GAS5 Gene (RNA Gene)

Growth Arrest Specific 5

GC01M173947
GIFtS:
23
This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glu... See more...

Aliases for GAS5 Gene

Subcategory (RNA class) for GAS5 Gene

lncRNA

Number of RNA Genes sources:

4 / 17

Aliases for GAS5 Gene

  • Growth Arrest Specific 5 2 3 5
  • GAS5 2 5 165
  • Small Nucleolar RNA Host Gene (Non-Protein Coding) 2 2 3
  • Growth Arrest Specific 5 (Non-Protein Coding) 2 3
  • NCRNA00030 2 3
  • SNHG2 2 3
  • Growth Arrest Specific Transcript 5 3
  • Non-Protein Coding RNA 30 2
  • NONHSAG003504.2 91
  • HSALNG0008545 164

External Ids for GAS5 Gene

Previous GeneCards Identifiers for GAS5 Gene

  • GC01U990348
  • GC01M172108
  • GC01M172117
  • GC01M172125
  • GC01M172133
  • GC01M172142
  • GC01M172146
  • GC01M172157
  • GC01M172170
  • GC01M173843
  • GC01M173850
  • GC01M173855
  • GC01M173864
  • GC01M173874
  • GC01M173883
  • GC01M173892
  • GC01M173907
  • GC01M173919
  • GC01M173937
  • GC01M173961
  • GC01M174061
  • GC01M174052
  • GC01M174067
  • GC01M174119
  • GC01M173977
  • GC01M173985
  • GC01M173989
  • GC01M173997
  • GC01M174007
  • GC01M174021
  • GC01M174034
  • GC01M174047

Summaries for GAS5 Gene

Entrez Gene Summary for GAS5 Gene

  • This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]

GeneCards Summary for GAS5 Gene

GAS5 (Growth Arrest Specific 5) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with GAS5 include Malignant Pleural Mesothelioma and Autoimmune Disease.

Gene Wiki entry for GAS5 Gene

Rfam classification for GAS5 Gene

  • Small nucleolar RNA SNORD77
  • Small nucleolar RNA SNORD47
  • Small nucleolar RNA SNORD44
  • Small nucleolar RNA snR60/Z15/Z230/Z193/J17
  • Small nucleolar RNA SNORD24
  • Small nucleolar RNA SNORD79
  • Small nucleolar RNA SNORD81
  • Small nucleolar RNA SNORD74
  • Small nucleolar RNA SNORD75

Additional gene information for GAS5 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for GAS5 Gene

Genomics for GAS5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GAS5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GAS5 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the GAS5 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • CREB
  • deltaCREB
  • Ik-2
  • IRF-1
  • LCR-F1
  • Pax-4a

Genomic Locations for GAS5 Gene

Genomic Locations for GAS5 Gene
chr1:173,851,285-173,869,006
(GRCh38/hg38)
Size:
17,722 bases
Orientation:
Minus strand
chr1:173,833,038-173,838,020
(GRCh37/hg19)
Size:
4,983 bases
Orientation:
Minus strand

Genomic View for GAS5 Gene

Genes around GAS5 on UCSC Golden Path with GeneCards custom track
GAS5 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
GAS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAS5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GAS5 Gene

Proteins for GAS5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for GAS5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for GAS5 Gene

Domains & Families for GAS5 Gene

Gene Families for GAS5 Gene

HGNC:
genes like me logo Genes that share domains with GAS5: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GAS5 Gene

Function for GAS5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for GAS5 Gene

Animal Model Products

CRISPR Products

miRNA for GAS5 Gene

miRTarBase miRNAs that target GAS5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GAS5 Gene

Localization for GAS5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GAS5 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GAS5 Gene

Pathways & Interactions for GAS5 Gene

PathCards logo

SuperPathways for GAS5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GAS5 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for GAS5 Gene

Drugs & Compounds for GAS5 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for GAS5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

Non-coding RNA (ncRNA) Transcripts from RNAcentral for GAS5 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00009C227F_9606 lncRNA 1007 4

Ensembl: ENST00000451607 (view in UCSC) ,

LncBook: HSALNT0017748,

LNCipedia: GAS5:24,

NONCODE: NONHSAT152562.1,

URS00008C2BF5_9606 lncRNA 723 4

Ensembl: ENST00000430245 (view in UCSC) ,

LncBook: HSALNT0017700,

LNCipedia: GAS5:1,

NONCODE: NONHSAT007668.2,

URS00008C0D76_9606 lncRNA 688 4

Ensembl: ENST00000454068 (view in UCSC) ,

LncBook: HSALNT0017732,

LNCipedia: GAS5:22,

NONCODE: NONHSAT007681.2,

URS00009B629F_9606 lncRNA 632 4

Ensembl: ENST00000450589 (view in UCSC) ,

LncBook: HSALNT0017702,

LNCipedia: GAS5:15,

NONCODE: NONHSAT007663.2,

URS00008C15F6_9606 lncRNA 542 4

Ensembl: ENST00000449289 (view in UCSC) ,

LncBook: HSALNT0017690,

LNCipedia: GAS5:53, GAS5:6,

NONCODE: NONHSAT007662.2,

GAS5 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for GAS5 Gene

16 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAS5 Gene

No ASD Table

Relevant External Links for GAS5 Gene

GeneLoc Exon Structure for
GAS5

Expression for GAS5 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GAS5 Gene

mRNA expression in normal human tissues for GAS5 Gene
mRNA expression by GTEx for GAS5 Gene

mRNA differential expression in normal tissues according to GTEx for GAS5 Gene

This gene is overexpressed in Pancreas (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GAS5

SOURCE GeneReport for Unigene cluster for GAS5 Gene:

Hs.531856

Evidence on tissue expression from TISSUES for GAS5 Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with GAS5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAS5 Gene

Orthologs for GAS5 Gene

Evolution for GAS5 Gene

ENSEMBL:
Gene Tree for GAS5 (if available)
TreeFam:
Gene Tree for GAS5 (if available)

No data available for Orthologs for GAS5 Gene

Paralogs for GAS5 Gene

No data available for Paralogs for GAS5 Gene

Variants for GAS5 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for GAS5 Gene

Structural Variations from Database of Genomic Variants (DGV) for GAS5 Gene

Variant ID Type Subtype PubMed ID
esv2758978 CNV loss 17122850
nsv831926 CNV gain+loss 17160897

Additional Variant Information for GAS5 Gene

Human Gene Mutation Database (HGMD)
GAS5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GAS5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for GAS5 Gene

Disorders for GAS5 Gene

MalaCards: The human disease database

(46) MalaCards diseases for GAS5 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
malignant pleural mesothelioma
  • malignant mesothelioma of pleura
autoimmune disease
  • autoimmune hypersensitivity disease
osteoarthritis
  • kashin-beck disease
inflammatory bowel disease
  • inflammatory bowel diseases
thyroid gland papillary carcinoma
  • papillary carcinoma of the thyroid gland
- elite association - COSMIC cancer census association via MalaCards
Search GAS5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GAS5

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GAS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GAS5 Gene

Publications for GAS5 Gene

  1. A long non-coding RNA signature in glioblastoma multiforme predicts survival. (PMID: 23726844) Zhang XQ … Leung GK (Neurobiology of disease 2013) 2 3
  2. Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes. (PMID: 9819378) Smith CM … Steitz JA (Molecular and cellular biology 1998) 2 3
  3. Exosomal long non-coding RNA GAS5 suppresses Th1 differentiation and promotes Th2 differentiation via downregulating EZH2 and T-bet in allergic rhinitis. (PMID: 31841965) Zhu X … Zhao Y (Molecular immunology 2020) 3
  4. Downregulation of LncRNA GAS5 promotes liver cancer proliferation and drug resistance by decreasing PTEN expression. (PMID: 31705194) Wang C … Pan Q (Molecular genetics and genomics : MGG 2020) 3
  5. Overexpression of Growth-Arrest-Specific Transcript 5 Improved Cisplatin Sensitivity in Hepatocellular Carcinoma Through Sponging miR-222. (PMID: 32213078) Zhao P … Wang D (DNA and cell biology 2020) 3

ExternalLinks

View latest publications for GAS5 gene in Mastermind

Products for GAS5 Gene

  • Addgene plasmids for GAS5

Sources for GAS5 Gene