Aliases for GAS8 Gene
Aliases for GAS8 Gene
External Ids for GAS8 Gene
- HGNC: 4166
- Entrez Gene: 2622
- Ensembl: ENSG00000141013
- OMIM: 605178
- UniProtKB: O95995
Previous HGNC Symbols for GAS8 Gene
- GAS11
Previous GeneCards Identifiers for GAS8 Gene
- GC16P091073
- GC16P089787
- GC16P089828
- GC16P089831
- GC16P088613
- GC16P090089
- GC16P075780
Summaries for GAS8 Gene
-
This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
GeneCards Summary for GAS8 Gene
GAS8 (Growth Arrest Specific 8) is a Protein Coding gene. Diseases associated with GAS8 include Ciliary Dyskinesia, Primary, 33. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include Rab GTPase binding.
UniProtKB/Swiss-Prot for GAS8 Gene
-
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning (PubMed:26387594, PubMed:27120127, PubMed:27472056). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity).
Additional gene information for GAS8 Gene
- Monarch Initiative
- Search for GAS8 at DataMed
- Search for GAS8 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAS8 Gene
Genomics for GAS8 Gene
GeneHancer (GH) Regulatory Elements for GAS8 Gene
Promoters and enhancers for GAS8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GAS8 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GAS8 gene promoter:
-
- SREBP-1c
- SREBP-1b
- SREBP-1a
- Spz1
- GATA-1
- HOXA3
- GATA-2
- Sp1
- NF-kappaB
- NF-kappaB1
Regulatory Element Products
Genomic Locations for GAS8 Gene
Genomic Locations for GAS8 Gene
- chr16:90,019,629-90,044,975
- (GRCh38/hg38)
- Size:
- 25,347 bases
- Orientation:
- Plus strand
- chr16:90,086,037-90,111,383
- (GRCh37/hg19)
- Size:
- 25,347 bases
- Orientation:
- Plus strand
Genomic View for GAS8 Gene
Genes around GAS8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.3 by Entrez Gene
- 16q24.3 by HGNC
- 16q24.3 by Ensembl
GAS8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GAS8 Gene
Proteins for GAS8 Gene
-
Protein details for GAS8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95995-DRC4_HUMAN
- Recommended name:
- Dynein regulatory complex subunit 4
- Protein Accession:
- O95995
- B2RCT1
- B7Z4U1
- G3V1L5
- Q2M234
Protein attributes for GAS8 Gene
- Size:
- 478 amino acids
- Molecular mass:
- 56356 Da
- Quaternary structure:
-
- Component of the nexin-dynein regulatory complex (N-DRC). Interacts with microtubules (By similarity). Interacts with SMO (PubMed:21659505). Interacts (via coiled-coil domains) with RAB3B (in GTP-bound form) (By similarity).
Protein Expression for GAS8 Gene
Post-translational modifications for GAS8 Gene
Other Protein References for GAS8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GAS8
- Invitrogen Antibodies for GAS8 (AFLGC-GAS8)
- GeneTex GAS8 Antibody for GAS8
-
Boster Bio Antibodies for GAS8
-
Santa Cruz Biotechnology (SCBT) Antibodies for GAS8
Protein Products
-
OriGene Purified Proteins for GAS8
- Search Origene for MassSpec and Protein Over-expression Lysates for GAS8
- Origene Custom Protein Services for GAS8
- antibodies-online: Search results for 6 available GAS8 Proteins ranked by validation data
- Compare Top GAS8 Proteins
-
Quality Products:
- Search GeneTex for Proteins for GAS8
Assay Products
- antibodies-online: Search results for available GAS8 related products ranked by validation data
No data available for DME Specific Peptides for GAS8 Gene
Domains & Families for GAS8 Gene
Gene Families for GAS8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for GAS8 Gene
Graphical View of Domain Structure for InterPro Entry
O95995- Family:
-
- Belongs to the DRC4 family.
Function for GAS8 Gene
Molecular function for GAS8 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning (PubMed:26387594, PubMed:27120127, PubMed:27472056). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity).
Phenotypes From GWAS Catalog for GAS8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005515 | protein binding | IPI | 21659505 |
| GO:0008017 | microtubule binding | IEA,ISS | -- |
| GO:0017137 | Rab GTPase binding | IEA,IBA | -- |
Phenotypes for GAS8 Gene
- MGI mutant phenotypes for GAS8:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for GAS8:
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for GAS8
-
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-
OriGene CRISPR knockouts for GAS8
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- Overview of 128 available GAS8 gene related products
- Applied Biological Materials CRISPR for GAS8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GAS8
- GenScript: Design CRISPR guide RNA sequences for GAS8
miRNA for GAS8 Gene
- miRTarBase miRNAs that target GAS8
miRNA Products
Inhibitory RNA Products
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- Overview of 128 available GAS8 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GAS8
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- Applied Biological Materials Clones for GAS8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GAS8
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GAS8 Gene
Localization for GAS8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GAS8 Gene
- Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus. Cell projection, cilium. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Associates with microtubules (PubMed:10969087). Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa (By similarity). {ECO:0000250 UniProtKB:Q60779, ECO:0000269 PubMed:10969087}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| golgi apparatus | 4 |
| nucleus | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
- Cytosol (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IBA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005874 | microtubule | IEA,IDA | 10969087 |
| GO:0005929 | cilium | IEA,IDA | 16643277 |
Pathways & Interactions for GAS8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 2 | GPCR Pathway |
.73
.62
|
.55
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
| 5 | CREB Pathway |
.68
.68
|
|
Pathways by source for GAS8 Gene
4 Reactome pathways for GAS8 Gene
Interacting Proteins for GAS8 Gene
Selected Interacting proteins:
O95995-DRC4_HUMAN
ENSP00000268699
for GAS8 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for GAS8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003351 | epithelial cilium movement | IEA | -- |
| GO:0007368 | determination of left/right symmetry | IEA | -- |
| GO:0007420 | brain development | IEA | -- |
| GO:0008285 | negative regulation of cell proliferation | TAS | 9790751 |
| GO:0030317 | flagellated sperm motility | ISS,IEA | -- |
No data available for SIGNOR curated interactions for GAS8 Gene
Transcripts for GAS8 Gene
mRNA/cDNA for GAS8 Gene
- (14) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (97) Selected AceView cDNA sequences:
- (20) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000563980 546 bps (uc059yvr.1)
- ENST00000565957 549 bps (uc059yvs.1)
- ENST00000536122 1687 bps (uc010vps.2)
- ENST00000568705 659 bps (uc059yvu.1)
- ENST00000568664 341 bps (uc059yvv.1)
Unigene Clusters for GAS8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GAS8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GAS8
- genomics-online: gRNA clones - Search results for 128 available GAS8 gene related products
- Overview of 128 available GAS8 gene related products
- Applied Biological Materials CRISPR for GAS8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GAS8
- GenScript: Design CRISPR guide RNA sequences for GAS8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GAS8
- Browse OriGene Inhibitory RNA Products For GAS8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAS8
- genomics-online: shRNA clones - Search results for 128 available GAS8 gene related products
- Overview of 128 available GAS8 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GAS8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GAS8
- Applied Biological Materials Clones for GAS8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for GAS8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
This gene is overexpressed in Stomach (33.3) and Plasma (22.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GAS8 Gene
NURSA nuclear receptor signaling pathways regulating expression of GAS8 Gene:
GAS8SOURCE GeneReport for Unigene cluster for GAS8 Gene:
Hs.431792mRNA Expression by UniProt/SwissProt for GAS8 Gene:
O95995-DRC4_HUMAN
Tissue specificity:
Expressed in respiratory epithelial cells (at protein level) (PubMed:26387594). Expressed in the heart, skeletal muscle, pancreas, liver, brain, trachea and lung. Weakly or not expressed in placenta and kidney (PubMed:9790751).
Evidence on tissue expression from TISSUES for GAS8 Gene
- Nervous system(4.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS8 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cranial nerve
- ear
- epiglottis
- eye
- head
- larynx
- meninges
- middle ear
- mouth
- neck
- nose
- olfactory bulb
- outer ear
- pharynx
- sinus
- skull
Thorax:
- bronchus
- lung
- trachea
Abdomen:
- spleen
Pelvis:
- ovary
- testicle
General:
- blood
- blood vessel
- peripheral nervous system
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for GAS8
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for GAS8 Gene
Orthologs for GAS8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GAS8 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GAS8 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GAS8 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gas8 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gas8 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GAS8 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GAS8 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GAS8 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GAS8 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gas8 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gas8 34 33 |
|
OneToOne | |
| -- 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005850 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Gas8 34 33 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4120 34 |
|
OneToOne |
- Species where no ortholog for GAS8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for GAS8 Gene
- ENSEMBL:
- Gene Tree for GAS8 (if available)
- TreeFam:
- Gene Tree for GAS8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GAS8: view image
Paralogs for GAS8 Gene
(1) SIMAP similar genes for GAS8 Gene using alignment to 7 proteins:
- GAS8_HUMAN
- G3V1L5_HUMAN
- H3BME0_HUMAN
- H3BNL3_HUMAN
- H3BP65_HUMAN
- H3BQT7_HUMAN
- H3BUA7_HUMAN
No data available for Paralogs for GAS8 Gene
Variants for GAS8 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs116113385 | benign, Ciliary dyskinesia, primary, 33 | 90,032,905(+) | T/A | 5_prime_UTR_variant, coding_sequence_variant, missense_variant | |
| rs117053233 | benign, Ciliary dyskinesia, primary, 33 | 90,037,308(+) | G/A | coding_sequence_variant, missense_variant | |
| rs141125763 | likely-benign, Ciliary dyskinesia, primary, 33 | 90,037,283(+) | G/C | coding_sequence_variant, missense_variant | |
| rs143772256 | likely-benign, Ciliary dyskinesia, primary, 33 | 90,040,498(+) | C/G/T | coding_sequence_variant, missense_variant | |
| rs146066553 | uncertain-significance, Ciliary dyskinesia, primary, 33 | 90,027,663(+) | A/G | 5_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3067n100 | CNV | gain | 25217958 |
| esv2676928 | CNV | deletion | 23128226 |
| esv2762221 | CNV | gain+loss | 21179565 |
| esv3553923 | CNV | deletion | 23714750 |
| esv3639603 | CNV | gain | 21293372 |
| esv3639606 | CNV | gain | 21293372 |
| esv3639607 | CNV | gain | 21293372 |
| esv3639608 | CNV | loss | 21293372 |
| nsv1062080 | CNV | loss | 25217958 |
| nsv1064351 | CNV | gain+loss | 25217958 |
| nsv1066499 | CNV | loss | 25217958 |
| nsv1067164 | CNV | gain+loss | 25217958 |
| nsv1070787 | CNV | deletion | 25765185 |
| nsv1118586 | CNV | duplication | 24896259 |
| nsv1933 | CNV | insertion | 18451855 |
| nsv428331 | CNV | gain+loss | 18775914 |
| nsv457626 | CNV | loss | 19166990 |
| nsv471119 | CNV | loss | 18288195 |
| nsv471120 | CNV | gain | 18288195 |
| nsv472797 | CNV | novel sequence insertion | 20440878 |
| nsv482951 | CNV | loss | 15286789 |
| nsv509641 | CNV | insertion | 20534489 |
| nsv573799 | CNV | gain | 21841781 |
| nsv573810 | CNV | loss | 21841781 |
| nsv573841 | CNV | loss | 21841781 |
| nsv573842 | CNV | loss | 21841781 |
| nsv952080 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.08;
68.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GAS8 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS8 Gene
Disorders for GAS8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ciliary dyskinesia, primary, 33 |
|
Search GAS8 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
DRC4_HUMAN- Ciliary dyskinesia, primary, 33 (CILD33) [MIM:616726]: A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD33 inheritance is autosomal recessive. {ECO:0000269 PubMed:26387594, ECO:0000269 PubMed:27120127, ECO:0000269 PubMed:27472056}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for GAS8
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for GAS8 Gene
Publications for GAS8 Gene
- Characterization and screening for mutations of the growth arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer. (PMID: 9790751) Whitmore SA … Callen DF (Genomics 1998) 2 3 4 22 58
- T lymphocyte-triggering factor of african trypanosomes is associated with the flagellar fraction of the cytoskeleton and represents a new family of proteins that are present in several divergent eukaryotes. (PMID: 10969087) Hill KL … Donelson JE (The Journal of biological chemistry 2000) 3 4 22 58
- Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease. (PMID: 27472056) Lewis WR … Berbari NF (PLoS genetics 2016) 3 4 58
- Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization. (PMID: 27120127) Jeanson L … Legendre M (Human mutation 2016) 3 4 58
- Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex. (PMID: 26387594) Olbrich H … Omran H (American journal of human genetics 2015) 3 4 58
Products for GAS8 Gene
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- GenScript: Design CRISPR guide RNA sequences for GAS8
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- Sino Biological Human cDNA Clone for GAS8
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GAS8
- Novus Biologicals proteins and lysates for GAS8
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for GAS8 (AFLGC-GAS8)
- Cyagen custom Knockout/knockin (KOKI) mouse models for GAS8
- antibodies-online: Search results for 31 available GAS8 Antibodies ranked by validation data
- Compare Top GAS8 Antibodies
- antibodies-online: Search results for available GAS8 related products ranked by validation data
- antibodies-online: Search results for 6 available GAS8 Proteins ranked by validation data
- Compare Top GAS8 Proteins
- Quality Products:
- GeneTex GAS8 Antibody for GAS8
- Search GeneTex for Proteins for GAS8
- Santa Cruz Biotechnology (SCBT) Antibodies for GAS8
- Search Santa Cruz Biotechnology (SCBT) for GAS8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GAS8
- Horizon Cell Lines for GAS8
- genomics-online: cdna clones - Search results for 128 available GAS8 gene related products
- Overview of 128 available GAS8 gene related products
- orf clones - Search results for 128 available GAS8 gene related products
- Overview of 128 available GAS8 gene related products
- genomics-online: gRNA clones - Search results for 128 available GAS8 gene related products
- Overview of 128 available GAS8 gene related products
- genomics-online: primer clones - Search results for 128 available GAS8 gene related products
- Overview of 128 available GAS8 gene related products
- genomics-online: shRNA clones - Search results for 128 available GAS8 gene related products
- Overview of 128 available GAS8 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GAS8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GAS8
- GeneCopoeia miRNA 3'UTR Target clone products for GAS8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAS8
- Boster Bio Antibodies for GAS8
- Browse Boster Bio ELISA Kits
Sources for GAS8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt