This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, syste... See more...

Aliases for GAS6 Gene

Aliases for GAS6 Gene

  • Growth Arrest Specific 6 2 3 5
  • AXL Receptor Tyrosine Kinase Ligand 2 3 4
  • Growth Arrest-Specific Protein 6 3 4
  • AXL Stimulatory Factor 2 3
  • AXLLG 3 4
  • AXSF 2 3
  • DKFZp666G247 2
  • FLJ34709 2
  • GAS-6 4
  • GAS6 5

External Ids for GAS6 Gene

Previous HGNC Symbols for GAS6 Gene

  • AXLLG

Previous GeneCards Identifiers for GAS6 Gene

  • GC13U990018
  • GC13P113563
  • GC13P112446
  • GC13P113546
  • GC13M114523
  • GC13P094864

Summaries for GAS6 Gene

Entrez Gene Summary for GAS6 Gene

  • This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

CIViC Summary for GAS6 Gene

GeneCards Summary for GAS6 Gene

GAS6 (Growth Arrest Specific 6) is a Protein Coding gene. Diseases associated with GAS6 include Sticky Platelet Syndrome and Mesangial Proliferative Glomerulonephritis. Among its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include calcium ion binding and voltage-gated calcium channel activity. An important paralog of this gene is MEGF6.

UniProtKB/Swiss-Prot Summary for GAS6 Gene

  • Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
  • (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).

Gene Wiki entry for GAS6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GAS6 Gene

Genomics for GAS6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GAS6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAS6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GAS6

Top Transcription factor binding sites by QIAGEN in the GAS6 gene promoter:
  • Bach2
  • FOXF2
  • HOXA9
  • HSF2
  • Olf-1
  • p53

Genomic Locations for GAS6 Gene

Genomic Locations for GAS6 Gene
chr13:113,820,549-113,864,076
(GRCh38/hg38)
Size:
43,528 bases
Orientation:
Minus strand
chr13:114,523,522-114,567,046
(GRCh37/hg19)
Size:
43,525 bases
Orientation:
Minus strand

Genomic View for GAS6 Gene

Genes around GAS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAS6 Gene

Proteins for GAS6 Gene

  • Protein details for GAS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14393-GAS6_HUMAN
    Recommended name:
    Growth arrest-specific protein 6
    Protein Accession:
    Q14393
    Secondary Accessions:
    • B3KRQ7
    • B3KVL4
    • E9PBL7
    • Q6IMN1
    • Q7Z7N3

    Protein attributes for GAS6 Gene

    Size:
    678 amino acids
    Molecular mass:
    74925 Da
    Quaternary structure:
    • Heterodimer and heterotetramer with AXL.

    Three dimensional structures from OCA and Proteopedia for GAS6 Gene

    Alternative splice isoforms for GAS6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GAS6 Gene

Post-translational modifications for GAS6 Gene

  • [Isoform 2]: Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.
  • Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
  • Glycosylation at Asn420
  • Modification sites at PhosphoSitePlus

Other Protein References for GAS6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAS6 Gene

Domains & Families for GAS6 Gene

Gene Families for GAS6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for GAS6 Gene

InterPro:
Blocks:
  • EGF-like calcium-binding
  • Laminin G
  • Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
  • Coagulation factor GLA domain signature
ProtoNet:

Suggested Antigen Peptide Sequences for GAS6 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ16711 fis, clone UTERU2023045, highly similar to Growth-arrest-specific protein 6 (B3KVL4_HUMAN)
  • AXL receptor tyrosine kinase ligand (GAS6_HUMAN)
genes like me logo Genes that share domains with GAS6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GAS6 Gene

Function for GAS6 Gene

Molecular function for GAS6 Gene

UniProtKB/Swiss-Prot Function:
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).
GENATLAS Biochemistry:
growth arrest specific gene 6,with homology to PROS1,ligand for TYRO3/AXL family of receptor tyrosine kinase

Phenotypes From GWAS Catalog for GAS6 Gene

Gene Ontology (GO) - Molecular Function for GAS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IDA 21501828
GO:0005102 signaling receptor binding IPI 7854420
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 18760998
GO:0030296 protein tyrosine kinase activator activity IDA 20103767
genes like me logo Genes that share ontologies with GAS6: view
genes like me logo Genes that share phenotypes with GAS6: view

Animal Models for GAS6 Gene

MGI Knock Outs for GAS6:
  • Gas6 Gas6<tm1Hiar>
  • Gas6 Gas6<tm1.1(KOMP)Vlcg>
  • Gas6 Gas6<tm1Pec>

Animal Model Products

  • Taconic Biosciences Mouse Models for GAS6

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAS6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GAS6 Gene

Localization for GAS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAS6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS6 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 3
cytoskeleton 3
cytosol 3
mitochondrion 2
nucleus 2
endosome 2
lysosome 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GAS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IDA 8336730
GO:0005623 cell IEA --
GO:0005737 cytoplasm IDA 18395422
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with GAS6: view

Pathways & Interactions for GAS6 Gene

PathCards logo

SuperPathways for GAS6 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
3 ERK Signaling
.61
.61
.58
.51
.49
4 Gamma carboxylation, hypusine formation and arylsulfatase activation
5 Nanog in Mammalian ESC Pluripotency
.62
.62
.59
.48
genes like me logo Genes that share pathways with GAS6: view

Pathways by source for GAS6 Gene

54 Qiagen pathways for GAS6 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
1 Cell Signaling Technology pathway for GAS6 Gene

SIGNOR curated interactions for GAS6 Gene

Activates:

Gene Ontology (GO) - Biological Process for GAS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0001934 positive regulation of protein phosphorylation IEA,ISS --
GO:0001961 positive regulation of cytokine-mediated signaling pathway IMP 18840707
GO:0002576 platelet degranulation TAS --
GO:0003104 positive regulation of glomerular filtration IEA,ISS --
genes like me logo Genes that share ontologies with GAS6: view

Drugs & Compounds for GAS6 Gene

(6) Drugs for GAS6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556

(3) Additional Compounds for GAS6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GAS6: view

Transcripts for GAS6 Gene

mRNA/cDNA for GAS6 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAS6

Alternative Splicing Database (ASD) splice patterns (SP) for GAS6 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: -
SP3:
SP4: - -
SP5: - -
SP6: - - - - -
SP7:
SP8:
SP9: -
SP10:

Relevant External Links for GAS6 Gene

GeneLoc Exon Structure for
GAS6

Expression for GAS6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GAS6 Gene

This gene is overexpressed in Artery - Aorta (x6.5).

Protein differential expression in normal tissues from HIPED for GAS6 Gene

This gene is overexpressed in Amniocyte (24.4), Breast (14.6), Bone marrow mesenchymal stem cell (9.5), Urine (7.9), and Bone marrow stromal cell (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GAS6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GAS6

SOURCE GeneReport for Unigene cluster for GAS6 Gene:

Hs.646346

mRNA Expression by UniProt/SwissProt for GAS6 Gene:

Q14393-GAS6_HUMAN
Tissue specificity: Plasma. Isoform 1 and isoform 2 are widely expressed, isoform 1 being expressed at higher levels than isoform 2 in most tissues. Isoform 2 is the predominant form in spleen.

Evidence on tissue expression from TISSUES for GAS6 Gene

  • Lung(4.9)
  • Kidney(4.6)
  • Spleen(4.6)
  • Nervous system(4.4)
  • Bone(3.5)
  • Skin(3.3)
  • Heart(3.2)
  • Blood(3.1)
  • Muscle(3.1)
  • Intestine(2.9)
  • Lymph node(2.8)
  • Eye(2.7)
  • Liver(2.6)
  • Thyroid gland(2.3)
  • Pancreas(2.3)
  • Bone marrow(2.2)
  • Stomach(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with GAS6: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS6 Gene

Orthologs for GAS6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAS6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GAS6 30 31
  • 92.07 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GAS6 30 31
  • 82.74 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gas6 30
  • 80.93 (n)
Mouse
(Mus musculus)
Mammalia Gas6 30 17 31
  • 80.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GAS6 30 31
  • 79.53 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GAS6 31
  • 71 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GAS6 31
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GAS6 30 31
  • 66.84 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GAS6 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gas6 30
  • 63.67 (n)
Str.18141 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68463 30
Zebrafish
(Danio rerio)
Actinopterygii gas6 30 31
  • 60.05 (n)
OneToOne
wufj34a12 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
Species where no ortholog for GAS6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GAS6 Gene

ENSEMBL:
Gene Tree for GAS6 (if available)
TreeFam:
Gene Tree for GAS6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GAS6: view image

Paralogs for GAS6 Gene

Paralogs for GAS6 Gene

(9) SIMAP similar genes for GAS6 Gene using alignment to 2 proteins:

  • GAS6_HUMAN
  • J3KP07_HUMAN
genes like me logo Genes that share paralogs with GAS6: view

Variants for GAS6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GAS6 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
713017 Likely Benign: not provided 113,821,021(-) G/A INTRON_VARIANT
713018 Benign: not provided 113,835,542(-) G/A MISSENSE_VARIANT
722726 Benign: not provided 113,832,760(-) G/A INTRON_VARIANT
731365 Benign: not provided 113,822,049(-) G/A SYNONYMOUS_VARIANT
741682 Likely Benign: not provided 113,834,569(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for GAS6 Gene

Structural Variations from Database of Genomic Variants (DGV) for GAS6 Gene

Variant ID Type Subtype PubMed ID
dgv1046n106 CNV duplication 24896259
dgv1134e59 CNV duplication 20981092
dgv1135e59 CNV duplication 20981092
dgv257e201 CNV deletion 23290073
dgv258e201 CNV deletion 23290073
dgv3450n54 CNV gain 21841781
dgv3451n54 CNV loss 21841781
esv1157105 CNV insertion 17803354
esv1258186 CNV insertion 17803354
esv1344439 CNV insertion 17803354
esv1443107 CNV insertion 17803354
esv1444149 CNV deletion 17803354
esv1993584 CNV deletion 18987734
esv24756 CNV gain+loss 19812545
esv2493664 CNV deletion 19546169
esv2677402 CNV deletion 23128226
esv27370 CNV loss 19812545
esv2748392 CNV deletion 23290073
esv2748393 CNV deletion 23290073
esv2748394 CNV deletion 23290073
esv2748395 CNV deletion 23290073
esv2748396 CNV deletion 23290073
esv2748398 CNV deletion 23290073
esv2748399 CNV deletion 23290073
esv2748401 CNV deletion 23290073
esv2748403 CNV deletion 23290073
esv2748404 CNV deletion 23290073
esv2748406 CNV deletion 23290073
esv2748409 CNV deletion 23290073
esv2748410 CNV deletion 23290073
esv2748411 CNV deletion 23290073
esv2748412 CNV deletion 23290073
esv2748413 CNV deletion 23290073
esv2748414 CNV deletion 23290073
esv2748415 CNV deletion 23290073
esv2748416 CNV deletion 23290073
esv2748417 CNV deletion 23290073
esv3395766 CNV duplication 20981092
esv3410329 CNV duplication 20981092
esv3551172 CNV deletion 23714750
esv3551174 CNV deletion 23714750
esv3582860 CNV gain 25503493
esv3633615 CNV gain 21293372
esv3633621 CNV loss 21293372
esv3633622 CNV gain 21293372
esv3633624 CNV loss 21293372
esv3633625 CNV gain 21293372
esv3633626 CNV gain 21293372
nsv1043348 CNV gain 25217958
nsv1070623 CNV deletion 25765185
nsv1075857 CNV duplication 25765185
nsv1111098 CNV tandem duplication 24896259
nsv1118277 CNV deletion 24896259
nsv1122874 CNV deletion 24896259
nsv1126356 CNV deletion 24896259
nsv1127369 CNV deletion 24896259
nsv1129173 CNV insertion 24896259
nsv1135806 CNV deletion 24896259
nsv1142162 CNV tandem duplication 24896259
nsv1145700 CNV deletion 24896259
nsv1148131 CNV insertion 26484159
nsv1149173 CNV duplication 26484159
nsv511027 OTHER inversion 20534489
nsv563387 CNV loss 21841781
nsv563388 CNV loss 21841781
nsv563390 CNV loss 21841781
nsv563391 CNV loss 21841781
nsv563392 CNV loss 21841781
nsv820519 CNV duplication 20802225
nsv826836 CNV loss 20364138
nsv826837 CNV loss 20364138
nsv832727 CNV loss 17160897
nsv951933 CNV deletion 24416366
nsv957449 CNV deletion 24416366
nsv957485 CNV deletion 24416366

Variation tolerance for GAS6 Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GAS6 Gene

Human Gene Mutation Database (HGMD)
GAS6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAS6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAS6 Gene

Disorders for GAS6 Gene

MalaCards: The human disease database

(9) MalaCards diseases for GAS6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sticky platelet syndrome
mesangial proliferative glomerulonephritis
  • glomerulonephritis - mesangial proliferative
lupus erythematosus
  • systemic lupus erythematosus
demyelinating polyneuropathy
  • peripheral demyelinating neuropathy
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards
Search GAS6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GAS6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GAS6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAS6 Gene

Publications for GAS6 Gene

  1. Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke. (PMID: 15108283) Muñoz X … Sala N (Human mutation 2004) 3 4 23 41
  2. The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. (PMID: 8336730) Manfioletti G … Schneider C (Molecular and cellular biology 1993) 2 3 4 23
  3. Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome. (PMID: 19369636) Jiang L … Zhang W (American journal of clinical pathology 2009) 3 23 41
  4. Association of specific haplotypes of GAS6 gene with stroke. (PMID: 17721624) Muñoz X … Sala N (Thrombosis and haemostasis 2007) 3 23 41
  5. Structural basis for Gas6-Axl signalling. (PMID: 16362042) Sasaki T … Hohenester E (The EMBO journal 2006) 3 4 23

Products for GAS6 Gene

Sources for GAS6 Gene