This gene encodes a long non-coding RNA (lncRNA) that may function as a tumor suppressor. Mutations in this gene have been identified in human papillary thyroid carcinoma (PTC) patients that abrogate the ability of encoded lncRNA to inhibit cancer cell growth. [provided by RefSeq, May 2017] See more...

Aliases for GAS8-AS1 Gene

Subcategory (RNA class) for GAS8-AS1 Gene

lncRNA

Number of RNA Genes sources:

2 / 17

Aliases for GAS8-AS1 Gene

  • GAS8 Antisense RNA 1 2 3 4 5
  • GAS8-AS1 2 5 165
  • C16orf3 3 4
  • Chromosome 16 Open Reading Frame 3 2
  • Uncharacterized Protein GAS8-AS1 4
  • Uncharacterized Protein C16orf3 3
  • GAS8 Antisense Gene Protein 1 4
  • HSALNG0113682 164

External Ids for GAS8-AS1 Gene

Previous HGNC Symbols for GAS8-AS1 Gene

  • C16orf3

Summaries for GAS8-AS1 Gene

Entrez Gene Summary for GAS8-AS1 Gene

  • This gene encodes a long non-coding RNA (lncRNA) that may function as a tumor suppressor. Mutations in this gene have been identified in human papillary thyroid carcinoma (PTC) patients that abrogate the ability of encoded lncRNA to inhibit cancer cell growth. [provided by RefSeq, May 2017]

GeneCards Summary for GAS8-AS1 Gene

GAS8-AS1 (GAS8 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with GAS8-AS1 include Differentiated Thyroid Carcinoma and Thyroid Gland Papillary Carcinoma.

Additional gene information for GAS8-AS1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GAS8-AS1 Gene

Genomics for GAS8-AS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GAS8-AS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAS8-AS1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for GAS8-AS1 Gene

Genomic Locations for GAS8-AS1 Gene
chr16:90,028,907-90,029,901
(GRCh38/hg38)
Size:
995 bases
Orientation:
Minus strand
chr16:90,095,316-90,096,309
(GRCh37/hg19)
Size:
994 bases
Orientation:
Minus strand

Genomic View for GAS8-AS1 Gene

Genes around GAS8-AS1 on UCSC Golden Path with GeneCards custom track
GAS8-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
GAS8-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS8-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS8-AS1 Gene

Proteins for GAS8-AS1 Gene

  • Protein details for GAS8-AS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95177-GAAS1_HUMAN
    Recommended name:
    Uncharacterized protein GAS8-AS1
    Protein Accession:
    O95177
    Secondary Accessions:
    • O95176
    • Q52LX9

    Protein attributes for GAS8-AS1 Gene

    Size:
    125 amino acids
    Molecular mass:
    12619 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GAS8-AS1 Gene

Post-translational modifications for GAS8-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for GAS8-AS1 Gene

Domains & Families for GAS8-AS1 Gene

Gene Families for GAS8-AS1 Gene

Protein Domains for GAS8-AS1 Gene

ProtoNet:
genes like me logo Genes that share domains with GAS8-AS1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GAS8-AS1 Gene

Function for GAS8-AS1 Gene

Phenotypes From GWAS Catalog for GAS8-AS1 Gene

Phenotypes for GAS8-AS1 Gene

genes like me logo Genes that share phenotypes with GAS8-AS1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAS8-AS1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAS8-AS1 Gene

Localization for GAS8-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS8-AS1 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GAS8-AS1 Gene

Pathways & Interactions for GAS8-AS1 Gene

PathCards logo

SuperPathways for GAS8-AS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GAS8-AS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for GAS8-AS1 Gene

Drugs & Compounds for GAS8-AS1 Gene

No Compound Related Data Available

Transcripts for GAS8-AS1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for GAS8-AS1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075E6C7_9606 lncRNA 994 2

HGNC: 1197,

RefSeq: NR_122031,

URS0000D5D290_9606 lncRNA 994 2

Ensembl: ENST00000408886 (view in UCSC) ,

LNCipedia: GAS8-AS1:1,

URS0000A7CB6C_9606 lncRNA 433 2

Ensembl: ENST00000623094 (view in UCSC) ,

LNCipedia: GAS8-AS1:2,

URS0000EBC5D5_9606 lncRNA 995 1

LncBook: HSALNT0289474,

URS00007CCDB6_9606 lncRNA 435 1

LNCipedia: GAS8-AS1:3,

GAS8-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for GAS8-AS1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAS8-AS1

Alternative Splicing Database (ASD) splice patterns (SP) for GAS8-AS1 Gene

No ASD Table

Relevant External Links for GAS8-AS1 Gene

GeneLoc Exon Structure for
GAS8-AS1

Expression for GAS8-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAS8-AS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GAS8-AS1

genes like me logo Genes that share expression patterns with GAS8-AS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS8-AS1 Gene

Orthologs for GAS8-AS1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GAS8-AS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C16orf3 31
  • 98 (a)
OneToOne
Species where no ortholog for GAS8-AS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for GAS8-AS1 Gene

ENSEMBL:
Gene Tree for GAS8-AS1 (if available)
TreeFam:
Gene Tree for GAS8-AS1 (if available)

Paralogs for GAS8-AS1 Gene

No data available for Paralogs for GAS8-AS1 Gene

Variants for GAS8-AS1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GAS8-AS1 Gene

GAAS1_HUMAN-O95177
There seem to be two alleles of this protein.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GAS8-AS1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs1555648296 Likely Benign: Autistic disorder of childhood onset 90,029,208(-) G/GGGCTGCCCCGCA NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
rs3785183 - p.Val72Ile

Additional dbSNP identifiers (rs#s) for GAS8-AS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GAS8-AS1 Gene

Variant ID Type Subtype PubMed ID
dgv3067n100 CNV gain 25217958
esv2762221 CNV gain+loss 21179565
esv3639603 CNV gain 21293372
esv3639606 CNV gain 21293372
nsv1062080 CNV loss 25217958
nsv1064351 CNV gain+loss 25217958
nsv1067164 CNV gain+loss 25217958
nsv428331 CNV gain+loss 18775914
nsv457626 CNV loss 19166990
nsv471119 CNV loss 18288195
nsv471120 CNV gain 18288195
nsv482951 CNV loss 15286789
nsv573810 CNV loss 21841781
nsv573841 CNV loss 21841781
nsv573842 CNV loss 21841781
nsv952080 CNV deletion 24416366

Variation tolerance for GAS8-AS1 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.62; 78.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAS8-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAS8-AS1

Disorders for GAS8-AS1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GAS8-AS1 Gene - From: LncRNADisease and Orphanet

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
thyroid gland papillary carcinoma
  • papillary carcinoma of the thyroid gland
thyroid cancer, nonmedullary, 1
  • nmtc1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with GAS8-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAS8-AS1 Gene

Publications for GAS8-AS1 Gene

  1. Characterization and screening for mutations of the growth arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer. (PMID: 9790751) Whitmore SA … Callen DF (Genomics 1998) 2 3 4
  2. Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients. (PMID: 28781594) Zhang D … Chen Z (International journal of endocrinology 2017) 2 3
  3. Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4 as novel papillary thyroid carcinoma driver alternations. (PMID: 26941397) Pan W … Lin D (Human molecular genetics 2016) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. LncRNA GAS8-AS inhibits colorectal cancer (CRC) cell proliferation by downregulating lncRNA AFAP1-AS1. (PMID: 31132513) Zhao Y … Xu F (Gene 2019) 3

Products for GAS8-AS1 Gene

Sources for GAS8-AS1 Gene