis
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for GATA3:
Animal Models for GATA3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GATA3
-
CRISPR Products
-
OriGene CRISPR knockouts for GATA3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GATA3
- genomics-online: gRNA clones - Search results for 121 available GATA3 gene related products
- Overview of 121 available GATA3 gene related products
- Applied Biological Materials CRISPR for GATA3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GATA3
- GenScript: Design CRISPR guide RNA sequences for GATA3
miRNA for GATA3 Gene
- miRTarBase miRNAs that target GATA3
Targeted motifs for GATA3 Gene
HOMER Transcription Factor Regulatory Elements motif GATA3
- Consensus sequence: AGATAASR Submotif: canonical Cell Type: iTreg GEO ID: GSE20898
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GATA3
- Browse OriGene Inhibitory RNA Products For GATA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GATA3
- genomics-online: shRNA clones - Search results for 121 available GATA3 gene related products
- Overview of 121 available GATA3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GATA3
- VectorBuilder custom plasmid, inducible vectors for GATA3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GATA3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GATA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GATA3
- Applied Biological Materials Clones for GATA3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GATA3
No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for GATA3 Gene
Localization for GATA3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GATA3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA | 20855495 |
| GO:0005634 | nucleus | IDA | 19674970 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IBA | -- |
Pathways & Interactions for GATA3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Th17 cell differentiation | ||
| 2 | Th1 Differentiation Pathway | ||
| 3 | Cytokine Signaling in Immune system | ||
| 4 | Deubiquitination |
.74
|
|
| 5 | Metabolism of proteins | ||
Pathways by source for GATA3 Gene
14 BioSystems pathways for GATA3 Gene
10 Reactome pathways for GATA3 Gene
4 KEGG pathways for GATA3 Gene
1 GeneGo (Thomson Reuters) pathway for GATA3 Gene
3 R&D Systems pathways for GATA3 Gene
2 Qiagen pathways for GATA3 Gene
1 Cell Signaling Technology pathway for GATA3 Gene
Interacting Proteins for GATA3 Gene
Selected Interacting proteins:
P23771-GATA3_HUMAN
ENSP00000368632
for GATA3 Gene via
IID
UniProtKB
MINT
STRING
GPS-Prot Interaction Network for GATA3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001709 | cell fate determination | ISS | -- |
| GO:0001764 | neuron migration | IEA | -- |
Drugs & Compounds for GATA3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Agonist | Anti-inflammatory glucocorticoid | 2314 | |
| Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3113 | ||
| Cytarabine | Approved, Investigational | Pharma | 1166 | |||
| Daunorubicin | Approved | Pharma | DNA topoisomerase II inhibitor | 291 | ||
| Doxorubicin | Approved, Investigational | Pharma | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 1828 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for GATA3 Gene
mRNA/cDNA for GATA3 Gene
- (166) Selected AceView cDNA sequences:
- (8) Additional mRNA sequences :
- (4) REFSEQ mRNAs :
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000346208 2650 bps (uc001ika.4)
- ENST00000379328 3123 bps (uc001ijz.4)
- ENST00000461472 895 bps (uc057rpl.1)
- ENST00000481743 975 bps (uc057rpk.1)
- ENST00000643001 748 bps
Unigene Clusters for GATA3 Gene
- GATA binding protein 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for GATA3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GATA3
- genomics-online: gRNA clones - Search results for 121 available GATA3 gene related products
- Overview of 121 available GATA3 gene related products
- Applied Biological Materials CRISPR for GATA3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GATA3
- GenScript: Design CRISPR guide RNA sequences for GATA3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GATA3
- Browse OriGene Inhibitory RNA Products For GATA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GATA3
- genomics-online: shRNA clones - Search results for 121 available GATA3 gene related products
- Overview of 121 available GATA3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GATA3
- VectorBuilder custom plasmid, inducible vectors for GATA3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GATA3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GATA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GATA3
- Applied Biological Materials Clones for GATA3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||
| SP2: | |||||||||||||||
| SP3: | - |
Expression for GATA3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Fetal Inner Root Sheath Cells Inner Root Sheath
- Inner Root Sheath Cuticle Cells Inner Root Sheath
- Outer Root Sheath Progenitor Cells Embryonic Epidermis
- Inner Root Sheath Huxley Cells Inner Root Sheath
- Inner Root Sheath Progenitor Cells Inner Root Sheath
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Hematopoietic Stem Cells Liver Bud
- Common Lymphoid Progenitor Cells Hematopoietic Bone Marrow
-
Epithelial Cells
- Fetal Inner Root Sheath Cells Inner Root Sheath
- Inner Root Sheath Progenitor Cells Inner Root Sheath
-
Trophoblast (Extraembryonic Tissues)
- Trophoblast Cells Trophoblast
- Mural Trophectoderm Cells Mural Trophectoderm
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Epidermis (Integumentary System)
- Outer Root Sheath Progenitor Cells Embryonic Epidermis
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
- Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for GATA3 Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.6), Skin - Not Sun Exposed (Suprapubic) (x15.0), Bladder (x7.0), and Breast - Mammary Tissue (x4.2).
This gene is overexpressed in Placenta (64.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GATA3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GATA3 Gene:
GATA3SOURCE GeneReport for Unigene cluster for GATA3 Gene:
Hs.524134mRNA Expression by UniProt/SwissProt for GATA3 Gene:
P23771-GATA3_HUMAN
Tissue specificity:
T-cells and endothelial cells.
Evidence on tissue expression from TISSUES for GATA3 Gene
- Blood(4.6)
- Skin(3)
- Spleen(2.7)
- Lymph node(2.5)
- Kidney(2.3)
- Lung(2.3)
- Nervous system(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for GATA3 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- ear
- eye
- head
- jaw
- larynx
- mandible
- maxilla
- mouth
- neck
- skull
Thorax:
- chest wall
- clavicle
- heart
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- kidney
Pelvis:
- pelvis
- ureter
- urinary bladder
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- coagulation system
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs and template standards for GATA3
-
OriGene qPCR primer pairs for GATA3
Gene Expression Assay Products
Orthologs for GATA3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GATA3 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GATA3 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GATA3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GATA3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gata3 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gata3 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GATA3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GATA3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GATA3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gata3 33 |
|
||
| Str.10665 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.793 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gata3 34 33 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | pnr 35 |
|
|
|
| grn 34 35 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | elt-1 34 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DAL80 34 |
|
ManyToMany | |
| GAT1 34 |
|
ManyToMany | |||
| GZF3 34 |
|
ManyToMany | |||
| GLN3 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for GATA3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for GATA3 Gene
- ENSEMBL:
- Gene Tree for GATA3 (if available)
- TreeFam:
- Gene Tree for GATA3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GATA3: view image
Paralogs for GATA3 Gene
Variants for GATA3 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs104886016 | not-provided, Neoplasm of ovary | 8,069,457(+) | C/T | intron_variant | |
| rs104886017 | not-provided, Familial cancer of breast | 8,069,580(+) | C/T | coding_sequence_variant, synonymous_variant | |
| rs104894162 | pathogenic, Barakat syndrome | 8,064,043(+) | C/T | coding_sequence_variant, stop_gained | |
| rs104894163 | pathogenic, Barakat syndrome, Hypoparathyroidism, sensorineural deafness, and renal disease (HDR) [MIM:146255] | 8,064,037(+) | T/A | coding_sequence_variant, missense_variant | |
| rs104894164 | pathogenic, Barakat syndrome | 8,073,787(+) | C/T | coding_sequence_variant, stop_gained |
Residual Variation Intolerance Score:
18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.73;
15.52% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GATA3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GATA3 Gene
Disorders for GATA3 Gene
(36) MalaCards diseases for GATA3 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypoparathyroidism, sensorineural deafness, and renal disease |
|
|
| hypoparathyroidism |
|
|
| renal dysplasia |
|
|
| bartholin's duct cyst |
|
|
| danubian endemic familial nephropathy |
|
|
Search GATA3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GATA3_HUMAN- Hypoparathyroidism, sensorineural deafness, and renal disease (HDR) [MIM:146255]: A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia. {ECO:0000269 PubMed:10935639, ECO:0000269 PubMed:11389161, ECO:0000269 PubMed:26514990}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for GATA3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for GATA3 Gene
Publications for GATA3 Gene
- No evidence that GATA3 rs570613 SNP modifies breast cancer risk. (PMID: 19082709) Johnatty SE … Breast Cancer Association Consortium and Consortium of Investigators of Modifiers of BRCA1/2 (Breast cancer research and treatment 2009) 3 22 44 58
- Association of single nucleotide polymorphisms in GATA-3 with allergic rhinitis. (PMID: 18607915) Zhang L … Zhao Y (Acta oto-laryngologica 2009) 3 22 44 58
- Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood. (PMID: 18410415) Arshad SH … Ewart S (The British journal of dermatology 2008) 3 22 44 58
- Patterns of GATA3 and IL13 gene polymorphisms associated with childhood rhinitis and atopy in a birth cohort. (PMID: 18037162) Huebner M … Arshad SH (The Journal of allergy and clinical immunology 2008) 3 22 44 58
- Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor status. (PMID: 18006915) Garcia-Closas M … Perou CM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007) 3 22 44 58
Products for GATA3 Gene
- R&D Systems Antibodies for GATA3 (GATA-3)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for GATA3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GATA3
- Search Origene for MassSpec and Protein Over-expression Lysates for GATA3
- Origene Custom Protein Services for GATA3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GATA3
- Browse OriGene Inhibitory RNA Products For GATA3
- OriGene qPCR primer pairs and template standards for GATA3
- OriGene qPCR primer pairs for GATA3
- OriGene CRISPR knockouts for GATA3
- OriGene ORF clones in human for GATA3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GATA3
- GenScript: Next-day shipping of latest version cDNA ORF clones for GATA3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for GATA3
- GenScript Custom Assay Services for GATA3
- GenScript Custom overexpressing Cell Line Services for GATA3
- GenScript: Design CRISPR guide RNA sequences for GATA3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for GATA3
- Sino Biological Human cDNA Clone for GATA3
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Sino Biological Antibodies for GATA3
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for GATA3
- Novus Biologicals proteins and lysates for GATA3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for GATA3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GATA3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GATA3
- antibodies-online: Search results for 230 available GATA3 Antibodies ranked by validation data
- Compare Top GATA3 Antibodies
- Recommended
- 160 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 17 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 73 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 14 FACS Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 40 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Search results for 36 available GATA3 Elisa Kits ranked by validation data
- Compare Top GATA3 Elisa Kits
- antibodies-online: Search results for 9 available GATA3 Proteins ranked by validation data
- Compare Top GATA3 Proteins
- GeneTex GATA3 Antibody for GATA3
- Search GeneTex for Proteins for GATA3
- Santa Cruz Biotechnology (SCBT) Antibodies for GATA3
- Search Santa Cruz Biotechnology (SCBT) for GATA3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GATA3
- Custom Antibody ServicesProSci Antibodies for GATA3
- Search for GATA3 Proteins at ProSci
- Horizon Cell Lines for GATA3
- genomics-online: cdna clones - Search results for 121 available GATA3 gene related products
- Overview of 121 available GATA3 gene related products
- orf clones - Search results for 121 available GATA3 gene related products
- Overview of 121 available GATA3 gene related products
- genomics-online: gRNA clones - Search results for 121 available GATA3 gene related products
- Overview of 121 available GATA3 gene related products
- genomics-online: primer clones - Search results for 121 available GATA3 gene related products
- Overview of 121 available GATA3 gene related products
- genomics-online: shRNA clones - Search results for 121 available GATA3 gene related products
- Overview of 121 available GATA3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GATA3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GATA3
- GeneCopoeia miRNA 3'UTR Target clone products for GATA3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GATA3
Sources for GATA3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio