External Ids for GAST Gene
Previous HGNC Symbols for GAST Gene
Previous GeneCards Identifiers for GAST Gene
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]
GeneCards Summary for GAST Gene
GAST (Gastrin) is a Protein Coding gene. Diseases associated with GAST include Gastritis and Zollinger-Ellison Syndrome. Among its related pathways are Secretion of Hydrochloric Acid in Parietal Cells and RET signaling. Gene Ontology (GO) annotations related to this gene include hormone activity.
UniProtKB/Swiss-Prot Summary for GAST Gene
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.