Aliases for GASK1B Gene

Aliases for GASK1B Gene

  • Golgi Associated Kinase 1B 2 3 5
  • Expressed In Nerve And Epithelium During Development 2 3 4
  • ENED 2 3 4
  • Family With Sequence Similarity 198 Member B 2 3
  • Golgi-Associated Kinase 1B 3 4
  • Protein FAM198B 3 4
  • C4orf18 3 4
  • FAM198B 3 4
  • Family With Sequence Similarity 198, Member B 2
  • Chromosome 4 Open Reading Frame 18 2
  • DKFZp434L142 2
  • FLJ38155 2
  • GASK1B 5
  • AD021 3
  • AD036 3

External Ids for GASK1B Gene

Previous HGNC Symbols for GASK1B Gene

  • C4orf18
  • FAM198B

Summaries for GASK1B Gene

GeneCards Summary for GASK1B Gene

GASK1B (Golgi Associated Kinase 1B) is a Protein Coding gene. An important paralog of this gene is GASK1A.

Gene Wiki entry for GASK1B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GASK1B Gene

Genomics for GASK1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GASK1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J158163 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 252.7 +4.1 4063 11.9 MXD4 ZNF217 CTCF SAP130 KMT2B SMC3 GABPB1 RAD21 SIN3A TEAD3 FAM198B-AS1 GASK1B TMEM144 lnc-C4orf46-4 ENSG00000287822 HSALNG0038146 GRIA2
GH04J158229 Promoter/Enhancer 0.5 EPDnew dbSUPER 250.2 -55.4 -55360 0.1 GASK1B piR-45332-021 HSALNG0038157 TMEM144 RXFP1
GH04J158005 Enhancer 0.8 FANTOM5 Ensembl ENCODE 6 +167.3 167318 9.2 SPI1 POLR2A RFX1 HLF YY1 BMI1 WT1 FAM198B-AS1 TMEM144 GASK1B HSALNG0038139 piR-42806-010 LOC105377509 ENSG00000287226 GRIA2
GH04J158032 Enhancer 0.6 FANTOM5 ENCODE 6.2 +139.7 139722 1.9 JUND TFAP4 GASK1B FAM198B-AS1 piR-42806-010 LOC105377509 ENSG00000287226 GRIA2
GH04J157986 Enhancer 0.3 Ensembl 11.9 +184.8 184817 4.6 SPI1 FAM198B-AS1 GASK1B HSALNG0038139 ENSG00000250475 lnc-FAM198B-2 LOC105377509 ENSG00000287226 GRIA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GASK1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GASK1B

Genomic Locations for GASK1B Gene

Latest Assembly
chr4:158,124,474-158,173,318
(GRCh38/hg38)
Size:
48,845 bases
Orientation:
Minus strand

Previous Assembly
chr4:159,045,626-159,094,177
(GRCh37/hg19 by Entrez Gene)
Size:
48,552 bases
Orientation:
Minus strand

chr4:159,045,626-159,094,470
(GRCh37/hg19 by Ensembl)
Size:
48,845 bases
Orientation:
Minus strand

Genomic View for GASK1B Gene

Genes around GASK1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GASK1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GASK1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GASK1B Gene

Proteins for GASK1B Gene

  • Protein details for GASK1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWH4-GAK1B_HUMAN
    Recommended name:
    Golgi-associated kinase 1B
    Protein Accession:
    Q6UWH4
    Secondary Accessions:
    • Q498Z3
    • Q6IAF9
    • Q6ZMF2
    • Q86XL0

    Protein attributes for GASK1B Gene

    Size:
    519 amino acids
    Molecular mass:
    57552 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GASK1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GASK1B Gene

Post-translational modifications for GASK1B Gene

  • Glycosylation at Ser137, Ser149, and Asn289
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GASK1B Gene

Domains & Families for GASK1B Gene

Gene Families for GASK1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GASK1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GASK1B Gene

GenScript: Design optimal peptide antigens:
  • Expressed in nerve and epithelium during development (F198B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UWH4

UniProtKB/Swiss-Prot:

GAK1B_HUMAN :
  • Belongs to the GASK family.
Family:
  • Belongs to the GASK family.
genes like me logo Genes that share domains with GASK1B: view

Function for GASK1B Gene

Phenotypes From GWAS Catalog for GASK1B Gene

genes like me logo Genes that share phenotypes with GASK1B: view

Animal Models for research

  • Taconic Biosciences Mouse Models for GASK1B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GASK1B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GASK1B Gene

Localization for GASK1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GASK1B Gene

Golgi apparatus membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GASK1B gene
Compartment Confidence
golgi apparatus 4
mitochondrion 2
nucleus 2
extracellular 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GASK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GASK1B: view

Pathways & Interactions for GASK1B Gene

PathCards logo

SuperPathways for GASK1B Gene

No Data Available

Interacting Proteins for GASK1B Gene

Gene Ontology (GO) - Biological Process for GASK1B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GASK1B Gene

Drugs & Compounds for GASK1B Gene

No Compound Related Data Available

Transcripts for GASK1B Gene

mRNA/cDNA for GASK1B Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GASK1B

Alternative Splicing Database (ASD) splice patterns (SP) for GASK1B Gene

No ASD Table

Relevant External Links for GASK1B Gene

GeneLoc Exon Structure for
GASK1B

Expression for GASK1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GASK1B

SOURCE GeneReport for Unigene cluster for GASK1B Gene:

Hs.567498

Evidence on tissue expression from TISSUES for GASK1B Gene

  • Nervous system(4.8)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with GASK1B: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GASK1B Gene

Orthologs for GASK1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GASK1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM198B 30 31
  • 99.81 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fam198b 30 31
  • 81.23 (n)
OneToOne
Gask1b 17
Rat
(Rattus norvegicus)
Mammalia Fam198b 30
  • 80.74 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia FAM198B 31
  • 75 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM198B 31
  • 74 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FAM198B 31
  • 73 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM198B 31
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FAM198B 30 31
  • 65.68 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FAM198B 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam198b 30
  • 58.93 (n)
Zebrafish
(Danio rerio)
Actinopterygii fam198b 30 31
  • 55.51 (n)
OneToOne
Species where no ortholog for GASK1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GASK1B Gene

ENSEMBL:
Gene Tree for GASK1B (if available)
TreeFam:
Gene Tree for GASK1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GASK1B: view image

Paralogs for GASK1B Gene

Paralogs for GASK1B Gene

genes like me logo Genes that share paralogs with GASK1B: view

Variants for GASK1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GASK1B Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs17857283 - p.Gly432Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GASK1B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GASK1B Gene

Variant ID Type Subtype PubMed ID
esv3307783 CNV mobile element insertion 20981092
esv3388151 CNV insertion 20981092
nsv1021067 CNV gain 25217958

Variation tolerance for GASK1B Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GASK1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GASK1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GASK1B Gene

Disorders for GASK1B Gene

Additional Disease Information for GASK1B

Open Targets Platform
Open Targets Platform

No disorders were found for GASK1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GASK1B Gene

Publications for GASK1B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson JC … Wiemann S (EMBO reports 2000) 3 4
  4. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. (PMID: 29513927) Tomkins JE … Manzoni C (Proteomics 2018) 3
  5. FAM198B Is Associated with Prolonged Survival and Inhibits Metastasis in Lung Adenocarcinoma via Blockage of ERK-Mediated MMP-1 Expression. (PMID: 29217529) Hsu CY … Yu SL (Clinical cancer research : an official journal of the American Association for Cancer Research 2018) 3

Products for GASK1B Gene

Sources for GASK1B Gene